Autor: Deptuła, Magdalena - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Stress granules (SG) and processing bodies (PB) in viral infections
Autorzy:: Malinowska, Magdalena
Niedźwiedzka-Rystwej, Paulina
Tokarz-Deptuła, Beata
Deptuła, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1038793.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: stress granules
processing bodies
viral infection
Opis:: During reaction to stress caused by viral infection, RNA granules are formed in order to protect mRNA. Stress granules (SG) and processing bodies (PB) provide cell homeostasis and mRNA stability. They are formed, for example, during polio virus and MRV (mammalian orthoreovirus) infections. Some viruses, such as influenza virus and HTLV-1 (Human T-lymphotropic virus 1), block the formation of granules. In addition, there are viruses like West Nile Virus, Hepatitis C Virus (HCV) or human Herpes viruses, which influence the functioning of the granules.
Źródło:: Acta Biochimica Polonica; 2016, 63, 2; 183-188
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Cytotoxicity of thermo-responsive polymeric nanoparticles based on N-isopropylacrylamide for potential application as a bioscaffold
Autorzy:: Deptuła, Tobiasz
Warowicka, Alicja
Woźniak, Anna
Grzeszkowiak, Mikołaj
Jarzębski, Maciej
Bednarowicz, Magdalena
Patkowski, Adam
Słomski, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1039109.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: nanoparticles
toxicology
poly-N-isopropylacrylamide
drug delivery system
cytotoxicity
polymers
Opis:: Polymeric nanoparticles based on poly-N-isopropylacrylamide (pNiPAM NPs) and their bio-medical applications have been widely investigated in recent years. These tunable nanoparticles are considered to be great candidates for drug delivery systems, biosensors and bioanalytical devices. Thus, the biocompatibility and toxicity of these nanoparticles is clearly a crucial issue. In this work, the cytotoxicity of thermo-responsive pNiPAM nanoparticles was studied, followed by a detailed analysis of the NPs morphology in growing cell cultures and their 3D structure. Cytotoxic examination was conducted for two cell cultures - HeLa (cervical cancer cell line) and HeK293 (human embryonic kidney cell line), employing MTT (3-4, 5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide) assay and viability tests. We used Cryo-SEM (scanning electron microscopy) and fluorescence microscopy (IN Cell Analyzer) in order to investigate the morphological structure of the polymer network. We show that pNiPAM nanoparticles do not exhibit any cytotoxicity effects on the investigated cell lines. Additionally, we report that the pNiPAM nanoparticle based scaffold promotes cell growth.
Źródło:: Acta Biochimica Polonica; 2015, 62, 2; 311-316
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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