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Wyszukujesz frazę "Jakubowska, Anna." wg kryterium: Autor

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Molecular basis of inherited predispositions for tumors*
    Autorzy:
    Lubiński, Jan
    Górski, Bohdan
    Kurzawski, Grzegorz
    Jakubowska, Anna
    Cybulski, Cezary
    Suchy, Janina
    Dębniak, Tadeusz
    Grabowska, Ewa
    Lener, Marcin
    Nej, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1043719.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    BRCA1
    inherited tumors
    BRCA2
    gene interactions
    MLH1
    MSH2
    Opis:
    On the basis of literature data and own experience the authors review the current knowledge about the molecular basis of inherited predispositions for tumors. They hypothesize that in the near perspective 5-10 years studies using existing registry data/material and the latest novel technology will allow the identification of the molecular background for the majority of hereditary cancers which will have enormous practical consequences especially for the prevention of malignancies.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 3; 571-581
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice. A multiple case study
    Autorzy:
    Jakubowska, Monika
    Śniegocka, Martyna
    Podgórska, Ewa
    Michalczyk-Wetula, Dominika
    Urbanska, Krystyna
    Susz, Anna
    Fiedor, Leszek
    Pyka, Janusz
    Płonka, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1039526.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    adenocarcinoma
    histological analysis
    metastases
    nude mice
    photodynamic therapy
    zinc pheophorbide a
    Opis:
    Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 323-330
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mutations in the COL1A1 and COL1A2 genes associated with osteogenesis imperfecta (OI) types I or III
    Autorzy:
    Augusciak-Duma, Aleksandra
    Witecka, Joanna
    Sieron, Aleksander
    Janeczko, Magdalena
    Pietrzyk, Jacek
    Ochman, Karolina
    Galicka, Anna
    Borszewska-Kornacka, Maria
    Pilch, Jacek
    Jakubowska-Pietkiewicz, Elzbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038526.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    osteogenesis imperfecta
    COL1A1
    COL1A2
    mutation
    polymorphism
    Opis:
    Although over 85% of osteogenesis imperfecta (OI) cases are associated with mutations in the procollagen type I genes (COL1A1 or COL1A2), no hot spots for the mutations were associated with particular clinical phenotypes. Eight patients that were studied here, diagnosed with OI by clinical standards, are from the Polish population with no ethnic background indicated. Previously unpublished mutations were found in six out of those eight patients. Genotypes for polymorphisms (Sp1 - rs1800012 and PvuII - rs412777), linked to bone formation and metabolism were determined. Mutations were found in exons 2, 22, 50 and in introns 13 and 51 of the COL1A1 gene. In COL1A2, one mutation was identified in exon 22. Deletion type mutations in COL1A1 that resulted in OI type I had no effect on collagen type I secretion, nor on its intracellular accumulation. Also, a single base substitution in I13 (c.904-9 G>T) was associated with the OI type I. The OI type III was associated with a single base change in I51 of COL1A1, possibly causing an exon skipping. Also, a missense mutation in COL1A2 changing Gly→Cys in the central part of the triple helical domain of the collagen type I molecule caused OI type III. It affected secretion of the heterotrimeric form of procollagen type I. However, no intracellular accumulation of procollagen chains could be detected. Mutation in COL1A2 affected its incorporation into procollagen type I. The results obtained shall help in genetic counseling of OI patients and provide a rational support for making informed, life important decisions by them and their families.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 79-86
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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