- Tytuł:
- Phyllodulcin Protects PC12 Cells Against the Injury Induced by Oxygen and Glucose Deprivation-Restoration
- Autorzy:
-
Hu, Chang-Long
Ge, Lu
Tang, Yong
Li, Jie
Wu, Chun-Hui
Hu, Jiang-Hong
Yuan, Jin-Tao
Fan, Yong-Zhong - Powiązania:
- https://bibliotekanauki.pl/articles/895391.pdf
- Data publikacji:
- 2019-12-29
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
apoptosis
oxidative stress
PC12 cells
phyllodulcin
oxygen and glucose deprivation/restoration - Opis:
- Phyllodulcin is a natural coumarin derivative found in Hydrangea macrophylla. To discover effective therapeutics for cerebral ischemia-reperfusion injury, we investigated the protective effects of phyllodulcin on PC12 cells injury induced by oxygenation and glucose deprivation/restoration (OGD/R). As a result, phyllodulcin can improve the cell viability and attenuate the extracellular lactate dehydrogenase release. Meanwhile, phyllodulcin can ameliorate the dysfunction of mitochondria through reducing reactive oxygen species production, decreasing the intracellular calcium level and increasing the mitochondrial membrane potential. ROS-associated OGD/R can induce cell apoptosis through the mitochondrial pathway. Phyllodulcin can inhibit apoptosis of PC12 cells through down-regulation of Caspase-3 and Bax as well as up-regulation of Bcl-2. These results indicate phyllodulcin can protect PC12 cells against the damage induced by OGD/R. This investigation gives promising evidences for the therapy of cerebral ischemia-reperfusion injury.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1043-1050
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł