Autor: Dobrota, D. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Comparison of Iron Oxide-Related MRI Artifacts in Healthy and Neuropathological Human Brain Tissue
Autorzy:: Masarova, M.
Krafcik, A.
Teplan, M.
Strbak, O.
Gogola, D.
Boruta, P.
Dobrota, D.
Frollo, I.
Powiązania:: https://bibliotekanauki.pl/articles/1032293.pdf
Data publikacji:: 2017-04
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 87.61.Ff
75.50.Cc
87.19.xr
87.19.xe
Opis:: The aim of this study is to clarify whether clinical magnetic resonance imaging data can be utilised to evaluate the pathological processes associated with disrupted iron homeostasis, such as neurodegenerative processes or cirrhosis. Although MRI has the potential to become a non-invasive biomarker of such pathology, new quantification methods must be introduced. Our findings confirmed that it is possible to detect significant difference between healthy and pathological tissue from standard T2 weighted MRI protocols.
Źródło:: Acta Physica Polonica A; 2017, 131, 4; 1108-1110
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Differentiation of Native and Reconstructed Ferritin using the MRI Gradient Echo Pulse Sequence
Autorzy:: Balejcikova, L.
Strbak, O.
Baciak, L.
Kovac, J.
Masarova, M.
Krafcik, A.
Kopcansky, P.
Dobrota, D.
Frollo, I.
Powiązania:: https://bibliotekanauki.pl/articles/1032829.pdf
Data publikacji:: 2017-04
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 75.60.Ej
83.85.Fg
87.61.-c
87.64.Cc
87.85.jf
Opis:: Ferritin is a biological iron storage biomacromolecule, consisting of a spherical protein shell (apoferritin) and mineral iron core. It plays a crucial role in the pathological processes of disrupted iron homeostasis followed by iron accumulation, linked with various disorders (e.g. neuroinflammation, neurodegeneration, cirrhosis, cancer, etc.) In vitro reconstructed ferritin, with the assistance of a non-invasive magnetic resonance imaging technique, has the potential to become a suitable biomarker of these pathological processes. Through gradient echo pulse sequencing, we were able to clearly distinguish between native (physiological) and reconstructed/iron-overloaded (pathological) ferritin, which can serve as a starting point for the development of a method for their differentiation. Such method is necessary for the early diagnosis of iron-based diseases.
Źródło:: Acta Physica Polonica A; 2017, 131, 4; 1093-1095
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 3.

Tytuł:: Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI
Autorzy:: Strbak, O.
Kubovcikova, M.
Baciak, L.
Khmara, I.
Gogola, D.
Koneracka, M.
Zavisova, V.
Antal, I.
Masarova, M.
Krafcik, A.
Kopcansky, P.
Dobrota, D.
Frollo, I.
Powiązania:: https://bibliotekanauki.pl/articles/1032224.pdf
Data publikacji:: 2017-04
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 87.61.-c
75.75.Fk
87.15.kp
Opis:: The aim of the study was to establish whether there is a significant change in the MRI contrast of magnetite nanoparticles, after BSA protein binding on the surface of particles. The rationale is the applicability of this feature in clinical practice for the tracking of specific proteins which are often associated with various pathologies. Contrast agents could bind to this specific marker, with the change in MRI contrast indicating the presence of pathology. We found that changes in relative contrast acquired at low-field MRI offer potential for the differentiation of magnetite nanoparticles with and without BSA protein. However, the variations in the transverse relaxation time (T₂) and transverse relaxivity (r₂), acquired at high-field MRI, were too small to be applicable for biomedical applications.
Źródło:: Acta Physica Polonica A; 2017, 131, 4; 1102-1104
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

Artykuł

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