Wszystkie pola: Petra - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Mass spectrometric analysis of head-to-tail connected cyclic peptides.
Autorzy:: Macht, Marcus
Pelzing, Matthias
Palloch, Petra
Sauerland, Volker
Volz, Jürgen
Powiązania:: https://bibliotekanauki.pl/articles/1044055.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: electrospray
post source decay
MALDI
mass spectrometry
peptide sequencing
Opis:: Tandem mass spectrometry is an extremly useful tool for high sensitive sequence identification of peptides. In the case of cyclic peptides fragmentation can easily be performed for sequence analysis. However, analysis is usually tedious due to the lack of a defined beginning and end of the sequence. Since cyclic peptides are a highly interesting class of compounds especially for the pharmaceutical industry, ways have to be found to identify their structures. In this work we demonstrate how software and dedicated analytical strategies can be used for detailed analysis of these substances.
Źródło:: Acta Biochimica Polonica; 2001, 48, 4; 1109-1112
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation.
Autorzy:: May, Petra
Schniertshauer, Ute
Gerhartz, Claudia
Horn, Friedemann
Heinrich, Peter
Powiązania:: https://bibliotekanauki.pl/articles/1043431.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: immediate early genes
STAT transcription factors
acute phase proteins
gp130
Opis:: Interleukin-6 is a potent inducer of acute-phase response gene transcription. The intracellular signal transduction mechanisms by which this and other biological effects of the cytokine are achieved include activation of the JAK-STAT signaling pathway. More specifically, activation of the signal transducers and activators of transcription STAT1, 3, and 5 in response to IL-6 has been described. We examined the relative potency of these three STAT factors for the activation of acute-phase gene promoters in HepG2 cells in a reporter gene-based assay, where specific STAT factors could be activated via recombinant receptor constructs bearing different STAT-recruiting modules. These experiments indicate that amongst the STAT factors known to be activated by IL-6 STAT3 is the most potent activator of acute-phase gene transcription.
Źródło:: Acta Biochimica Polonica; 2003, 50, 3; 595-601
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 3.

Tytuł:: Frequencies of HLA-DQ2 and HLA-DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population
Autorzy:: Wroblova, Katerina
Kolorz, Michal
Pav, Igor
Horakova, Zuzana
Filipova, Petra
Bartos, Milan
Bartosova, Ladislava
Powiązania:: https://bibliotekanauki.pl/articles/1039366.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: coeliac disease
HLA haplotype
HLA-DQ2
HLA-DQ8
Czech and Slovak population
Opis:: Coeliac disease is an autoimmune disorder with genetic predisposition. The aim was to determine the frequency of HLA-DQ2 and HLA-DQ8 in Czech and Slovak patients and the healthy population. The study included 127 patients and 66 healthy volunteers. HLA-DQ2 was identified in 85.03% patients, and 24.24% healthy individuals (P=0.0001; OR17.7632; CI=8.4347-37.4088). HLA-DQ8 was identified in 11.81% patients and 15.5% healthy individuals. HLA-DQ8 occurred more often in HLA-DQ2-negative patients compared to HLA-DQ2-positive patients (P=0.0494; OR3.5; CI 1.0428-11.7468). At least one of the studied HLA-variants was found more often in patients than in healthy individuals (P=0.0001; OR58.8; CI 7.6856-449.8602).
Źródło:: Acta Biochimica Polonica; 2014, 61, 1; 191-193
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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