- Tytuł:
- Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part IV. Equilibrium micellar solubilization of selected lipophilic therapeutic agents (BCS class II and III) in aqueous solutions of products of catalytic oxyethylation of triglyceride fractions extracted from pharmacopoeial lard (Adeps suillus PP XI) of nTE≥50
- Autorzy:
-
Marczyński, Zbigniew
Kołodziejczyk, Michał K.
Nachajski, Michał J.
Zgoda, Marian M. - Powiązania:
- https://bibliotekanauki.pl/articles/895709.pdf
- Data publikacji:
- 2019-08-30
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
valsartan
gemfibrozil
micellar solubilization
products of triglyceride fraction ethoxylation
loratadine - Opis:
- Summary: Preformulation studies were carried out to estimate the solubilization capacity of products of catalytic oxyethylation of triglyceride fractions extracted from the pharmacopoeial lard (Adeps suillus, PP XI). There were determined basic viscosity ([ɳ], Mɳ) and hydrodynamic (Ro, Robs., Ω) values of micellar solutions of oxyethylated derivatives as well as their surface activity - . Critical micellar concentration (cmc) was used to calculate the thermopotential for the formation of micelles (∆ ). Model studies on micellar solubilization of gemfibrozil, loratadine and valsartan from the solid body surface (phase boundary) were performed under equilibrium conditions at the surfactant concentration of cexp>>cmc. The amount of dissolved lipophilic therapeutic agents with qualitative and quantitative involvement of micellar solubilization was determined by spectrophotometric (UV) method - cǀsǀ (mg/100mL) as well as by calculating the solubilization indices - n|s| (mol / mol). The research study has identified structures of oxyethylated derivatives of triglyceride fractions which selectively and effectively solubilize gemfibrozil, loratadine and valsartan from the solid surface in the equilibrium system. The obtained results are a technological inspiration to create a model form of the drug (tablet) with continuous dispersion of lipophilic therapeutic agents (gemfibrozil, loratadine and valsartan), obtained on the basis of the liquefied surfactant structure. Key words: micellar solubilization, products of triglyceride fraction ethoxylation, gemfibrozil, loratadine, valsartan
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 707-714
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł