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    Tytuł:
    Effect of Solublising Aids on The Entrapment of Loratidine in Pre-Fabricated PVA Filaments Used for FDM Based 3D-Printing
    Autorzy:
    Mahmood, Faisal
    Hussain, Amjad
    Arshad, Muhammad Sohail
    Abbas, Nasir
    Irfan, Muhammad
    Qamar, Nadia
    Hussain, Fahad
    Ghori, Muhammad Usman
    Powiązania:
    https://bibliotekanauki.pl/articles/895332.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    3D printing
    Plasticizers
    Fused deposition modelling (FDM)
    PVA filaments
    Solubilizers
    Opis:
    Low drug loading efficiency is the limiting factor in the use of pre-fabricated filaments for 3D printing of pharmaceuticals. The aim of present study was to modify the material properties of pre-fabricated filament by incorporating the suitable solubilizing aids in order to enhance the drug loading efficiency. Loratadine was loaded into PVA filaments by using solubilizers (Soluplus®, Sodium lauryl sulphate) and plasticizers (glycerin and Polyethylene glycol-400) and the printability of filaments was investigated. The treated filaments were characterized for morphology and diameter changes, drug content, FTIR and thermal properties and printed into tablets of suitable dimensions. The printed tablets were also characterized for drug assay and drug release. The results have shown that the surface of different drug loaded filaments become rough with almost no change in diameter hence, these filaments remained printable. However, there was 7 to 24 times enhancement in drug content of filaments treated with particularly those pretreated with glycerin and soaked in drug solution containing Soluplus. The printed tablets have also shown almost similar drug content as their precursor filaments and the release followed diffusion mechanism in most of the formulations. The study concludes that the treatment of PVA filament with solubilizer aids has significantly improved the drug loading entrapment without compromising the printability.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 175-182
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FORMULATION AND EVALUATION OF INDOMETHACIN LOADED NANOSPONGES FOR ORAL DELIVERY
    Autorzy:
    Abbas, Nasir
    Sarwar, Komal
    Irfan, Muhammad
    Hussain, Amjad
    Mehmood, Rabia
    Arshad, Muhammad S.
    Shah, Pervaiz A.
    Powiązania:
    https://bibliotekanauki.pl/articles/895238.pdf
    Data publikacji:
    2018-10-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    sustained release
    indomethacin
    Nanosponges
    Emulsion solvent diffusion method
    Franz diffusion cell
    Opis:
    Nanosponges (NS) loaded sustained release tablet formulations of a non-steroidal anti-inflammatory drug; Indomethacin were successfully developed and evaluated for their pharmaceutical properties. Twelve nanosponge formulations were fabricated by solvent diffusion method by using different ratios of drug and polymers (ethyl cellulose and polyvinyl alcohol). Particle size of all the formulations was in the nano range of 221 to 625 nm and it was found dependent on the polymer concentration. Drug loading and entrapment efficiency was ranged in 32.2 to 59.4 % and 30.1 to 64.8 %, respectively. Formulations with equal proportion of drug and polymer resulted in higher values of drug loading and entrapment efficiency. Percent yield was also found dependent on the relative drug polymer ratio with highest value of 51 % was achieved for the formulation having same drug to polymer ratio. SEM results confirmed the formation of spherical and porous structures. Structural analysis by Fourier transform infrared spectroscopy (FTIR), powder x-ray diffraction (PXRD) showed the absence of any interaction between drug and polymer. In comparison to pure drug, NS formulations showed a linear intrinsic dissolution rate (IDR) profile depicting a controlled release profile. Diffusion studies of NS formulations performed by Franz diffusion cell and dialysis bag methods showed comparable results in terms of precision and linearity of diffusion profile. Tablets prepared from the drug loaded NS showed acceptable values for hardness, friability and drug content. Release of drug from NS tablets was confirmed as sustained release behaviour.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1201-1213
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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