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Wyszukujesz frazę "Fernando" wg kryterium: Autor


Wyświetlanie 1-3 z 3
Tytuł:
Biased versus unbiased randomness in homo-polymers and copolymers of amino acids in the prebiotic world
Autorzy:
Mosqueira, Fernando
Negron, Alicia
Ramos, Sergio
Polanco, Carlos
Powiązania:
https://bibliotekanauki.pl/articles/1039646.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polarity of amino acids
homo-peptides
prebiotic co-polypeptides
lysine
Markov chain
prebiotic homo polymerization of amino acids
Opis:
The polymerization of amino acids under anhydrous prebiotic conditions was first studied several decades ago. Here we use a stochastic model stressing the relevant role of the polarity of amino acids in the formation of oligopeptides in a prebiotic milieu. Our goal is to outline the predominance of co-polypeptides over homo-polypeptides, resulting not only from the randomness, but also from polarity properties of amino acids. Our results conclude that there was a higher probability of the formation of co-polypeptides than of homo-polymers. Besides, we may hypothesize that the former would have a more ample spectrum of possible chemical functions than homo-polypeptides.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 543-547
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyridine-induced chemical seizure and prevent death in mice
Autorzy:
Brito, Verônica
Rocha, João
Folmer, Vanderlei
Erthal, Fernando
Powiązania:
https://bibliotekanauki.pl/articles/1040644.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
seizure
diphenyl diselenide
selenium
diphenyl ditelluride
4-aminopyridine
lipid peroxidation
Opis:
In this work was investigated the effect of pre-treatment with (PhSe)2 and (PhTe)2 on chemical seizure and 4-aminopyridine-induced lethality in mice. Additionally, lipid peroxidation levels of whole brain after treatment with 4-aminopyridine and effect of pre-treatment with (PhSe)2 and (PhTe)2 on these levels were investigated. Mice were pre-treated with (PhSe)2 or (PhTe)2 (50, 100, or 150 µmol/kg) 30 min before 4-aminopyridine (12 mg/kg) administration. The treatment with 4-aminopyridine caused a significant incidence of seizures (clonic, tonic) and death. Pre-treatment with (PhSe)2 and (PhTe)2 significantly increased the latency for clonic and tonic seizures, and prevented 4-aminopyridine-induced death. Significantly, the pre-treatment with (PhSe)2 or (PhTe)2 increased the latency for clonic seizures in a dose-dependent manner. Additionally, a significant increase was observed in the brain lipid peroxidation level after treatment with 4-aminopyridine, which was significantly inhibited by pre-treatment with 150 µmol/kg (PhSe)2 or (PhTe)2. These results demonstrate that (PhSe)2 and (PhTe)2 counteract the harmful effects of 4-aminopyridine. It is possible that this effect results from modulation of the redox state of N-methyl-d-aspartate receptors and/or of Ca2+ channel activity with subsequent alteration in neurotransmitter release. Importantly, this study provides evidence for anticonvulsant and antioxidant properties of (PhSe)2 and (PhTe)2, which indicates a neuroprotective activity of these compounds.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 125-134
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aza and diaza bioisosteric anthracene-9,10-diones as antitumor agents
Autorzy:
Krapcho, A.
Maresch, Martin
Hacker, Miles
Menta, Ernesto
Oliva, Ambrogio
Giuliani, Fernando
Spinelli, Silvano
Powiązania:
https://bibliotekanauki.pl/articles/1045201.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1995, 42, 4; 427-432
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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