Autor: Piechota-Polanczyk, Aleksandra - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line
Autorzy:: Łazarenkow, Andrzej
Michalska, Marta
Gorąca, Anna
Mirowski, Marek
Nawrot-Modranka, Jolanta
Piechota-Polanczyk, Aleksandra
Powiązania:: https://bibliotekanauki.pl/articles/1039590.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: hydrazone
chromone
phosphorohydrazone
HL-60
lipid peroxidation
bFGF
Opis:: Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).
Źródło:: Acta Biochimica Polonica; 2013, 60, 2; 259-262
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin
Autorzy:: Kowalska, Karolina
Habrowska-Górczyńska, Dominika
Neumayer, Christoph
Bolliger, Michael
Domenig, Christoph
Piastowska-Ciesielska, Agnieszka
Huk, Ihor
Piechota-Polanczyk, Aleksandra
Powiązania:: https://bibliotekanauki.pl/articles/1038531.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Cav-1
eNOS
abdominal aortic aneurysm
simvastatin
Opis:: This study was undertaken to verify whether simvastatin modulates Cav-1/eNOS expression, and if this modulation is associated with changes in pro- and anti-inflammatory cytokine and Toll-like receptor 4 (TLR4) level in abdominal aortic aneurysm (AAA). It is a 1:2 case-control study of non-statin (n=12) and simvastatin-treated patients (n=24) who underwent open AAA repair. Simvastatin treatment decreased Cav-1 (p<0.05) and increased eNOS expression (p<0.01) in the AAA wall. These changes might be dose dependent. The changes in Cav-1 and eNOS were associated with a trend towards decreased IL-6 and IL-17 concentration (p>0.05) and increased IL-10 concentration (p=0.055); however, TLR4 expression was unaffected, suggesting that simvastatin influences Cav-1 and eNOS in the AAA wall by other mechanisms. Simvastatin may modulate Cav-1 and eNOS expression in the aneurysmal wall, indicating a potentially beneficial role for statins in AAA patients.
Źródło:: Acta Biochimica Polonica; 2018, 65, 1; 111-118
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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