- Tytuł:
- Development of tablets containing solid dispersion of ibuprofen manufactured by Hot Melt Impregnation process.
- Autorzy:
-
Garbera, Kamil
Woś-Latosi, Katarzyna
Sawicki, Wiesław - Powiązania:
- https://bibliotekanauki.pl/articles/895495.pdf
- Data publikacji:
- 2019-04-30
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
Ibuprofen
solid dispersion
hot melt extrusion
hot melt impregnation
amorphisation
solubility enhancement - Opis:
- The main assumption of given study was to develop tablets containing amorphous ibuprofen by hot melt extrusion process. However proposed manufacturing procedure demonstrates quite a few differences in comparison to a conventional hot melt extrusion. Accurately the given manufacturing procedure has been called a hot melt impregnation due to the process characteristics. As a product of described process a fine free flowing extrudate is obtained. Four different compositions have been proposed. Materials prepared by hot melt impregnation technique have been extensively examined in terms of physicochemical properties and then were subjected to tablet compression process. Obtained tablets were examined in terms of thermodynamic stability and compared to marketed product containing ibuprofen.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 341-354
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł