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Wyszukujesz frazę "cystatin C" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Cystain C and neuropeptid Y levels in brain tissues after experimental subarachnoid hemorrhage
    Autorzy:
    Açıkgöz, Şerefden
    Can, Murat
    Güven, Berrak
    Edebali, Nurullah
    Barut, Figen
    Büyükuysal, Çağatay
    Tekin, İshak
    Açıkgöz, Bektaş
    Powiązania:
    https://bibliotekanauki.pl/articles/1039224.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cystatin C
    neuropeptid Y
    experimental subarachnoid hemorrhage
    Opis:
    The aim of this study was to investigate the changes in the levels of cystatin C, which protects neurodegeneration in the central nervous system with the inhibition of cysteine protease and by inducing autophagy in the pathogenesis of cerebral vasospasm and levels of vasoconstrictive neuropeptid Y (NPY) in the brain tissue homogenates of rat model of subarachnoid hemorrhage (SAH). Three experimental groups were used: Day 2 and Day 7 groups after SAH, and also a control group. There were seven Wistar albino rats in each group. SAH was accomplished by transclival basilar artery puncture. Rat cystatin C, rat NPY were determined with ELISA in brain tissue homogenates. Day 2 group showed significantly enhanced cystatin C values in comparision with the control group (P=0.048). NPY levels between the Day 2 and Day 7 groups and the control groups were not significantly different (P=0.315). In histopathological examination, there was less neuronal loss in the Day 2 group than in the Day 7 group. Regarding our results, it would be more valuable to measure NPY levels in specific brain areas. The increased cystatin C levels on the second day after SAH is probably a pathophysiologic mechanism to organize protease activity.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 4; 825-828
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of antisense peptide binding on the dimerization of human cystatin C - gel electrophoresis and molecular modeling studies.
    Autorzy:
    Stachowiak, Krystyna
    Rodziewicz-Motowidło, Sylwia
    Sosnowska, Renata
    Kasprzykowski, Franciszek
    Łankiewicz, Leszek
    Grubb, Anders
    Grzonka, Zbigniew
    Powiązania:
    https://bibliotekanauki.pl/articles/1043334.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    dimerization
    antisense peptides
    human cystatin C
    molecular dynamics
    Opis:
    Human cystatin C (HCC) shows a tendency to dimerize. This process is particularly easy in the case of the L68Q HCC mutant and might lead to formation of amyloid deposits in brain arteries of young adults. Our purpose was to find ligands of monomeric HCC that can prevent its dimerization. Eleven antisense peptide ligands of monomeric HCC were designed and synthesized. The influence of these ligands on HCC dimerization was studied using gel electrophoresis and molecular modeling methods. The results suggest that all the designed peptides interact with monomeric HCC facilitating its dimerization rather than preventing it.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 1; 153-160
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determinants of plasma homocysteine in coal miners
    Autorzy:
    Mungan, A
    Can, Murat
    Kıran, Sibel
    Açıkgöz, Şerefden
    Güven, Berrak
    Powiązania:
    https://bibliotekanauki.pl/articles/1039548.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    coal miners
    homocysteine
    cystatin C
    vitamin B12
    folate
    Opis:
    Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 443-449
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Governing the monomer-dimer ratio of human cystatin c by single amino acid substitution in the hinge region
    Autorzy:
    Szymańska, Aneta
    Radulska, Adrianna
    Czaplewska, Paulina
    Grubb, Anders
    Grzonka, Zbigniew
    Rodziewicz-Motowidło, Sylwia
    Powiązania:
    https://bibliotekanauki.pl/articles/1040538.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    dimerization
    point mutation
    hinge loop
    human cystatin C
    conformational tension
    Opis:
    Three dimensional domain swapping is one of the mechanisms involved in formation of insoluble aggregates of some amyloidogenic proteins. It has been proposed that proteins able to swap domains may share some common structural elements like conformationally constrained flexible turns/loops. We studied the role of loop L1 in the dimerization of human cystatin C using mutational analysis. Introduction of turn-favoring residues such as Asp or Asn into the loop sequence (in position 57) leads to a significant reduction of the dimer fraction in comparison with the wild type protein. On the other hand, introduction of a proline residue in position 57 leads to efficient dimer formation. Our results confirm the important role of the loop L1 in the dimerization process of human cystatin C and show that this process can be to some extent governed by single amino acid substitution.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 3; 455-463
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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