- Tytuł:
- Monitoring of urine nitric oxide (NO) related substrates and immunological competence in hematological malignancy.
- Autorzy:
-
Tanaka, Junko
Koshimura, Kunio
Tsumori, Michihiro
Murakami, Yoshio
Kato, Yuzuru - Powiązania:
- https://bibliotekanauki.pl/articles/1043832.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
pokeweed mitogen
hematological malignancy
urine nitric oxide
phytohemagglutinin - Opis:
- It has been reported that concentrations of neopterin in the urine are changed according to the host immunological conditions. In the present study, we measured urinary concentration of neopterin in patients with malignant hematological disorders and investigated the relationship between urinary neopterin levels and laboratory indices for cellular immunity. Urine neopterin levels were correlated with serum sIL-2R levels in the patients with malignant lymphoma, and inversely correlated with lymphocyte reactivity with ConA in the patients with acute myelocytic leukemia. However, no significant correlation was observed between urine neopterin levels and lymphocyte reactivity with phytohemagglutinin and pokeweed mitogen, CD4/8 ratio, CD56+16+ subset or serum IFN-β levels. In the patients with malignant lymphoma, parallel changes in serum sIL-2R and urine neopterin were observed. The presented results suggest that urine neopterin levels are related to the activation of T cells in malignant lymphoma.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 1; 227-232
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł