- Tytuł:
- EFFECTS OF VITAMIN D3 AND RESVERATROL ON MEMORY AND LEARNING IMPAIRMENT IN MICE WITH STREPTOZOTOCIN INDUCED DIABETES
- Autorzy:
- Kukula, Osman
- Powiązania:
- https://bibliotekanauki.pl/articles/895350.pdf
- Data publikacji:
- 2019-06-28
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
diabetes
memory
vitamin D3
resveratrol
learning - Opis:
- This study was conducted for investigating the effects of chronically administered vitamin D3 and resveratrol, which has antioxidant properties, on memory and learning impairment caused by streptozotocin-induced diabetes. Saline was administered to the mice in the first group. Streptozotocin (60 mg/kg, i.p.) was given to the mice in the second group for 3 consecutive days and no treatment was performed. Vitamin D3 (800 IU/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the third group for 4 weeks. Resveratrol (40 mg/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the fourth group for 4 weeks. Then, passive avoidance test was applied to the mice. A significant difference was found between DM+Vit D3 group (21.6±1.7, n=7) and diabetic control group (28±2.6, n=7) in the acquisition test (p<0.001). A similar result was observed between diabetic-resveratrol group (23.7±2.5, n=7) and the untreated diabetic mice group (28±2.6, n=7). There was a significant difference. 4-week vitamin D3 (400 IU/day, i.p.) and 4-week resveratrol (40 mg/kg, i.p.) treatments given to streptozotocin-induced diabetic mice were observed to significantly improved the passive avoidance acquisition and retention times. These results show the positive effects of vitamin D3 on memory.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 563-568
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł