Autor: Wietrzyk, Joanna - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: DESIGN, SYNTHESIS AND ANALYSIS OF ANTICANCER ACTIVITY OF NEW SAR-BASED S16020 DERIVATIVES
Autorzy:: Tylińska, Beata
Jasztold-Howorko, Ryszard
Kowalczewska, Karina
Szczaurska-Nowak, Katarzyna
Gębarowski, Tomasz
Wietrzyk, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/895419.pdf
Data publikacji:: 2018-12-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: A549
cytostatic
olivacine
S16020
NHDF
A498
Opis:: A novel set of S16020 derivatives was designed applying structure activity relationships (SAR). The newly synthesized compounds were subjected to in vitro cytostatic activity screening against human kidney cancer (cell line A498), human lung cancer (cell line A549) and normal human dermal fibroblasts (cell line NHDF). Two 6H-pyrido[4,3-b]carbazole derivatives exhibited stronger potency against both investigated cell lines than the reference compounds ellipticine and doxorubicin.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1313-1320
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Design, Efficient Synthesis, Mechanism of Reaction and Antiproliferative Activity Against Cancer And Normal Cell Lines of A Novel Class of Fused Pyrimidine Derivatives
Autorzy:: roaiah, hanaa F.
Rashdan, Huda R.
soliman, abdelmohsen
Muhammed, Zeinab
Wietrzyk, Joanna
Milczarek, Magdalena
Powiązania:: https://bibliotekanauki.pl/articles/895705.pdf
Data publikacji:: 2018-06-30
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: anticancer activity
antiproliferative activity
Coumarin
Fused pyrimidines
3-triazole
Opis:: This work concentrated on the utility of hydrazonoyl halides in synthesis of bioactive heterocycles like triazoles, pyrazoles, pyrimidines and their fused derivatives which have a wide spectrum of pharmaceutical value. Herein we discussed the synthesis of new heterocyclic compounds containing fused pyrimidine rings derived from hydrazonoyl halides and their significant pharmaceutical importance as anticancer agents. New fused pyrimidine derivatives bearing 1,2,3-triazole moiety were prepared via reaction of enaminone 2 with and 6-amino-2-thioxo-pyrimidin-4-one and then with hydrazonoyl chlorides 6a-h. In addition 3-amino-6-(2-oxo-2H-chromen-3-yl)pyridine-2-carbonitrile (12) was submitted to react with carbon dioxide to afford 3-(1,2,3,4-tetrahydro-2,4-dithioxopyrido[2,3-d]pyrimidin-7-yl)-2H-chromen-2-one (15), which act as key molecule for synthesis of new series of fused prymidinethione derivatives containing coumarine moiety via its reaction with different selected derivatives of hydrazonoyl halides 6a-h. Structures of the newly synthesized compounds were confirmed using spectral data (IR, H1NMR and Mass spectrometry) and microanalytical methods. Also, they screened for their anticancer activity.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "Wietrzyk, Joanna" wg kryterium: Autor

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język