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    Wyświetlanie 1-11 z 11
    Tytuł:
    Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae
    Autorzy:
    Zhang, Y.
    Yang, T.
    Huang, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087250.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    porcine contagious pleuropneumonia
    mice
    caspase-1 inhibitors
    caspase-1dependent pyroptosis
    Źródło:
    Polish Journal of Veterinary Sciences; 2020, 23, 4; 605-610
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The DFF40/CAD endonuclease and its role in apoptosis.
    Autorzy:
    Widłak, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1044225.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    caspase
    nuclease
    DNA fragmentation
    apoptosis
    Opis:
    The sequential generation of large-scale DNA fragments followed by internucleosomal chromatin fragmentation is a biochemical hallmark of apoptosis. One of the nucleases primarily responsible for genomic DNA fragmentation during apoptosis is called DNA Fragmentation Factor 40 (DFF40) or Caspase-activated DNase (CAD). DFF40/CAD is a magnesium-dependent endonuclease specific for double stranded DNA that generates double strand breaks with 3'-hydroxyl ends. DFF40/CAD is activated by caspase-3 that cuts the nuclease's inhibitor DFF45/ICAD. The nuclease preferentially attacks chromatin in the internucleosomal linker DNA. However, the nuclease hypersensitive sites can be detected and DFF40/CAD is potentially involved in large-scale DNA fragmentation as well. DFF40/CAD-mediated DNA fragmentation triggers chromatin condensation that is another hallmark of apoptosis.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 1037-1044
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE EFFECTS OF CARVACROL ON OXIDATIVE STRESS PARAMETERS AND APOPTOSIS PROCESS VIA TRPA1 CHANNELS IN NEUROBLASTOMA CELLS
    Autorzy:
    Gunal, Mehmet Y.
    Ovey, Ishak S.
    Powiązania:
    https://bibliotekanauki.pl/articles/895278.pdf
    Data publikacji:
    2019-06-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    apoptosis
    caspase-3
    ROS
    neuroblastoma
    carvacrol
    Opis:
    Objectives: This study is a preliminary study to investigate the effects of carvacrol (CRV) obtained from thyme on the apoptosis process in neuroblastoma cells. Methods: In this study, seven groups were designed as control, CRV, CRV + AP-18, CRV + melatonin, CRV + melatonin + AP-18, melatonin and melatonin + AP-18. All groups were stimulated using CNM (cinnamaldehyde) which is TRPA1 channel stimulator. Levels of Reactive oxygen species (ROS), caspase-3, caspase-9, mitochondrial depolarization, apoptosis, intracellular free calcium and 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) were measured. Data were evaluated using one way ANOVA analysis. Results: Levels of ROS, mitochondrial depolarisation, caspase-3 and -9 and apoptosis were significantly higher in all groups treated with CRV compared to control (P <0.05). On the other hand, in melatonin-treated group and melatonin + AP-18 treated group, ROS and caspase-3 were significantly lower than control (P <0,05). MTT levels were significantly decreased in all groups treated with CRV compared to control (P <0.05). On the other hand, in melatonin-treated group and melatonin + AP-18 treated group, MTT was higher than control(P <0,05). Conclusion: It has also been shown that CRV can also exert its effects through TRPA1 channels in neuroblastoma cells, which may accelerate the apoptosis process by acting on these channels, increasing ROS and caspase-3 levels. Changes in MTT levels support this result. However, in order to better evaluate the effects of CRV on the apoptosis process, it would be useful to investigate changes in caspase-9, mitochondrial depolarization, and calcium channels.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 535-542
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design, Synthesis and Biological Evaluation of Novel Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives as Potential Anticancer Agents
    Autorzy:
    Abdelazeem, Ahmed H.
    Gouda, Ahmed M.
    Omar, Hany A.
    Alrobaian, Majed
    Powiązania:
    https://bibliotekanauki.pl/articles/895393.pdf
    Data publikacji:
    2018-06-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    apoptosis
    anticancer
    S-benzothiazolotriazole
    Kinase
    caspase3/7
    Opis:
    In the present study, we have designed and synthesized a novel series of benzothiazolotriazole derivatives as potential anticancer agents. The anticancer activity of the newly synthesized compounds was evaluated against three cancerous cell lines; A549 (human lung adenocarcinoma), MCF-7 (human breast carcinoma) and Hep3B (human hepatocellular carcinoma) using MTT assay. Among this series, compounds 15 and 16 showed the most promising anticancer activity with IC50 values between 11.1 to 21.5 μM. Kinase profiling was performed for the most potent compounds 15 and 16 and it revealed weak inhibitory activity against 10 various kinases, where the highest inhibition was against CDK2/Cyclin A1 by compound 15. Furthermore, caspase-3/7 assay also indicated that the same compound 15 has the ability to induce apoptosis through the activation of effector caspase-3/7 family. Therefore, it could be deduced that the S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole is a promising novel anticancer scaffold with antiproliferative and apoptosis-inducing activities deserves to be taken up as a lead for further structural optimization.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Upregulation of GRP78 and caspase-12 in diastolic failing heart
    Autorzy:
    Sun, Yingying
    Liu, Guanghui
    Song, Tao
    Liu, Fang
    Kang, Weiqiang
    Zhang, Yun
    Ge, Zhiming
    Powiązania:
    https://bibliotekanauki.pl/articles/1040708.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    caspase-12
    diastolic heart failure
    GRP78; hypertension
    apoptosis
    Opis:
    Background: The endoplasmic reticulum (ER) fulfills multiple cellular functions. Various stimuli can potentially cause ER stress (ERS). ERS is one of the intrinsic apoptosis pathways and apoptosis plays a critical role in hypertension. Glucose regulated protein 78 (GRP78) has been widely used as a marker for ERS and caspase-12 mediated apoptosis was a specific apoptotic pathway of ER. The expression of GRP78 and caspase-12 remains poorly understood in the diastolic heart failure resulting from hypertension. Methods: We used spontaneously hypertensive rats (SHRs) to establish a model of diastolic heart failure, and performed immunohistochemistry, western blot, and real-time PCR to analyze GRP78 and caspase-12. Results: We found that GRP78 and caspase-12 had enhanced expression at protein and mRNA levels. Conclusions: These results suggest that GRP78 and caspase-12 were upregulated in cardiomyocytes and ERS can contribute to cardiac myocyte apoptosis in the diastolic heart failure resulting from hypertension.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 3; 511-516
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bioaccumulation of Chromium, Iron, and the Expression of TNF-α and Caspase-3 in Mudskipper (Periophthalmus spp.) from Ambon Island Waters, Indonesia
    Autorzy:
    Liline, Sintje
    Rumahlatu, Dominggus
    Salmanu, Sriyanti I. A.
    Pattipeilohy, Mery
    Sangur, Kristin
    Powiązania:
    https://bibliotekanauki.pl/articles/2173288.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Inżynierii Ekologicznej
    Tematy:
    heavy metals
    Cr
    Fe
    TNF-α
    caspase-3
    mudskipper
    Opis:
    TNF-α protein and caspase-3 in mudskipper muscle can be used as a biomarker to evaluate the environmental conditions. Therefore, this study aimed to analyze the heavy metal contents, specifically Cr and Fe, in the sediments from the mangrove area, as well as the expression of TNF-α and caspase-3 in mudskipper muscle. The samples used were the sediments and mudskippers from the waters of Poka, Waai, and Rutong Villages. The heavy metals were analyzed using Atomic Absorption Spectrophotometry (AAS), while the TNF-α and caspase-3 expressions were assessed with immunohistochemical staining. Observations were carried out using an optical microscope with 1000x magnification. The results showed that the proportion of Fe accumulated in mudskipper at the three locations was greater than Cr, while Cr was higher in the sediment compared to Fe. Moreover, the TNF-α and caspase-3 expressions appeared in muscle organs in varying amounts. This indicates that Cr and Fe under excessive conditions can be toxic to mudskipper causing muscle inflammation and cell death, which leads to the expression of TNF-α and caspase-3.
    Źródło:
    Journal of Ecological Engineering; 2022, 23, 7; 90--104
    2299-8993
    Pojawia się w:
    Journal of Ecological Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of L-carnitine on morphology and cellular parameters of hen erythrocytes
    Autorzy:
    Kasperek, K.
    Bownik, A.
    Knaga, S.
    Szabelak, A.
    Ślaska, B.
    Kwiecień, M.
    Jeżewska-Witkowska, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087630.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    L-carnitine
    erythrocyte morphology
    caspase 3/7
    hemolysis
    apoptosis
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 4; 811-813
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8
    Autorzy:
    Wang, Lu
    Pan, Xiao
    He, Liangqiang
    Zhang, Rong
    Chen, Wei
    Zhang, Jing
    Lu, Min
    Hua, Zi-Chun
    Powiązania:
    https://bibliotekanauki.pl/articles/1039602.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    caspase-8
    yeast two-hybrid
    Vps41
    protein interaction
    apoptosis
    Opis:
    Caspase-8 is a member of the cysteine-aspartic acid protease (caspase) family which plays a central role in apoptosis and development. We screened caspase-8 interacting proteins from mouse T-cell lymphoma and 7.5-day embryo cDNA libraries by yeast two-hybrid system and obtained eleven positive clones, including Vacuolar protein sorting 41 (Vps41), a protein involved in trafficking of proteins from the late Golgi to the vacuole. The interaction of Vps41 with caspase-8 was confirmed by co-immunoprecipitation (co-IP) and co-localization studies in HEK293T cells. Co-IP experiments also showed that Vps41 binds to the p18 subunit of caspase-8 through its WD40 region and RING-finger motif. Furthermore, we found that overexpression of Vps41 promotes Fas-induced apoptosis in A549 human lung adenocarcinoma cells. The cleavage of caspase-3, a caspase-8 downstream effector, was increased when cells were transfected with Vps41-overexpressing plasmid. Together, these results suggest a novel interaction of caspase-8 with Vps41 and provide a potential role of Vps41 beyond lysosomal trafficking.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 1; 37-42
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CD25 (IL-2R) expression correlates with the target cell induced cytotoxic activity and cytokine secretion in human natural killer cells
    Autorzy:
    Rudnicka, Karolina
    Matusiak, Agnieszka
    Chmiela, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038939.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    natural killer cells
    CD25
    cytotoxic activity
    granzyme
    caspase
    cytokines
    Opis:
    Cytotoxic activity is one of the major functions of Natural Killer (NK) cells and is a critical effector mechanism of innate immune responses against infected or cancer cells. A variety of assays have been developed to determine NK cell cytotoxic activity, however a receptor-based screening tool is still lacking. Here, we propose the CD25 receptor as a candidate for NK cell cytotoxicity marker. We have verified that there is a correlation between classic target cell induced cytotoxicity markers and the CD25 expression on NK cells. Non-adherent lymphocyte fractions pre-stimulated with Escherichia coli O55:B5 lipopolysaccharide were co-cultured with settled HeLa targets in a four hour long cytotoxic assay. The cytotoxic effect was evaluated by MTT reduction assay and quantification of soluble cytotoxicity markers (granzyme B, FasL, caspase-8, IFN-γ and IL-2) was done by ELISA. Lymphocytes were stained with anti-CD3-Cy-5, anti-CD56/CD16/Nkp46-FITC and anti-CD25-PE antibodies and analyzed by flow cytometry. We observed that the CD25 expression exclusively on the CD3-CD56+CD25+ NK cells was positively correlated with their cytotoxic function evaluated by the MTT test (r = 0.68), the upregulation of granzyme B (r = 0.89), IL-2 (r = 0.78) and IFN-γ (r = 0.57), however, it was not positively correlated with FasL and caspase-8. We conclude that the CD25 expression might serve as an in vitro receptor-based screening tool for NK cell activity.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 4; 885-894
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of luteinizing hormone regulation of maturation and apoptosis, expression of LHR and FSHR in cumulus-oocyte complexes in Lanzhou fat-tailed sheep
    Autorzy:
    Wei, S.C.
    Deng, Y.Y.
    Lai, L.J.
    Liang, H.Q.
    Lin, G.Z.
    Gong, Z.D.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087862.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    In vitro maturation
    apoptosis
    luteinizing hormone
    cumulus oocyte complexes
    Caspase-3
    receptor
    Źródło:
    Polish Journal of Veterinary Sciences; 2017, 4; 759-768
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of interleukin-4 in down-regulation of endothelin-1 during gastric ulcer healing: effect of sucralfate
    Autorzy:
    Slomiany, B.L.
    Piotrowski, J.
    Slomiany, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/70539.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    chronic ulcer
    gastric ulcer
    interleukin 4
    sucralfate
    ulcer healing
    tumour necrosis factor-alpha
    gastric mucosa
    endothelin-1
    caspase-3
    apoptosis
    rat
    Źródło:
    Journal of Physiology and Pharmacology; 2000, 51, 1
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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