- Tytuł:
- Novel Aryl/Alkyl Azole Derivates as an anti-nociceptive and anti-inflammatory drug candidates
- Autorzy:
-
Kaya-Yasar, Yesim
Barut, Elif N.
Engin, Seckin
Dogan, Inci S.
Sezen, Feride S. - Powiązania:
- https://bibliotekanauki.pl/articles/895330.pdf
- Data publikacji:
- 2020-04-29
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
pain
inflammation
aryl/alkyl azole
COX-LOX
formalin-induced hind paw edema test
hot plate test - Opis:
- Novel aryl/alkyl azole derivative compounds C1 and C2 were screened for in vivo anti-nociceptive and anti-inflammatory activities by using the hot plate test and formalin-induced hind paw edema test, respectively. Ability of these compounds to inhibit cyclooxygenase-1/2 (COX-1/2) and 5/15-lipoxygenase (5/15-LOX) were evaluated in vitro by using a colorimetric method. C1 (30 and 50 mg/kg, i.p.) and C2 (3 and 30 mg/kg, i.p.) increased the latency to withdrawal in the hot plate test, indicating an anti-nociceptive activity. C1(30 and 50 mg/kg) and C2 (3,30 and 50 mg) were able to decrease formalin-induced edema, indicating their anti-inflammatory properties. C1 and C2 exhibited inhibitory effects on the activity of COX(1-2) and 15-LOX. However, neither C1 nor C2 showed an inhibitory effect on 5-LOX. This study demonstrates that C1 and C2 have anti-nociceptive and anti-inflammatory activities, that is partially mediated by inhibition of COX and LOX enzymes. Our results suggest that C1 and C2, novel aryl/alkyl azole compounds, could serve as lead compounds to develop novel therapeutic options for the treatment of pain and inflammation.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 289-294
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł