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Wyszukujesz frazę "Preeclampsia" wg kryterium: Temat

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    Tytuł:
    Acetylsalicylic acid in prevention of preeclampsia
    Autorzy:
    Bałabuszek, Kamil
    Mroczek, Anna
    Pawlicka, Marta
    Radzka, Agnieszka
    Bednarski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1177738.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Preeclampsia
    acetylsalicylic acid
    pregnancy
    Opis:
    Preeclampsia is a frequent and dangerous complication of pregnancy. It is a significant cause of death for the mother and baby. In the course of this disease, the blood flow in the placenta is impaired, what leads to foetus hypoxia. It is characterized by high blood pressure and frequently large amount of protein in urine. To describe whether acetylsalicylic acid is effective in prevention of preeclampsia. Standard up-to-date criteria were followed for review of the literature data. A search for English-language articles in PubMed database was performed. Papers published in 2017 were reviewed. In double-blind trial published in 2017 in The New England Journal of Medicine researchers divided women who were at high risk for preeclampsia into two groups. One group was receiving acetylsalicylic acid and other was receiving placebo. Preeclampsia was observed in 1.6% participants in the acetylsalicylic acid group, compared with 4.3% in the placebo group. From other study we found out that acetylsalicylic acid has a dose-response effect. Greater reduction in the risk of preeclampsia was reported with the acetylsalicylic acid dosage >75 mg/d. When acetylsalicylic acid was included in treatment at >16 weeks, there was less reduction of preeclampsia without relationship with acetylsalicylic acid dosage. Other meta-analysis shows that there was no statistically significant difference in occurrence of preeclampsia between women who started taking acetylsalicylic acid before and after 16th week of pregnancy. Acetylsalicylic acid is a good agent to prevent of preeclampsia. It should be prescribed to women in high risk groups regardless of the duration of pregnancy even though it may not reduce the risk of preeclampsia as much as before 16th week of gestation.
    Źródło:
    World Scientific News; 2018, 101; 229-236
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Placental prostate-specific antigen content in preeclampsia
    Autorzy:
    Can, Murat
    Acıkgoz, Serefden
    Guven, Berrak
    Ozmen Bayar, Ulku
    Powiązania:
    https://bibliotekanauki.pl/articles/1039712.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    preeclampsia
    prostate specific antigen
    Opis:
    Preeclampsia is a multisystem disorder that can manifest clinically with hypertension and proteinuria. Previous studies reported the presence of placental PSA in normal pregnancy but no study has been done in preeclampsia. The aim of this study was to investigate PSA content in preeclampsia. Preeclampsia was diagnosed according to the American College of Obstetricians and Gynecologists criteria. Placentas were obtained from 33 preeclamptic and 34 normotensive women. Placenta samples were homogenized and the supernatants were immediately analyzed. The tissue PSA content was measured by Immulite 2000 PSA assay. The data were analyzed with Student's t-test and Pearson correlation test. There was a significant difference in placental PSA content between preeclamptic and normotensive women. Placental content of PSA was higher in the preeclamptic group with intrauterine growth restriction (IUGR) than in the preeclamptic and normotensive pregnant without IUGR groups. No significant difference was found in this respect between preeclamptic and normotensive women without IUGR. In conclusion, we found that placental PSA content is elevated in preeclampsia and negatively correlated with infant birth weight. Further studies will be necessary to define the roles of PSA more precisely and to examine its effects on the pathophysiology of preeclampsia.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 3; 367-369
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Predictive factors for preeclampsia in pregnant women: a unvariate and multivariate logistic regression analysis
    Autorzy:
    Direkvand-Moghadam, Ashraf
    Khosravi, Afra
    Sayehmiri, Kourosh
    Powiązania:
    https://bibliotekanauki.pl/articles/1039684.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    preeclampsia
    risk factors
    independent predictive factors
    Opis:
    Introduction: Several risk factors have been used to predict preeclampsia. The role of some risk factors as predictors associated with preeclampsia among Iranian women was analyzed in the present study using logistic regression. Materials and Methods: 610 women attending the obstetric ward of Mustafa hospital in Ilam were enrolled in this study. Demographic variables such as age, Body Mass Index (BMI), medical and obstetrics variables such as education, number of pregnancy, abortion and parity from May to September 2010 were analyzed. We used the unvaried and multiple logistic regression analyses to predict preeclampsia. Results: The history of preeclampsia, hypertension, and infertility showed to be good independent predicator variables for preeclampsia using multivariate logistic regression analysis (OR was 5.46, 2.34 and 3.07 respectively). Area Under the Receiver Operation Character (AUROC) was estimated to be 0.67 (95% CI 0.59-0.67, p<0.01) indicating the efficacy of the model for the prediction. Conclusion: The history of preeclampsia, hypertension and infertility predict preeclampsia with an increased odds ratio. Using such variables in regression analysis can help to diagnose preeclampsia beforehand and hence allow timely intervention.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 4; 673-677
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of biomarkers in early prediction and molecular mechanisms of preeclampsia
    Autorzy:
    Bhaskar Kalarani, Iyshwarya
    Veerabathiran, Ramakrishnan
    Mohammed, Vajagathali
    Powiązania:
    https://bibliotekanauki.pl/articles/25719434.pdf
    Data publikacji:
    2022-12-05
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    risk factors
    biomarkers
    preeclampsia
    angiogenic factors
    Opis:
    Preeclampsia (PE) is determined as high blood pressure during pregnancy and proteinuria of 300 mg or more in a 24-hour urine sample. PE is a leading cause of maternal death, with about 55000 deaths worldwide each year. Toxic substances that damage the maternal vascular endothelium induced PE, resulting in liver and kidney malfunction. It is crucial for obstetricians to identify as early as possible the patients who are at risk for PE. Familial history of PE, polycystic ovarian disease, sleeping disorders, urinary infections, periodontal disease, smoking, and lifestyle are the major risk factors involved in this disease. VEGF, sFlt1, sENG, PAPP-A, inhibin A and activin A proteins, fetal hemoglobin, heat shock protein and placental protein have been shown to predict or diagnose PE and help in understanding the pathogenesis of PE. In addition, a better understanding of PE pathogenesis would aid in identifying the most effective treatments that do not impair the fetus’ prognosis. The aim of our study is a review of the pathophysiology and biomarkers, such as pro- and anti-angiogenic substances, that may be useful in the detection of PE in the future.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2022, 5, 2; 57-66
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Electronegativity and intrinsic disorder of preeclampsia-related proteins
    Autorzy:
    Polanco, Carlos
    Castañón-González, Jorge
    Uversky, Vladimir
    Buhse, Thomas
    Samaniego Mendoza, José
    Calva, Juan
    Powiązania:
    https://bibliotekanauki.pl/articles/1038693.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    preeclampsia
    intrinsically disordered proteins
    structural proteomics
    bioinformatics
    antimicrobial peptides
    polarity index method
    lipoproteins
    angiogenesis proteins
    Opis:
    Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 99-111
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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