Temat: Rho - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements
Autorzy:: Szczepanowska, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/1040556.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: PAK substrates
PAK kinase
Rho GTPases
cytoskeletal organization
Opis:: The p21-activated kinases (PAKs) are serine/threonine protein kinases interacting with small GTPases - Rac and Cdc42. PAKs are found in most eukaryotes and play an evolutionarily conserved role in many cellular processes. Six human PAKs have been identified, and based on homology, they can be classified into two groups. This review focuses specifically on the role of Rac/Cdc42 regulated PAKs in maintaining and remodeling cytoskeletal structure in various organisms. A list of PAKs substrates and binding partners implicated directly and indirectly in cytoskeletal reorganization is presented. Also perturbations of the Rac/Cdc42/PAK pathway leading to tumorigenesis and neurodegenerative diseases are reviewed.
Źródło:: Acta Biochimica Polonica; 2009, 56, 2; 225-234
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Translational frameshift sites within bacteriophage λ genes rexA and cI
Autorzy:: Hayes, Sidney
Bull, Harold
Powiązania:: https://bibliotekanauki.pl/articles/1044444.pdf
Data publikacji:: 1999
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Rex exclusion
rho-dependent transcriptional terminator
CI repressor
bacteriophage l
translational frameshift
Opis:: Phage λ's cI-rexA-rexB operon displays an intriguing example of regulation by an unexplained mechanism of polarity. We have identified three potential -1 translational frameshift sites and present a model for translational frameshift suppression by lambda's CI repressor as a mechanism of regulating operon polarity, implying an additional role for CI self-regulation.
Źródło:: Acta Biochimica Polonica; 1999, 46, 4; 879-884
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Structure of small G proteins and their regulators.
Autorzy:: Paduch, Marcin
Jeleń, Filip
Otlewski, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/1043851.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: small G protein
GAP
protein-protein interaction
GTPase
GDI
Rho
Ras
protein tertiary structure
GEF
Opis:: In recent years small G proteins have become an intensively studied group of regulatory GTP hydrolases involved in cell signaling. More than 100 small G proteins have been identified in eucaryotes from protozoan to human. The small G protein superfamily includes Ras, Rho Rab, Rac, Sar1/Arf and Ran homologs, which take part in numerous and diverse cellular processes, such as gene expression, cytoskeleton reorganization, microtubule organization, and vesicular and nuclear transport. These proteins share a common structural core, described as the G domain, and significant sequence similarity. In this paper we review the available data on G domain structure, together with a detailed analysis of the mechanism of action. We also present small G protein regulators: GTPase activating proteins that bind to a catalytic G domain and increase its low intrinsic hydrolase activity, GTPase dissociation inhibitors that stabilize the GDP-bound, inactive state of G proteins, and guanine nucleotide exchange factors that accelerate nucleotide exchange in response to cellular signals. Additionally, in this paper we describe some aspects of small G protein interactions with downstream effectors.
Źródło:: Acta Biochimica Polonica; 2001, 48, 4; 829-850
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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