Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "chiral recognition" wg kryterium: Temat

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-2 z 2
    Tytuł:
    Application of fRMSDchiral for mathematical description of mutual position between stereoisomers
    Autorzy:
    Urniaz, Rafal Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/748148.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Matematyczne
    Tematy:
    fragment-level RMSD
    chiral recognition
    bioinformatics
    molecular modeling
    fragment-level RMSD, związki chiralne, stereoselektywność, bioinformatyka, modelowanie molekularne
    Opis:
    The ability of biological systems to recognize and distinguish between compounds is crucial for living systems. A detailed study of this mechanism seems to be an important supplement for analysis of possible contact interactions between compounds and environment. This process could be characterized by variety of descriptors respond to compounds’ structural and physicochemical properties. Usually, the measure of variation in molecule positions in the three dimensional space is realized by the Root Mean Square Deviation (RMSD) calculation. Here, the traditional concept of RMSD was readjusted as fragment-level RMSD (fRMSD) and applied for mathematical description of stereoisomers’ role in the chiral recognition process.
    Źródło:
    Mathematica Applicanda; 2015, 43, 1
    1730-2668
    2299-4009
    Pojawia się w:
    Mathematica Applicanda
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spektrometria mas w rozróżnianiu związków chiralnych
    Chiral recognition by mass spectrometry
    Autorzy:
    Drabik, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/172040.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    spektrometria mas
    rozróżnianie związków chiralnych
    związki chiralne
    oddziaływania typu gość-gospodarz
    metoda kinetyczna
    reakcje kompleksów jon–cząsteczka
    spektrometria ruchliwości jonów
    mass spectrometry
    chiral recognition
    kinetic method
    host–guest interaction
    ion-molecule reaction
    ion mobility spectrometry
    Opis:
    The phenomenon of optical activity was discovered by Louis Pasteur in 1848. Since this time, chirality of organic compounds observed in biological systems has became a central theme in scientific research. Synthesis and quantitation of enantiomerically pure compounds is important for a wide range of applications. Chirally pure compounds are required not only by pharmacology, but they are also of interest in cosmetic and food industry and many other applications. Similarity of enantiomers in their chemical and physical properties, except for optical rotation, makes their separation and detection very difficult. Until now, many methods have been used for the enantioselective discrimination of organic compounds, including nuclear magnetic resonance spectroscopy (NMR), circular dichroism (CD), capillary electrophoresis (CE) and chromatography (GC, HPLC), where an interference of a solvent cannot be excluded. Recent studies have shown that mass spectrometry (MS) is an alternative approach to traditional method for chiral recognition and determination of enantiomeric composition. Although, mass spectrometry has been considered as insensitive to chirality because enantiomers have the same mass and show identical mass spectra, it is now accepted as important tool for differentiating of enantiomeric compounds through their interactions with chiral reference molecules (Fig. 1). The ability to transfer diastereomeric non-covalent complexes between chiral selectors and analyte enantiomers, which differ in stability, into the gas-phase and measure such differences trough mass spectrometric ion abundances, has appeared with development of soft ionization techniques such electrospray ionization (ESI), fast atom bombardment (FAB) and matrix-assisted laser desorption/ionization (MALDI). Mass spectrometry-based methods for chiral recognition and quantitative determination of enantiomeric purity are attractive due to their speed, high sensitivity, low sample consumption, tolerance to impurities and ability to probe the analyte in a solvent free environment. Currently, there are four well-defined approaches for determining a measure of enantiomer discrimination, using either single-stage or tandem mass spectrometry. They can be classified into the following categories: (1) measurement of the relative abundance of diastereomeric complexes between chiral reference compound and the enantiomers (usually one isotopically labeled [10]), (2) enantioselective ion/molecule reaction between diastereomeric complexes and chiral or achiral reactants [11], (3) kinetic method [12] and (4) collision-induced dissociation (CID) of diastereomeric adducts in a tandem mass spectrometry (MS/MS) experiment [61, 62]. Over the past decade, new approaches to chiral separation and analysis of enantiomers have been introduced, where molecules are separated based on their mobility (ion mobility spectrometry) [66].
    Źródło:
    Wiadomości Chemiczne; 2011, 65, 7-8; 609-649
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies