- Tytuł:
- Inhibitory effect of resveratrol on free radical generation in blood platelets
- Autorzy:
-
Olas, Beata
Żbikowska, Halina
Wachowicz, Barbara
Krajewski, Tadeusz
Buczyński, Andrzej
Magnuszewska, Arleta - Powiązania:
- https://bibliotekanauki.pl/articles/1044455.pdf
- Data publikacji:
- 1999
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
resveratrol
blood platelet
free radicals - Opis:
- Resveratrol (3,4',5-trihydroxystilbene), a compound found in many plants, has been shown to prevent coronary heart diseases and to exert a variety of antiinflammatory and anticancerogenic effects. It is effective in lowering the level of serum lipids and in inhibiting platelet aggregation. We evaluated the effect of trans-resveratrol on the production of free radicals in pig blood platelets and showed that resveratrol inhibited the production of different reactive oxygen species (O^·_2H^2O^2, singlet oxygen and organic radicals) measured by the luminol-dependent chemiluminescence in resting platelets (P < 0.05). Resveratrol inhibited also the generation of radicals in platelets activated by thrombin (P < 0.05). Treatment of platelets with resveratrol at concentrations of 6.25 and 12.5 μg/ml caused a statistically insignificant increase in the production of O^·-_2 in these cells, as measured by reduction of cytochrome c; however, at higher doses (25, 50 and 100 μg/ml) resveratrol distinctly reduced the generation of O^·-_2 in platelets (P < 0.05). We suggest that free radicals play an important role in the reduced reactivity of blood platelets induced by resveratrol.
- Źródło:
-
Acta Biochimica Polonica; 1999, 46, 4; 961-966
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł