- Tytuł:
- Synaptic protein UNC-13 interacts with an F-box protein that may target it for degradation by proteasomes
- Autorzy:
-
Polinsky, Cristina
Houston, Chanelle
Vado, Jaynine
Shaikh, Azizahmed
Kohn, Rebecca - Powiązania:
- https://bibliotekanauki.pl/articles/1041279.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
UNC-13
F-box
synaptic neurotransmission
yeast two-hybrid - Opis:
- UNC-13 protein participates in regulating neurotransmitter release. In Drosophila melanogaster, proteasomal degradation controls UNC-13 levels at synapses. Function of the amino-terminal region of a 207 kDa form of Caenorhabditis elegans UNC-13 is unknown. Yeast two-hybrid and secondary yeast assays identified an F-box protein that interacts with this amino-terminal region. As F-box proteins bind proteins targeted for proteasomal degradation, this protein may participate in degrading a subset of UNC-13 proteins, suggesting that different forms of UNC-13 are regulated differently. Yeast assays also identified an exonuclease, a predicted splicing factor, and a protein with coiled-coil domains, indicating that UNC-13 may affect RNA function.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 1; 145-148
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł