Temat: MMA - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation
Autorzy:: Bialik-Wąs, Katarzyna
Pielichowski, Krzysztof
Powiązania:: https://bibliotekanauki.pl/articles/1039502.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: metronidazole
poly(AA-co-MMA)
drug delivery systems
Opis:: We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and 1H NMR, as well as surface morphology assessment by SEM, were performed.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 835-838
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Tocopherol esters inhibit human glutathione S-transferase omega
Autorzy:: Sampayo-Reyes, Adriana
Zakharyan, Robert
Powiązania:: https://bibliotekanauki.pl/articles/1041213.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: glutathione S-transferase
human
hGSTO1-1
MMA(V) reductase
Vitamin E
Opis:: Human glutathione S-transferase omega 1-1 (hGSTO1-1) is a newly identified member of the glutathione S-transferase (GST) family of genes, which also contains alpha, mu, pi, sigma, theta, and zeta members. hGSTO1-1 catalyzes the reduction of arsenate, monomethylarsenate (MMA(V)), and dimethylarsenate (DMA(V)) and exhibits thioltransferase and dehydroascorbate reductase activities. Recent evidence has show that cytokine release inhibitory drugs, which specifically inhibit interleukin-1b (IL-1b), directly target hGSTO1-1. We found that (+)-α-tocopherol phosphate and (+)-α-tocopherol succinate inhibit hGSTO1-1 in a concentration-dependent manner with IC50 values of 2 µM and 4 µM, respectively. A Lineweaver-Burk plot demonstrated the uncompetitive nature of this inhibition. The molecular mechanism behind the inhibition of hGSTO1-1 by α-tocopherol esters (vitamin E) is important for understanding neurodegenerative diseases, which are also influenced by vitamin E.
Źródło:: Acta Biochimica Polonica; 2006, 53, 3; 547-552
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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