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    Wyświetlanie 1-7 z 7
    Tytuł:
    Heavy Ion Beams for Radiobiology: Dosimetry and Nanodosimetry at HIL
    Autorzy:
    Kaźmierczak, U.
    Bantsar, A.
    Banaś, D.
    Braziewicz, J.
    Czub, J.
    Jaskóła, M.
    Korman, A.
    Kruszewski, M.
    Lankoff, A.
    Lisowska, H.
    Pietrzak, M.
    Pszona, S.
    Stępkowski, T.
    Szefliński, Z.
    Wojewódzka, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1402627.pdf
    Data publikacji:
    2015-05
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.53.Bn
    87.53.-j
    Opis:
    Ionizing radiation induces a variety of DNA lesions, including single and double strand breaks. Large energy deposition precisely localized along the ion track that occurs in the case of heavy ion irradiation can lead to complex types of DNA double strand breaks in exposed biological material. The formation of nuclear double strand breaks triggers phosphorylation of histone H2AX, which can be microscopically visualized as foci in the γ-H2AX assay. Studies with a carbon ion beam are being carried out at the Heavy Ion Laboratory of the University of Warsaw. The γ-H2AX assay as a method of measuring the biological response of cells irradiated with $\text{}^{12}C$ ions as well as the frequency cluster size distributions obtained in the nanodosimetry experiment at HIL will be presented.
    Źródło:
    Acta Physica Polonica A; 2015, 127, 5; 1516-1519
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of 60 MeV Protons and 250 kV X-Rays on Cell Viability
    Autorzy:
    Miszczyk, J.
    Panek, A.
    Rawojć, K.
    Swakoń, J.
    Prasanna, P.
    Rydygier, M.
    Gałaś, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1398817.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    87.53.-j
    87.53.Bn
    Opis:
    Particle radiotherapy such as the one using proton beams, provides a successful treatment approach in many cancer types. However, the cellular and molecular mechanisms by which proton irradiation induces cell death, particularly in a human peripheral blood lymphocyte model has not been examined in detail. Comparative studies of the biological effects, such as cell death, of particle therapy versus conventional X-rays treatment are of utmost importance. Here, we compared the viability of human peripheral blood lymphocyte following in vitro irradiation with protons (therapeutic 60 MeV proton beam) and photon beam (250 kV, X-rays), by applying separate doses within the range of 0.3-4.0 Gy. Cell viability was assessed 1 and 4 h after irradiation with protons and X-rays by the FITC-Annexin V labelling procedure (Apoptotic & Necrotic & Healthy Cells Quantification Kit, Biotium). Results showed that irradiation with both radiation types reduced the number of viable cells in a dose-dependent manner, as assessed as a function of the duration of post-irradiation time. Protons proved more fatal to the cells treated than X-ray photons. This demonstrates a difference in cell viability after irradiation with protons and photons in a human peripheral blood lymphocyte model.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 222-225
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research
    Autorzy:
    Panek, A.
    Błażewicz, M.
    Frączek-Szczypta, A.
    Adamczyk, J.
    Wiltowska-Zuber, J.
    Paluszkiewicz, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/1030633.pdf
    Data publikacji:
    2018-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.53.-j
    87.85.jj
    87.14.gk
    Opis:
    The single cell gel electrophoresis method, known as comet assay, is a rapid and sensitive technique for testing novel chemicals and nanoparticles for genotoxicity, monitoring environmental contamination with genotoxins and human biomonitoring. In our studies we check the applicability of this method for the evaluation of biocompatibility of modified (MWNF) and non-modified multi-walled carbon nanotubes (MWNT) as well as potential genotoxicity of mercury(II) nitrate. The obtained results enabled us to conclude that the presence of Hg(NO₃)₂ (p<0.001) and MWNT (p<0.04) cause a significantly higher level of DNA damage in comparison to functionalised nanomaterials MWNF. It was implied that for the three investigated agents only mercury significantly enhanced genotoxic effect of X-ray exposure (p<0.001) and inhibition of radio-induced DNA damage repair. On the contrary, the presence of MWNF have no influence on cellular repair efficiencies, while incubation with MWNT causes apoptosis and consequently results in lack of attached cells. In conclusion, our results confirmed the genotoxicity of mercury and non-modified carbon nanotubes as well as the biocompatibility of modified nanotubes. Additionally, we proved the usefulness of comet method for the evaluation of genotoxicity and DNA repair under the influence of different compounds and nanomaterials.
    Źródło:
    Acta Physica Polonica A; 2018, 133, 2; 280-282
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    European ENVISION Project for Improving Timing Resolution in PET Systems
    Autorzy:
    Oliver, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1402626.pdf
    Data publikacji:
    2015-05
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.57.nf
    87.53.-j
    87.56.Fc
    Opis:
    Hadrontherapy uses charged particles to destroy tumors. For improving the quality assurance tools, specially range verification, the European Commission funded the project ENVISION. This paper summarizes the activities carried out within the work package two devoted to improve the visualization of the spatial distribution of positron emitters that are produced during patient irradiation. Allowing the beam passage implies a reduction in the angular coverage which degrades the range assessment. The aim of the work package two was to investigate the potential use of time-of-flight information for compensating this degradation. The studies can be classified into hardware and software developments. For the former, several ASICs and DAQs have been investigated. Also, the potential application of resistive plate chambers has been assessed. Four dual-head demonstrators have been produced by the end of the project. The software developments are divided into simulations and image reconstruction. Several algorithms able to include the time-of-flight information have been developed. Direct reconstruction has been implemented and compared with conventional maximum-likelihood methods. The results show that direct time-of-flight for on-line reconstruction is possible although iterative algorithms can achieve further improvements. However, time-of-flight alone might not be sufficient due to the low emission rates.
    Źródło:
    Acta Physica Polonica A; 2015, 127, 5; 1513-1515
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of External Radiation Dose Changes in Some X-ray Applications
    Autorzy:
    Coşkun, A.
    Mavi, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/1402421.pdf
    Data publikacji:
    2015-08
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.57.Q-
    87.55.N-
    87.53.-j
    Opis:
    Ionizing radiation is commonly used in diagnostic and therapeutic applications in medicine. Therefore, both staff and patients are exposed to the biological influence of radiation. Biological effects and damages are proportional to the irradiation.In this study the radiation dose to human in the patient room and the technician room at computed tomography and X-ray units were measured and compared for different situations.
    Źródło:
    Acta Physica Polonica A; 2015, 128, 2B; B-365-B-366
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    At the Tip of an MeV Beam: Provoking Cells and Performing Tomographic Imaging
    Autorzy:
    Pallon, J.
    Arteaga-Marrero, N.
    Nilsson, Ch.
    Elfman, M.
    Kristiansson, P.
    Nilsson, C.
    Wegdén, M.
    Olsson, M.
    Åkerström, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/1808531.pdf
    Data publikacji:
    2009-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    07.79.-v
    29.40.Wk
    87.53.-j
    87.53.Ay
    25.40.Cm
    29.30.Ep
    29.30.Kv
    61.43.Gt
    Opis:
    Biological applications of ion beams have recently become a new important research field using single ion hit facilities to study individual living cells and their response to the hit of a counted number of ions. One motivation is the search for a better understanding of the fundamental processes taking place in cells and organs as a result of irradiation. Another comes from the increasing interest in using high energy protons and heavy ions as a modality for radiotherapy of deep seated tumours. In the view of treatment efficiency, study of cell culture behaviour under controlled radiation experiments, and in different chemical environments at single ion hit facilities, is a first step towards a better understanding of the processes. Tomographic techniques are applicable to situations where you need information of the inside of an object but do not want to section it into thin slices or cannot do it. Using focused MeV ion beams for tomography restricts the sample size to the order of 10-100 μm, depending of the initial energy. On the other hand, the ability to focus at a sub-micrometer level makes ion beams well suited for analyses of small sized objects as cells, spores, etc. The scanning transmission ion microscopy mode of tomography gives the mass density and corresponding morphological structure of holes and pores. It can then be used to correct the results from the other mode, particle induced X-ray emission tomography. Here is discussed a porosity analysis of bentonite clay that is planned to form an important buffer zone around canisters filled with spent nuclear reactor fuel waste deposited 500 m underground in Sweden.
    Źródło:
    Acta Physica Polonica A; 2009, 115, 2; 501-506
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of magnetite composite on the amount of double strand breaks induced with X-rays
    Autorzy:
    Wiecheć, A.
    Nowicka, K.
    Błażewicz, M.
    Kwiatek, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1065182.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    87.53.-j
    81.05.Mh
    81.05.Ni
    81.05.Pj
    81.05.Qk
    75.50.Bb
    Opis:
    The aim of this study was to find out if polylactide (PLA) modified with magnetite might affect the amount of DNA double strand breaks induced with X-rays. The human osteosarcoma cells (MG63) were seeded on the polystyrene cell culture dishes (PS), PLA and PLA modified with magnetite substrates. The double strand breaks were analyzed after X-ray irradiation (dose rate 2 Gy/min), in the first day of culturing. The number of double strand breaks increased in the PLA modified with magnetite, for example after 1 Gy of X-rays irradiation, double strand breaks/cell equaled: 24.5 vs. 17.5 and 17.3, for PLA modified with magnetite vs. PLA and PS, p < 0.0003. We conclude that PLA modified with magnetite changed the number of double strand breaks induced with X-rays. However, more research is needed to confirm that such composite might be considered as radiosensitizer in radiotherapy.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 174-175
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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