- Tytuł:
- Mitochondrial DNA in pediatric leukemia patients
- Autorzy:
-
Kodroń, Agata
Ghanim, Magda
Krawczyk, Katarzyna
Stelmaszczyk-Emmel, Anna
Tońska, Katarzyna
Demkow, Urszula
Bartnik, Ewa - Powiązania:
- https://bibliotekanauki.pl/articles/1038705.pdf
- Data publikacji:
- 2017
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
pediatric ALL
mtDNA
chemotherapy - Opis:
- Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children. In this study we compared mitochondrial sequence variation in the D-loop region and in 5 genes of mtDNA in bone marrow samples of 6 pediatric patients with ALL at various stages of therapy. We found several common polymorphisms and one variant at position 3688 whose level varied during leukemia treatment. Our results suggest that mitochondrial DNA mutations, whose levels change during patient treatment, could be potential biomarkers for monitoring treatment efficacy and disease progression.
- Źródło:
-
Acta Biochimica Polonica; 2017, 64, 1; 183-187
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł