- Tytuł:
- The role of serum hyaluronic acid determination in the diagnosis of liver fibrosis
- Autorzy:
-
Gudowska, Monika
Cylwik, Bogdan
Chrostek, Lech - Powiązania:
- https://bibliotekanauki.pl/articles/1038585.pdf
- Data publikacji:
- 2017
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
hyaluronic acid
extracellular matrix
non-invasive marker
cirrhosis
fibrosis
hepatitis - Opis:
- The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases is discussed. Here, we focus on the described changes of hyaluronic acid concentration in the pathological processes of the liver, including alcoholic and non-alcoholic liver diseases. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables its application in laboratory diagnosis.
- Źródło:
-
Acta Biochimica Polonica; 2017, 64, 3; 451-457
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł