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    Wyświetlanie 1-8 z 8
    Tytuł:
    Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.
    Autorzy:
    Zubrzak, Paweł
    Kociołek, Karol
    Smoluch, Marek
    Silberring, Jerzy
    Kowalski, Marek
    Szkudlińska, Barbara
    Zabrocki, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1044066.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunosuppression
    cis-amide bond
    1,5-disubstituted tetrazole ring
    hymenistatin I
    Opis:
    Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3, Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile-Ψ[CN4]-Ala3, Pro3-Ψ[CN4]-Ala4 and Val6-Ψ[CN4]-Alawere synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1151-1154
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of biodiversity of Coprinus comatus using genotyping and metabolic profiling tools
    Autorzy:
    Pawlik, Anna
    Malinowska, Anna
    Siwulski, Marek
    Frąc, Magdalena
    Rogalski, Jerzy
    Janusz, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1038885.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    AFLP
    ITS
    Biolog
    fungal diversity
    Coprinus comatus
    shaggy mane mushroom
    Opis:
    Coprinus comatus strains (CCMs) originating from Poland were identified using ITS region sequencing. Based on the sequences obtained, the genetic relationship between the CCM strains was determined and a clear separation of all strains into two main clusters was obtained. The Coprinus strains were also genetically characterized for the first time by the AFLP technique. The analysis showed that the CCMs separated into four main clusters and a high complication of a UPGMA-based dendrogram was achieved. C. comatus strains included in the analysis displayed an AFLP profile similarity level in the range from 44 to 66%. The highest similarity coefficient, 0.490, was found between CCM12 and CCM13, and the lowest (0.202) between the CCM2 and CCM5 isolates. Biolog FF MicroPlates were applied to obtain data on utilization of 95 carbon sources and mycelial growth. The analysis allowed comparison of the functional diversity of the CCM strains and revealed a broad variability within the analyzed Coprinus species based on substrate utilization profiles. Significant differences (2-48) have been shown in the substrate richness values. The Biolog experiments proved to be a good profiling technology for studying the diversity in shaggy manes due to metabolic differences and demonstrated that all the strains might be considered individually. It is evident that the strain metabolic grouping does not correlate with the grouping based on the ITS sequences and AFLP profiles, however, some similarities may be observed.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 4; 683-689
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prognostic value of perioperative assessment of plasma cardiac troponin I in patients undergoing liver transplantation
    Autorzy:
    Jankowski, Krzysztof
    Trzebicki, Janusz
    Bielecki, Maksymilian
    Łągiewska, Beata
    Kurnicka, Katarzyna
    Koczaj-Bremer, Magdalena
    Pacholczyk, Marek
    Pruszczyk, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1038657.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cardiac troponin I
    liver transplantation
    surgery time
    Opis:
    Abstract. An elevation in plasma cardiac troponins is an indicator of increased perioperative risk in orthopaedic and vascular surgery, however, data on liver transplantation (LTx) are scarce. The aim of the study was to evaluate the prevalence of cardiac troponin I (cTnI) elevation in the perioperative period of LTx, and its potential relationship with 1-year mortality. Material and methods. Analysis included 79 patients with liver cirrhosis. During LTx all patients underwent hemodynamic measurements. cTnI level was determined before the operation, 24, 48 and 72 hours afterwards. One-year mortality was assessed. Results. 12.7% patients died, all during in-hospital period. cTnI level on day 1. was identified as the most promising marker of increased death risk with optimal cut-off value of 0.215 ng/mL (the sensitivity of 60.0%, specificity of 87.0%, positive predictive value of 40.0%, negative predictive value of 93.8%). The most important predictor of cTnI increase was the duration of the LTx procedure followed by amount of packed red blood cells transfused, basic stroke volume index, and cardiac output index. In conclusion: value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following LTx with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 2; 331-337
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Differential stability of mitochondrial mRNA in HeLa cells
    Autorzy:
    Piechota, Janusz
    Tomecki, Rafał
    Gewartowski, Kamil
    Szczęsny, Roman
    Dmochowska, Aleksandra
    Kudła, Marek
    Dybczyńska, Lien
    Stepien, Piotr
    Bartnik, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1041282.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    polyadenylation
    HeLa
    mitochondria
    poly(A) polymerase
    mRNA turnover
    Opis:
    The physiological significance and metabolism of oligoadenylated and polyadenylated human mitochondrial mRNAs are not known to date. After study of eight mitochondrial transcripts (ND1, ND2, ND3, ND5, CO1, CO2, ATP6/8 and Cyt. b) we found a direct correlation between the half-lives of mitochondrial mRNAs and their steady-state levels. Investigation of the mt-mRNA decay after thiamphenicol treatment indicated that three transcripts (ND2, ND3 and Cyt. b) are significantly stabilized after inhibition of mitochondrial translation. Careful analysis one of them, ND3, showed that inaccurate processing of the H-strand RNA precursor may occasionally occur between the ND3 and tRNAArg locus leading to synthesis of ND3 mRNAs lacking the STOP codon. However, analysis of the oligo(A) fraction observed in case of the ND3 indicates that partially polyadenylated mRNAs are linked rather to the transcription process than to the translation-dependent deadenylation. Analysis of ND3 mRNA turnover in cells with siRNA-mediated knock-down of the mitochondrial poly(A) polymerase shows that strongly decreased polyadenylation does not markedly affect the decay of this transcript. We present a model where oligoadenylated mitochondrial transcripts are precursors of molecules containing full length poly(A) tails.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 1; 157-168
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
    Autorzy:
    Blasiak, Janusz
    Przybyłowska, Karolina
    Czechowska, Agnieszka
    Zadrożny, Marek
    Pertyński, Tomasz
    Rykała, Jan
    Kołacińska, Agnieszka
    Morawiec, Zbigniew
    Drzewoski, Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/1043672.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    genetic polymorphism
    RAD51 gene
    RFLP-PCR
    breast cancer
    Opis:
    The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 1; 249-253
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Changes in ATP level and iron-induced ultra-weak photon emission in bull spermatozoa, caused by membrane peroxidation during thermal stress
    Autorzy:
    Gumińska, Maria
    Kędryna, Teresa
    Laszczka, Andrzej
    Godlewski, Marek
    Sławiński, Janusz
    Szczęśniak-Fabiańczyk, Barbara
    Kwiecińska, Teresa
    Rajfur, Zenon
    Wierzuchowska, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/1044974.pdf
    Data publikacji:
    1997
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1997, 44, 1; 131-138
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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