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Wyszukujesz frazę "energy-dependent state" wg kryterium: Temat


Wyświetlanie 1-3 z 3
Tytuł:
Factor of ‘power’ in the European vector of Russia’s foreign policy strategy and the globalization of energy policy
Autorzy:
Slobodian, Nataliia
Powiązania:
https://bibliotekanauki.pl/articles/958009.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Instytut Historii im. Tadeusza Manteuffla PAN w Warszawie
Tematy:
energy factor
energonomy
militarization of energy policy of the Russian Federation
sectoral sanctions
energy-dependent state
czynnik energetyczny
energonomia
czynnik siły w polityce energetycznej Federacji Rosyjskiej
sankcje sektorowe
państwa zależne energetycznie
Opis:
In the modern world of energy dependent economies, the energy component acts as a determining factor in making strategic and political decisions in the geopolitical dimensions. The article’s central interest focuses on the economic origins and financial base of the energy component of Russia’s aggressive foreign policy in the European space. It contains the qualitative and quantitative indicators of the structure of modern Russian energy market and presents the research of sources of economic basis of Russia’s military overcapacity and correlation between the size of defense spending and state budget revenues of the Russian Federation in the energy sector. Based on the findings of this study, possible ways and measures can be modeled to create an effective financial‑economic and political‑strategic system of the EU states to deter the current course of the Kremlin tight energy policy on the territory of European countries.
Źródło:
Studia z Dziejów Rosji i Europy Środkowo-Wschodniej; 2015, 50, 1
2353-6403
1230-5057
Pojawia się w:
Studia z Dziejów Rosji i Europy Środkowo-Wschodniej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ
Autorzy:
Nemeikaitė-Čėnienė, Aušra
Dringelienė, Aldona
Šarlauskas, Jonas
Čėnas, Narimantas
Powiązania:
https://bibliotekanauki.pl/articles/1041349.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
non-cross resistant antitumour benzoperimidines and anthrapyridones
ATP-dependent efflux
erythrocytes
multidrug resistance
energy state
Opis:
We aimed to characterize the role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by antitumour quinones RH1 (2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone) and MeDZQ (2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone). Digitonin-permeabilized FLK cells catalyzed NADPH-dependent single- and two-electron reduction of RH1 and MeDZQ. At equitoxic concentrations, RH1 and MeDZQ induced apoptosis more efficiently than the nonalkylating duroquinone or H2O2. The antioxidant N,N'-diphenyl-p-phenylene diamine, desferrioxamine, and the inhibitor of NQO1 dicumarol, protected against apoptosis induction by all compounds investigated, but to a different extent. The results of multiparameter regression analysis indicate that RH1 and MeDZQ most likely induce apoptosis via NQO1-linked formation of alkylating species but not via NQO1-linked redox cycling.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 937-942
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes
Autorzy:
Nowak, Robert
Baranowska-Bosiacka, Irena
Stefańska, Barbara
Machaliński, Bogusław
Hłyńczak, Alina
Tarasiuk, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1041354.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
non-cross resistant antitumour benzoperimidines and anthrapyridones
ATP-dependent efflux
erythrocytes
multidrug resistance
energy state
Opis:
Multidrug resistance (MDR) of tumour cells is related to the overexpression of ATP-dependent pumps responsible for the active efflux of antitumour agents out of resistant cells. Benzoperimidine and anthrapyridone compounds exhibit comparable cytotoxic activity against sensitive and MDR tumour cells. They diffuse extremely rapidly across the plasma membrane and render the ATP-dependent efflux inefficient. Such uptake could disturb an energy metabolism of normal cells possessing an elevated level of ATP-dependent proteins, especially erythrocytes having a high level of the MRP1, MRP4 and MRP5 proteins. In this study the effect of five antitumour agents: benzoperimidine (BP1), anthrapyridones (CO1, CO7) and reference drugs used in the clinic: doxorubicin (DOX) and pirarubicin (PIRA), on the energetic state in human erythrocytes has been examined. These compounds have various types of structure and kinetics of cellular uptake (slow - DOX, CO7, moderate - PIRA, fast - BP1, CO1) resulting in their different ability to saturate ATP-dependent transporters. The energetic state of erythrocytes was examined by determination of purine nucleotide contents (ATP, ADP, AMP), NAD+ and values of adenylate energy charge (AEC) using an HPLC method. It was found that the level of nucleotides as well as the AEC value of erythrocytes were not changed during 24 h of incubation with these agents independently of their structure and ability to saturate ATP-dependent pumps. This is a very promising result in view of their potential use in the clinic as antitumour drugs against multidrug resistant cancers.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 953-957
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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