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Wyszukujesz frazę "quercetin" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    QUERCETIN ATTENUATES OXIDATIVE STRESS, INFLAMMATION AND CARDIAC DYSFUNCTION IN ACRYLAMIDE- INDUCED CARDIOTOXICITY
    Autorzy:
    Kushwah, Ajay S.
    KALIA, TARANBIR S.
    Powiązania:
    https://bibliotekanauki.pl/articles/895356.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    cardiotoxicity
    acrylamide
    quercetin
    myocardial damage
    Opis:
    Acrylamide (ACR) is a foodborne toxic agent, formed in food when processed at high temperature. This study aimed at evaluating the biochemical changes induced by ACR and the effect of Quercetin as a treatment against ACR induced cardiotoxicity in rats. Wistar rats of either sex (n=6) were divided into four groups as follows: normal control, an Acrylamide control group, Quercetin groups (25 and 50 mg/kg). Diagnostics characteristics were assessed daily, at the end of the study (4 weeks) evaluate hemodynamic parameters, the blood sample was collect for estimation of biochemical and rats were decapitated excised hearts, cleaned and weighed. Heart homogenate was used to determine antioxidants and oxidative levels, and histopathological evaluations were carried out to determine changes induced by Acrylamide. As compared control groups, ACR treated rats show altered significantly (P < 0.05) general characteristic and also elevated myocardial damage markers, altered hemodynamic, oxidative stress level, increased expression of inflammatory cytokines and induced histopathological changes. Treatment with Quercetin at 25 mg/kg and 50 mg/kg recouped the above changes significantly (P < 0.05), 50 mg/kg being more prominent. The present study has concluded that Quercetin protects against Acrylamide-induced cardiotoxicity.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 343-352
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    VALIDATION OF HEPATOPROTECTIVE USE OF POLYGONUM PERFOLIATUM EXTRACT AGAINST PARACETAMOL INDUCED TOXICITY IN WISTAR RATS
    Autorzy:
    Saleem, Mohammad
    Mushtaq, Muhammad Fahd
    Akhtar, Muhammad Furqan
    Saleem, Ammara
    Zahid, Sara
    Sharif, Ali
    Akhtar, Bushra
    Dar, Eshwa
    Ullah, Majeed
    Badshah, Munair
    Powiązania:
    https://bibliotekanauki.pl/articles/895499.pdf
    Data publikacji:
    2019-04-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    HPLC
    paracetamol
    hepatotoxicity
    vitamin E
    quercetin
    hepatoprotective
    Opis:
    The liver as a vital body organ is adversely affected by hazardous chemicals and drugs. Paracetamol widely used as analgesic and antipyretic drug produces severe hepatotoxicity at high doses. Present study was designed to investigate the hepatoprotective activity of Polygonum perfoliatum L. used on folklore basis. Aqueous methanolic extract of the plant was prepared. Preliminary phytochemical and HPLC analyses were carried out to identify and quantify chemical constituents respectively. For hepatoprotective activity, Wistar rats were divided into six groups as normal control, standard (silymarin) control, negative control and extract treated groups i.e., 125, 250 and 500 mg/kg/day per oral. Paracetamol was administered orally, following seven days of previously stated therapy. Biochemical parameters of hepatotoxicity such as serum glutamic pyruvate transaminase (SGPT), serum glutamic oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and total bilirubin were measured in all groups. Histopathological evaluation of liver was also carried out. Benzoic acid, chlorogenic acid, gallic acid, m-coumaric acid, quercetin and vitamin E were detected in the plant extract through HPLC. The hepatoprotective effect of 500 mg/kg/day therapy was more pronounced than 125 and 250 mg/kg dose. However, the effect of plant extract was less pronounced than standard silymarin therapy. It can be concluded that the plant extract possessed significant hepatoprotective activity that may be attributed to quercetin, benzoic acid, gallic acid and vitamin E present in it.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 283-289
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Quercetin influences BSA alpha-helical structures of native, ACR- and NaNO2-modified BSAs
    Autorzy:
    Rorbach-Dolata, Anna
    Żurawska-Płaksej, Ewa
    Piwowar, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/895290.pdf
    Data publikacji:
    2018-12-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    albumin
    quercetin
    nitrosylation
    alkylation
    conformational changes
    circular dichroism
    Opis:
    Quercetin (QUE) is a plant flavonoid with a multifarious spectrum of properties. It is a prominent component of the human diet, considered to be safe and beneficial for human health. Acrylamide (ACR) and sodium nitrate III (NaNO2) are also present in the diet and may demonstrate adverse and toxic effects on the macromolecules and tissues of the human organism. Albumin, the most abundant blood protein, is the most susceptible to the action of various exogenous factors, which may lead to structural damage and functional disturbances. The aim of this study was to estimate ACR- and NaNO2-induced changes in the secondary structure of bovine serum albumin (BSA), using circular dichroism (CD), and to determine the impact of quercetin on these modifications. BSA was incubated with ACR and NaNO2 solutions in the absence and presence of QUE in two different concentrations (3 mM and 500 µM), and changes in albumin alpha-helical structure were determined by CD. BSA secondary structure was vulnerable to alterations upon treatment with acrylamide and NaNO2, as well as quercetin. QUE, depending on concentration and incubation time, caused a decrease of around 13-19% in the alpha-helix content of BSA molecules, but also prevented the changes in the protein alpha-helical structure initiated by ACR and NaNO2. The most spectacular inhibition was revealed for QUE in lower concentrations after 24h of incubation with NaNO2. Although QUE reveals protective effect towards albumin modifications, it is difficult to unambiguously define whether this effect is advantageous, because quercetin itself causes alterations in BSA structure.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1339-1346
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    QUERCETIN AMELIORATES INSULIN RESISTANCE CONCOMITANT EARLY CARDIOVASCULAR CHANGES IN EXPERIMENTAL RATS
    Autorzy:
    KUSHWAH, AJAY S.
    GUPTA, GHANSHYAM D.
    Powiązania:
    https://bibliotekanauki.pl/articles/895413.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    insulin resistance
    oxidative stress
    myocardium
    quercetin
    high-fructose diet
    5' Adenosine Monophosphate-activated Protein Kinase
    Opis:
    Quercetin is a dietary flavonoid found in a wide range of fruits and vegetables; it has diverse biological activities, possesses beneficial effects in ameliorating diabetic complications, apart from the effect of quercetin on fructose feed induced insulin resistance (IR) linked cardiac dysfunction have not been entirely revealed. This study aspires to explore the effect of quercetin on metabolism, oxidative stress, cardiomyocytes damage and cardiac function in IR state. Wistar rats either sex weighing 220-250 g (n ꞊8), were divided into four groups, kept on either control diet and high fructose diet and supplement with a quercetin as a test drug and metformin as a standard, at the dose of 50 and 200 mg/ kg; p.o., respectively. Daily measured body weight, feed, and water intake for 35 days, Oral glucose tolerance test (OGTT) performed in animals on the 32nd day. At end of the study (36th day), measured hemodynamic parameters after that estimation of various biochemical parameters. Finally, the animals were sacrificed for isolation of tissues and measured heart weight, the oxidative stress level of heart and histopathological changes. Treatment of quercetin with fructose-fed ameliorated all the parameters revile by the contrast of IR rats. The outcome of quercetin associated improves insulin sensitivity, normalized lipid profile, abolish hemodynamic changes, oxidative stress and cardiac injury markers within fructose-fed, and lesser histopathological changes were observed contrast with IR rats. These beneficial effects of quercetin mediated by improving insulin sensitivity and metabolism; reduced oxidative stress could potentially be used to ameliorate the myocardial damage.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 977-987
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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