- Tytuł:
- Effect of tetrazole moiety on coordinating efficiency of deltorphin.
- Autorzy:
-
Łodyga-Chruścińska, Elżbieta
Ołdziej, Stanisław
Micera, Giovanni
Sanna, Daniele
Chruściński, Longin
Olczak, Jacek
Zabrocki, Janusz - Powiązania:
- https://bibliotekanauki.pl/articles/1043323.pdf
- Data publikacji:
- 2004
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
Cu(II) complexes
opiod peptides
tetrazole analogues of deltorphin I - Opis:
- A study of the effect of the tetrazole moiety, a cis-amide bond surrogate, on the Cu(II) coordinating properties of oligopeptides is reported. Insertion of the tetrazole moiety Ψ[CN4] into the peptide sequence of [D-Ala2]deltorphin I changes considerably the coordination ability of the peptide. Potentiometric and spectroscopic results show that if the tetrazole moiety is in a suitable position in the peptide chain, i.e. it follows the second residue, a stable CuL species involving 3N coordination is formed in the physiological pH range. The tetrazole Ψ[CN4] ring provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside a bent peptide backbone. The peptide conformation changes achieved by Cu(II) coordination may be essential for the binding of tetrazole deltorphins at opiate receptors.
- Źródło:
-
Acta Biochimica Polonica; 2004, 51, 1; 93-106
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł