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    Wyświetlanie 1-12 z 12
    Tytuł:
    Tissue remodelling in chronic rhinosinusitis – review of literature
    Autorzy:
    Radajewski, Kamil
    Wierzchowska, Małgorzata
    Grzanka, Dariusz
    Antosik, Paulina
    Zdrenka, Marek
    Burduk, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1397806.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    chronic rhinosinusitis
    nasal polyps
    tissue remodeling
    Opis:
    CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines – IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular the β1 subunit, was identified as the main factor involved in the remodelling of tissue stroma. In conjunction with continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodelling in the chronic processes of paranasal sinuses.
    Źródło:
    Polish Journal of Otolaryngology; 2019, 73, 5; 1-4
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Current issues in the diagnostics of paediatric chronic rhinosinusitis
    Autorzy:
    Standylo, A.
    Obuchowska, A.
    Horoch, T.
    Mielnik-Niedzielska, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098538.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    pediatrics
    diagnostics
    chronic rhinosinusitis
    child
    adolescent
    otolaryngology
    Opis:
    Introduction and objective. Paediatric chronic rhinosinusitis (PCRS) is a common disease in children. It is defined as an ongoing inflammation of the nasal cavity and sinuses lasting for over 12 weeks. Due to prevalence in the population, PCRS is associated with a high healthcare and financial burden. During the examination, attention should be paid to symptoms that may suggest chronic rhinosinusitis (CRS), because it may be underdiagnosed. Due to the chronicity of the inflammatory process and the similarity of symptoms to allergic rhinitis and adenoid hypertrophy, diagnosis and treatment are difficult. In this review, guidelines from The European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2020 and recent literature reports from Medline and Scopus database are analysed. Materials and methods. Information was obtained through a review and analysis of the PubMed Medline and Scopus databases. Brief description of the state of knowledge. Diagnostic difficulties with CRS can be caused by many factors. The EPOS guidelines recommend flexible or rigid nasal endoscopy as a preliminary objective method to assist in the recognition of CRS. Computed tomography (CT) is not recommended for routine management; therefore, CT is the gold standard for imaging when establishing a PCRS diagnosis or preparing for sinus surgery. The use of conventional X-ray imaging for chronic rhinosinusitis is limited and not recommended. Conclusions. Understanding the symptoms of chronic rhinosinusitis is of utmost importance in daily practice. Early initial assessment of symptoms in children with a high probability of CRS allows for early diagnosis and reduces the need for endoscopic and imaging examination.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 3; 134-136
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of nasal mucosa irritants on the occurrence of chronic rhinosinusitis without /and with polyps
    Autorzy:
    Olszewska, Aleksandra
    Niewiadomski, Piotr
    Olszewski, Jurek
    Powiązania:
    https://bibliotekanauki.pl/articles/1397254.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    chronic rhinosinusitis with/without nasal polyps
    irritants
    nasal mucosa
    Opis:
    Introduction: The aim of the study was to assess the effect of nasal mucosa irritants on the occurrence of chronic rhinosinusitis without/and with nasal polyps. Material and methods: The study involved 100 adult participants, including 39 women and 61 men, aged 21–68, diagnosed and treated at the Department of Otolaryngology, ENT Oncology, Audiology and Phoniatrics at the University Clinical Hospital WAM in Łódź. Based on the otorhinolaryngological and imaging (CT) tests they were divided into two groups: I – 50 patients, including 23 women and 27 men, aged 21–64 – with chronic rhinosinusitis without nasal polyps, II – 50 patients, including 16 women and 34 men, aged 22–68 – with chronic rhinosinusitis with nasal polyps. The control group consisted of 50 people (group III), including 25 women and 25 men, aged 18–30, students of the Faculty of Military Medicine at the Medical University of Lodz. All respondents completed a prepared questionnaire consisting of 17 questions addressed in the form of an anonymous interview among patients treated in the Department of Otolaryngology, ENT Oncology, Audiology and Phoniatrics. Results: The conducted surveys indicate the impact of the following factors in pathogenesis of chronic rhinosinusitis without/ with nasal polyps: exogenous factors (viruses, bacteria, fungi, drugs, injuries, toxic substances, environmental pollution), general endogenous factors (allergy, hypersensitivity to acetylsalicylic acid and its derivatives, hormonal disorders, supraesophageal reflux disease, granulation disease, immunity disorders, local endogenous factors. Conclusions: In the examined material, patients with chronic rhinosinusitis without/and nasal polyps in most cases are in the age range 51–60 years and over 60 years, they most often live in large cities over 250 thousand inhabitants, suffer from allergic rhinorhinitis in 38.0% in group I and 36.0% in group II, rapid temperature changes and dry air have a negative impact on comfort of breathing. The conducted surveys confirm that the cause of chronic rhinosinusitis with polyps is multifactorial, but a significant factor affecting typical tissue remodeling in this disease is long-term breathing of polluted atmospheric air.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 1; 36-44
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Functional endoscopic sinus surgery (FESS) in unilateral sinus disease
    Autorzy:
    Mielcarek-Kuchta, Daniela
    Simon, Karolina
    Kondratowicz, Dawid
    Łukomska, Zofia
    Rybak-Korytowska, Aleksandra
    Powiązania:
    https://bibliotekanauki.pl/articles/1398482.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    unilateral sinus disease
    FESS
    chronic rhinosinusitis
    inverted papilloma
    mycosis
    Opis:
    Background: Unilateral sinus disease (USD) occurs in 23 % of all cases. It is believed that it is mainly associated with cancer development. Retrospective data from large rhinological centers show that the most common USD is chronic rhinosinusitis (CRS), followed by mycosis, inverted papilloma and finally cancer, but only in a small percent of cases. The aim of the study: The analysis of USD in the group of patients who underwent FESS at the secondary referral center. Material and Method: The retrospective study of patients treated for USD in the Department of Otolaryngology in the Provincial Hospital in Poznan between June 2014 and June 2016. The analysis includes age, sex, the localization of lesions, histopathological and microbiological results, an extension of the surgery and treatment results. Results: Over the analyzed period of time, 415 FESS for chronic sinusitis were performed. In this group, 83 patients underwent surgery for USD. There were 35 women and 48 men.CRS was found in 48 cases, mycosis in nine cases, 12 patients were operated for non-malignant tumors, such as inverted papilloma (9), osteoma (2) and fibrosis tumor(1); seven patients had a choanal polyp and two of them had a foreign body in maxillary sinus – a tooth root lying loose. Four patients were diagnosed with a hypoplastic maxillary sinus and one patient suffered from frontal sinus pyocele. One side endoscopic opening of all sinuses was performed in the group with CRS, endoscopic medial maxillectomy was conducted in patients with inverted papilloma, and an isolated opening of the affected sinus was performed in the cases with mycosis. Conclusions: USD must be always suspected of malignant degeneration until proven otherwise. Endoscopic sinus surgery with the use of angled scope allows for the removal of even very extensive lesions. In our opinion, the extent of operation is determined by the nature of pathology. While extensive surgery is recommended in patients with inverted papilloma, a limited procedure should be performed in those with isolated mycosis.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 5; 29-35
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A randomized, double-blind, placebo-controlled study to investigate the use of bacteriophages in patients with chronic rhinosinusitis with nasal polyps
    Autorzy:
    Dobretsov, Konstantin Grigorievich
    Kolenchukova, Oxana
    Sipkin, Alexander
    Bellussi, Luisa Maria
    Ciprandi, Giorgio
    Passali, Desiderio
    Powiązania:
    https://bibliotekanauki.pl/articles/23203235.pdf
    Data publikacji:
    2021-06-30
    Wydawca:
    Index Copernicus International
    Tematy:
    bacteria
    bacteriophages
    chronic rhinosinusitis with nasal polyps
    cytokines
    local treatment
    Opis:
    Introduction: A randomized, double-blind, placebo-controlled study investigates the use of bacteriophages in the treatment of chronic rhinosinusitis with nasal polyps. Material and methods: 40 adult patients with chronic rhinosinusitis with nasal polyps were examined. All patients underwent functional endoscopic sinus surgery. After the surgery, 20 patients were administered an intranasal gel with bacteriophage mixture (Otofag, Micromir, Russia) twice a day for ten weeks, while 20 other patients received a placebo solution. Results: On the 10th day, IL-1β secretion diminished (63 mg/ml versus 440 mg/ml in control). There was a decrease in the total number of microorganisms and Enterobacteriaceae (5.7 x 106 CFU/ml versus 1.2 x 109 CFU/ml in the control group) and the absence of Streptococci (versus 2.1 x 109 CFU/ml in control) was noted on the 30th day of treatment in the group receiving bacteriophage mixture. On the 10th day, a decrease in the activity of secretory IL-1β and IL-8 strongly and very strongly correlated with a total number of microorganisms (r = 0.7; r = 0.9, respectively), as well as a decrease in the activity of secretory IL-8 correlated with the number of Enterobacteriaceae (r = 0.72) and Staphylococci (r = 0.65) in the experimental group treated with bacteriophages. On the 30th day, the decrease in serum IL-1β significantly correlated with the total number of microorganisms (r = 0.80) and Enterobacteriaceae (r = 0.90) in the experimental group. Conclusions: The administration of bacteriophages restored the balance of microorganisms in the nasal cavity and decreased inflammatory response in chronic rhinosinusitis with nasal polyps. Changes such as an inflammation dampening could potentially contribute to reducing recurrent growth of polyp tissue in the future.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 6; 33-37
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of bacterial resistance during treatment with topical gentamicin for chronic rhinosinusitis in patients with cystic fibrosis and primary ciliary dyskinesis. Retrospective case series
    Autorzy:
    Kisiel, Marta
    Sjölander, Isabella
    Klar, Agnes
    Asplund Stenkvist, Monika
    Laurell, Göran
    Powiązania:
    https://bibliotekanauki.pl/articles/1397315.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    chronic rhinosinusitis
    cystic fibrosis
    gentamycin nasal spray
    gentamycin resistance
    primary ciliary dyskinesis
    Opis:
    Background: The management of chronic rhinosinusitis (CRS) in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) is still a challenge. At our institution we have used gentamycin nasal spray, extemporaneously produced, for prophylactic treatment of moderate-to-severe CRS. The aim of this study was to investigate the gentamycin susceptibility of bacteria in sputum samples in CF and PCD patients treated for CRS. Methodology: Patients with CF and PCD who were prescribed gentamycin nasal spray for CRS and had sputum bacterial cultures taken pre-treatment and followed-up at least once after ≥6 months were retrospectively included. Microbiological data were descriptively analysed in terms of bacterial species and resistance to gentamycin. Results: A case series of 17 CF and 12 PCD patients passed the inclusion criteria. Of those cases, three (18%) CF patients and one (8%) PCD patient developed resistance to gentamycin during treatment with gentamycin nasal spray. In all four cases, the resistant bacterial isolates were P. aeruginosa. Additionally, two CF patients already had P. aeruginosa isolates resistant to gentamycin in the pre-treatment culture. In further two CF patients, the multi-resistant Burgdorferi cepacia complex, including gentamycin resistance, was identified. P. aeruginosa and S. aureus in CF and P. aeruginosa and H. influenza in PCD were the predominant bacterial species. Conclusions: The study showed that there was moderate incidence of gentamycin resistance in CF and PCD patients at our institution. However, further prospective studies are needed to confirm the outcomes.
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 3; 33-40
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    EPOS2020: What’s new for physician practitioners?
    Autorzy:
    Arcimowicz, Magdalena
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1399060.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    acute rhinosinusitis
    chronic rhinosinusitis
    diagnostics
    epidemiology
    integrated care pathways
    nasal polyps
    rhinitis and paranasal sinusitis
    treatment
    Opis:
    The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 also abbreviated to EPOS2020, is the new edition of the European document devoted to the broadly understood topic of inflammation of the nasal mucosa and paranasal sinuses. The first edition appeared in 2005, followed by further editions in 2007 and 2012. In February 2020, we received the latest version, extended, somewhat modified, expanded to include the latest research and meta-analysis in the fields of: rhinology, rhinosurgery, epidemiology and reports on comorbidities. A completely new division of chronic sinusitis was presented. Recommendations based on the highest quality evaluations, resulting from the publication of the last eight years, also introduce a system based on integrated care pathways, or ICP in sinusitis. Chapters on pediatric aspects and sinus surgery have been expanded. EPOS2020 is addressed not only to doctors, but also to: nurses, pharmacists, other healthcare workers, as well as patients themselves, who often make the first attempts at treatment with OTC preparations, frequently based on the recommendations of pharmacists. The latest EPOS also specifies directions for further lines of research in the broadly understood field of rhinosinusitis.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2020, 9, 2; 7-17
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of the effect of inflammatory changes and allergic reaction on TAS2R38 receptor expression in patients with chronic sinusitis (CRS)
    Autorzy:
    Piskadło-Zborowska, Karolina
    Stachowiak, Małgorzata
    Sarnowska, Elżbieta
    Jowik, Rafał
    Dżaman, Karolina
    Powiązania:
    https://bibliotekanauki.pl/articles/1397310.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    bitter taste receptor
    chronic rhinosinusitis
    TAS2R38 gene
    TAS2R38 receptor
    Opis:
    Background: Chronic rhinosinusitis (CRS) is one of the most common health complaints affecting 15% of the world’s population. Recent reports confirm the participation of sensory organs in the defense process against pathogenic microorganisms. The bitter taste receptor TAS2R38 is described to play a role in the upper airway defense system. Purpose: The purpose of this study was to assess the function of the bitter taste receptor in correlation with the severity of CRS, sensory organ disorders and allergic reaction. Material and method: The study contained 100 patients undergoing nasal surgery, divided into two groups: CRS with and without nasal polyps. The control group consisted of patients undergoing septoplasty after excluding rhinosinusitis. Sinus mucosa samples obtained during surgery were used to assess TAS2R38 expression using immunohistochemistry. The IgE level was indicated from blood samples collected from patients. The Sniffin’ Sticks Test was performed. Results: CRS patients had higher expression of TAS2R38 receptor compared to controls (p = 0.0175). A statistically significantly higher TAS2R38 H-score in nasal mucosa was found among patients with a higher inflammation process in CT scan (p = 0.001), higher IgE level (p = 0,04) and an abnormal result of the Sniffin’ Sticks Test. Conclusions: Patients with CRS had significant TAS2R38 receptor overexpression correlating with the severity of inflammatory changes in CT scans, abnormal perception of smells and higher IgE level. A cumulative impact was found between the inflammatory changes, smell disfunction and the severity of subjective symptoms of CRS (according to EPOS) and the intensity of cell staining (index H-score).
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 5; 17-23
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biologicals in the treatment of chronic rhinosinusitis with nasal polyps – position of the Polish Society of Otorhinolaryngologists – Head and Neck Surgeons and the Polish Society of Allergology experts
    Leki biologiczne w leczeniu przewlekłego zapalenia błony śluzowej nosa i zatok przynosowych z polipami nosa – stanowisko ekspertów Polskiego Towarzystwa Otorynolaryngologów Chirurgów Głowy i Szyi oraz Polskiego Towarzystwa Alergologicznego
    Autorzy:
    Jurkiewicz, Dariusz
    Kupczyk, Maciej
    Brożek-Mądry, Eliza
    Rapiejko, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/27320992.pdf
    Data publikacji:
    2023-10-03
    Wydawca:
    Index Copernicus International
    Tematy:
    biological treatment
    chronic rhinosinusitis
    T2-diseases
    choroby T2-zależne
    leki biologiczne
    przewlekłe zapalenie zatok przynosowych
    Opis:
    Chronic rhinosinusitis with nasal polyps (CRSwNP) has a significant impact on the well-being and social functions of the patient. The generalized inflammatory process with the formation of nasal polyps and excess eosinophils in the mucosa of the paranasal sinuses is called type 2 inflammation, which is mediated by Th2 lymphocytes – cells of the immune system responsible for chronic inflammatory processes. Today, we also know the key pro-inflammatory mediators against which new drugs have been developed, the so-called biological drugs, are produced in cell lines. In this document, we present currently available biologicals approved for the treatment of patients with T2-related chronic rhinosinusitis.
    Przewlekłe zapalenie błony śluzowej nosa i zatok przynosowych z polipami nosa (PZZPzPN) wywiera duży wpływ na samopoczucie i funkcje społeczne chorego. Uogólniony proces zapalny przebiegający z powstawaniem polipów nosa i nadmiarem eozynofilów w obrębie błony śluzowej zatok przynosowych to zapalenie typu 2., w którym pośredniczą limfocyty Th2 – komórki układu immunologicznego, odpowiadające za przewlekłe procesy zapalne. Dziś znamy też kluczowe mediatory prozapalne, przeciwko którym powstały nowe leki, tzw. leki biologiczne, wytwarzane w liniach komórkowych. W dokumencie przedstawiamy dostępne, w obecnej chwili, leczenie biologiczne zatwierdzone do leczenia pacjentów z T2 – zależnym przewlekłym zapaleniem zatok przynosowych.
    Źródło:
    Polish Journal of Otolaryngology; 2023, 77, 2; 1-11
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The importance of herbal medications in the treatment of rhinosinusitis in adults and children: an example of a five-ingredient herbal medicine
    Znaczenie leków roślinnych w leczeniu zapalenia błony śluzowej nosa i zatok przynosowych u dorosłych i dzieci na przykładzie 5-składnikowego leku roślinnego
    Autorzy:
    Markowski, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/27320988.pdf
    Data publikacji:
    2023-03-10
    Wydawca:
    Index Copernicus International
    Tematy:
    acute post-viral rhinosinusitis
    acute rhinosinusitis
    acute viral rhinosinusitis
    bacterial rhinosinusitis
    BNO 1016
    chronic rhinosinusitis
    Sinupret® extract
    Sinupret® treatment of rhinosinusitis
    bakteryjne zapalenie zatok przynosowych
    leczenie zapalenia zatok
    ostre powirusowe zapalenie zatok przynosowych
    ostre zapalenie zatok przynosowych
    przewlekłe zapalnie zatok przynosowych
    Sinupret®
    Opis:
    This review paper presents current recommendations for the treatment of acute and chronic rhinosinusitis according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2020, EPOS 2020. A particularly important and new element of these recommendations is to emphasize the role of phytotherapy as a rational treatment method, documented by a randomized, double-blind placebo-controlled trial (DBPC). An example of rational phytotherapy of rhinosinusitis is the BNO 1016 formulation recommended in EPOS 2020, known under the trade name of Sinupret®. Each of the pharmaceutical forms of BNO 1016 – coated tablets (powdered drug; dry extract) and oral drops (ethanol extract), is produced on the basis of the same combination of 5 herbal substances such as: gentian root (Gentianae radix), primrose flower (Primulae flos), sorrel herb (Rumicis herba), elderflower (Sambuci flos) and verbena herb (Verbenae herba). BNO 1016 has the status of a drug with well-established therapeutic use, with efficacy and safety confirmed in numerous clinical and preclinical studies. Used in the treatment of acute uncomplicated rhinosinusitis BNO 1016 has antiviral, secretolytic, anti-inflammatory and antibacterial effects confirmed in pharmacological studies. Importantly, the drug Sinupret® can be used in different age groups and therapeutic regimens (mono- and polytherapy), at any stage of sinusitis – from cold disease to bacterial rhinosinusitis (in combination with other drugs).
    Niniejsza praca przeglądowa przedstawia aktualne zalecenia leczenia ostrego i przewlekłego zapalenia zatok przynosowych wg Europejskich Wytycznych na temat Zapalenia Zatok Przynosowych i Polipów Nosa, które zostały opublikowane na początku 2020 roku (ang. European Position Paper on Rhinosinusitis and Nasal Polyps 2020; EPOS 2020). Szczególnie istotnym i nowym elementem tych wytycznych jest podkreślenie roli fitoterapii jako racjonalnej metody leczenia, udokumentowanej randomizowanymi badaniami klinicznymi z podwójnie ślepą próbą z kontrolą placebo (ang. double-blind placebo-controlled trial; DBPC). Przykładem racjonalnej fitoterapii zapalenia zatok przynosowych jest rekomendowana w EPOS 2020 formulacja BNO 1016, znana pod nazwą handlową Sinupret®. Każda z postaci farmaceutycznych BNO 1016 – tabletki drażowane (sproszkowany lek; suchy wyciąg) oraz krople doustne (wyciąg etanolowy) – wyprodukowana jest na bazie tego samego złożenia 5 substancji roślinnych, takich jak: korzeń goryczki (Gentianae radix), kwiat pierwiosnka (Primulae flos), ziele szczawiu (Rumicis herba), kwiat bzu czarnego (Sambuci flos) i ziele werbeny (Verbenae herba). BNO 1016 ma status leku o ugruntowanym zastosowaniu leczniczym, skuteczności i bezpieczeństwie stosowania potwierdzonych w licznych badaniach klinicznych i przedklinicznych. Stosowany w leczeniu ostrego niepowikłanego zapalenia zatok przynosowych BNO 1016 wykazuje potwierdzone w badaniach farmakologicznych działanie: przeciwwirusowe, sekretolityczne, przeciwzapalne oraz przeciwbakteryjne. Co ważne, lek Sinupret® może być podawany w różnych grupach wiekowych i schematach terapeutycznych (mono- i politerapia), na każdym etapie zapalenia zatok, począwszy od choroby przeziębieniowej, skończywszy na bakteryjnym zapaleniu zatok przynosowych (w skojarzeniu z innymi lekami).
    Źródło:
    Polish Journal of Otolaryngology; 2023, 77, 1; 1-8
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chronic rhinosinusitis in children
    Autorzy:
    Zielnik-Jurkiewicz, Beata
    Powiązania:
    https://bibliotekanauki.pl/articles/1400060.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    rhinosinusitis
    chronic
    children
    treatment
    Opis:
    CRS symptoms in children can be mild and uncharacteristic. The disease is multifactorial, and therefore requires a multifaceted, multidisciplinary approach. Treatment of CRS in children is difficult, infections often recur, and treatment methods are often ineffective. In children, surgery is performed infrequently, only when other therapies have failed. The first stage of surgery is adenoidectomy. Functional endoscopic surgery of the paranasal sinuses may be considered if no improvement of the patient after exhausting all possibilities of conservative treatment.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 26-34
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zapalenie błony śluzowej nosa i zatok przynosowych – jedno z najczęstszych zakażeń gornych drog oddechowych
    Rhinosinusitis – one of the most common infections of the upper respiratory tract
    Autorzy:
    Wachnicka-Bąk, Anna
    Lipińska-Opałka, Agnieszka
    Będzichowska, Agata
    Kalicki, Bolesław
    Jung, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033289.pdf
    Data publikacji:
    2014
    Wydawca:
    Medical Communications
    Tematy:
    acute
    chronic
    diagnostic criteria
    rhinosinusitis
    treatment
    zapalenie błony śluzowej nosa i zatok przynosowych
    ostre
    przewlekłe
    kryteria diagnostyczne
    leczenie
    Opis:
    Rhinosinusitis is a one of the most common upper respiratory tracts diseases, which affects from 6% to 15% of human population. Presence of pathogens, ostial obstruction and impaired drainage from sinuses have vital importance in illness development. Moreover, the risk of rhinosinusitis is increased with the associated risk factor such as: allergic rhinitis, anatomic defects of nasal septum and nasal cavity, primary ciliary dyskinesia, gastrooesophageal reflux, laryngopharyngeal reflux, congenital and acquired immunodeficiencies, cigarette smoke exposure. Because of the time of the clinical symptoms duration we divided the disease into acute and chronic. Symptoms of less than 12 weeks duration are considered acute and it is definitely more likely associated with viral infection. Persistence of signs and symptoms for more than 12 weeks is diagnosed as chronic rhinosinusitis and is often complicated by bacterial infection (mainly Streptococcus pneumoniae and Haemophilus influenzae). No single symptom or sign is an accurate predictor as they are varied and depends on age and inflammation localization. The diagnosis of rhinosinusitis is initially a clinical one. Radiologic confirmation is required only if the patient does not improve with empiric therapy or if she/he appears extremely ill, not as a primary diagnostic tool. The vast majority of patients should be effectively treated by decongestants, analgesics, antipyretics, mucolytics and oral rehydration. The use of antibiotics should be considered if there is no improvement only after 7–10 days of symptomatic treatment. In presented article we also describe two cases of children hospitalized in 2013 in Paediatric, Nephrology and Allergology Clinic, Military Institute of Medicine, which quite good illustrate diagnostic problems caused by symptoms diversification and the recurrence of the disease.
    Zapalenie błony śluzowej nosa i zatok przynosowych (rhinosinusitis) to jedna z najczęstszych chorób górnych dróg oddechowych, dotykająca szacunkowo 6–15% ogółu populacji. Dla rozwoju schorzenia konieczna jest obecność zjadliwych szczepów patogennych oraz wewnątrzzatokowe gromadzenie wydzieliny śluzowej, spowodowane zaburzeniami drożności jednostki ujściowo-przewodowej zatok. Ponadto do czynników ryzyka wystąpienia zapalenia należą: alergiczny nieżyt nosa, wady anatomiczne przegrody i ściany bocznej nosa, wrodzone zaburzenia transportu rzęskowego, refluks żołądkowo-przełykowy, refluks krtaniowo-gardłowy, wrodzone i nabyte niedobory odporności, ekspozycja na dym tytoniowy. Ze względu na czas trwania objawów wyróżnia się postać ostrą i przewlekłą schorzenia. Najczęstszą pierwotną przyczyną ostrego zapalenia błony śluzowej nosa i zatok przynosowych (objawy choroby trwają krócej niż 12 tygodni) są wirusy. U chorych skarżących się na dolegliwości trwające powyżej 12 tygodni istnieje podstawa do rozpoznania zapalenia przewlekłego, w którym przeważa etiologia bakteryjna (głównie Streptococcus pneumoniae i Haemophilus influenzae). Objawy są różnorodne, zależne od wieku i lokalizacji zmian zapalnych. Diagnozę stawia się na podstawie wywiadu i badania przedmiotowego; badania obrazowe nie powinny być traktowane jako wstępne, rutynowe badania diagnostyczne. Postępowanie terapeutyczne polega na zmniejszaniu obrzęku i przekrwienia błony śluzowej, łagodzeniu bólu i gorączki, nawadnianiu organizmu oraz ewakuacji zalegającej wydzieliny. W przypadku gdy po 7–10 dniach leczenia objawowego nie następuje poprawa, należy zastosować antybiotykoterapię ogólną. W prezentowanej pracy przedstawiamy dwa opisy dzieci hospitalizowanych w 2013 roku w Klinice Pediatrii, Nefrologii i Alergologii Dziecięcej WIM, dość dobrze obrazujące trudności diagnostyczne spowodowane różnorodnością objawów klinicznych, a także problem nawrotowości choroby.
    Źródło:
    Pediatria i Medycyna Rodzinna; 2014, 10, 1; 25-31
    1734-1531
    2451-0742
    Pojawia się w:
    Pediatria i Medycyna Rodzinna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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