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Tytuł:
New directions in cervical cancer prophylaxis worldwide and in Poland - case study of the Polish rural female population
Autorzy:
Maździarz, Agnieszka
Wyględowski, Jerzy
Osuch, Beata
Jagielska, Beata
Śpiewankiewicz, Beata
Powiązania:
https://bibliotekanauki.pl/articles/990009.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
cervical cancer
prophylaxis
screening of cervical cancer
cytology
Opis:
Introduction. Cervical cancer is one of the most frequent malignant neoplasms in females. Such neoplasms can be almost completely eliminated by means of adequate primary and secondary prophylaxis. The most developed countries focus their attention on the improvement of prophylaxis systems, test quality, and efficacy improvement, as well as on the expansion of the primary prophylaxis. In Poland, the discussions focus on the improvement of the malfunctioning population programme. Objective. Drawing on recent research findings, the article presents current Polish and global recommendations with regard to screening tests for cervical cancer. The results of the Population Programme of Prophylaxis and Early Detection of Cervical Cancer are discussed in the context of current trends of healthy behaviour among women inhabiting rural areas. Description of the state of knowledge. In the future, it will be relevant to increase the number of human papillary virus (HPV) tests as part of the prophylaxis programme, especially among the high risk patient group. In particular, there is a necessity to increase the number of vaccinations among young women, especially before the beginning of their sexual activity, as well as to establish new strategies of secondary prophylaxis in this group. At present, women who had been vaccinated should undergo routine screening. In Poland, the report based on SIMP registry (IT System of Prophylaxis Monitoring), shows that only 27% of the 3.3 million of invited women participated in the cytology tests. The data analysis shows that women living in rural areas more often respond and participate in the tests, compared to women living in the cities (39.3% vs. 16.8%).
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of selected environmental factors on attendance in the Breast and Cervical Cancer Early Detection Programme in the Wielkopolska Province of Poland during 2007–2012
Autorzy:
Kycler, Witold
Kubiak, Anna
Rzymski, Paweł
Wilczak, Maciej
Trojanowski, Maciej
Roszak, Magdalena
Włoszczak-Szubzda, Anna
Rzymska, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/989556.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
screening
breast cancer
cervical cancer
Opis:
Breast and cervical cancer represent a significant health and economic issue for Polish society, although if detected early, both can be cured successfully. For this reason, since 2006, according to the National Cancer Combat Programme, populationbased screening programmes have been implemented, aimed at reducing the mortality and morbidity for breast and cervical cancer. The aim of this study is to determine which of the selected four environmental factors affect attendance for screening mammography and cytology. Analysis included data from questionnaires filled in during mammography by 582,959 women aged 50–69 years, and 288,142 women during cytology, aged 25–59 years, in 2007–2012 in the Wielkopolska Province of Poland. It was found that the impact of medical staff on the attendance for cytological screening was the strongest statistically significant factor (p = 0,0001). Invitation by name (p=0,001) and other factors (p= 0,0001) also affected the attendance. In the cytological screening, medical staff was the factor that had the greatest impact on attendance. Other factors, such as self-reporting, increased participation in the next screening rounds, although the factors that affect attendance changed over time. Their constant analysis is essential for the efficient and effective evaluation of screening programsme.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Youth and Cancer Prevention (with the Example of Cervical Cancer)
Autorzy:
Świątkiewicz-Mośny, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1997547.pdf
Data publikacji:
2017-12-31
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
youth
cancer prevention
cervical cancer
Opis:
The research results presented in this article originate from the research and educational project conducted from January to June 2017, titled Prevention of cervical carcinoma, or how it is done in Tychy. Analysis of knowledge sources and the views on HPV vaccines, which was funded with a grant by the Polish Cancer League Foundation. The research material allowed for formulating the guidelines for the educational and preventive treatment programs addressed to young people and their parents. Despite free vaccinations against the HPV virus from some local governments, the percentage of people covered by vaccinations is decreasing. What is needed in order to reverse the negative tendencies is a set of new, innovative solutions, addressed at the needs and expectations of the beneficiaries. Therefore, people should be educated on the risk of falling ill, while HPV vaccinations constitute an important element of primary prevention.
Źródło:
The New Educational Review; 2017, 50; 83-93
1732-6729
Pojawia się w:
The New Educational Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessing the knowledge of cervical cancer by women from Biala Podlaska, Lubelskie Voivodeship
Ocena wiedzy kobiet zamieszkałych w powiecie bialskim, województwo lubelskie, dotycząca raka szyjki macicy
Autorzy:
Gładysz, I.
Powiązania:
https://bibliotekanauki.pl/articles/2048844.pdf
Data publikacji:
2021
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
cervical cancer
knowledge
women
Opis:
Background. In the female population, cervical cancer is classified as one of the too late diagnosed cancers. Cervical cancer incidence and mortality rates in Poland are among the highest in the European Union. The aim of the paper is the assessment of women’s knowledge about cervical cancer based on the study of the feminine population in the county of Biała Podlaska. Material and methods. The study covered a group of 172 women living in the county of Biała Podlaska, Lubelskie Voivodeship, Poland. The research tool was an original questionnaire. The statistical analysis was performed using the STATISTICA v 10. program and the Pearson Chisquare test. Results. More than half of respondents (55.8%) indicated the following risk factors of cervical cancer: early onset of sexual life, many partners in a partner, infection of the cervix with HPV and herpes viruses, many deliveries, and smoking. The majority of respondents (62.2%) believe that cytology and gynecological examination are part of the preventive examination. Conclusions. 1. Respondents’ knowledge about the risk factors of cervical cancer is sufficient. 2. Respondents above 26 years of age possess knowledge about human papillomavirus (HPV) vaccination as a means of preventing cervical cancer. 3. Young women’s knowledge about HPV vaccination is insufficient.
Wprowadzenie. W populacji kobiet rak szyjki macicy zaliczany jest do nowotworów zbyt późno diagnozowanych. Wskaźniki zachorowalności oraz umieralności na raka szyjki macicy w Polsce należą do jednych z najwyższych w Unii Europejskiej. Celem pracy jest ocena wiedzy kobiet na temat profilaktyki raka szyjki macicy w oparciu o badania populacji kobiet zamieszkałych na terenie powiatu bialskiego. Materiał i metody. Badaniami objęto grupę 172 kobiet zamieszkałych na terenie powiatu bialskiego, województwo lubelskie, Polska. Narzędziem badawczym był autorski kwestionariusz ankiety. Analizę statystyczną wykonano w programie STATISTICA v 10. z wykorzystaniem testu Chi kwadrat Pearsona. Wyniki. Ponad połowa ankietowanych (55,8%) jako czynniki zwiększające ryzyko rozwoju raka szyjki macicy wskazała: wczesne rozpoczęcie życia płciowego, dużą liczbę partnerów lub partnerek u partnera, zakażenia szyjki macicy wirusem HPV i wirusem opryszczki, dużą liczbę porodów, palenie papierosów. Większość respondentek (62,2%) uważa, że cytologia i badanie ginekologiczne wchodzą w skład badań profilaktycznych. Wnioski. 1. Wiedza respondentek na temat czynników mających wpływ na rozwój raka szyjki macicy jest wystarczająca. 2. Respondentki w grupie wiekowej powyżej 26 lat posiadają wiedzę dotyczącą szczepień przeciwko HPV w prewencji raka szyjki macicy. 3. Wiedza kobiet młodych, dotycząca szczepień przeciwko HPV jest nie wystarczająca.
Źródło:
Health Problems of Civilization; 2021, 15, 1; 17-22
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of a midwife in cervical cancer prevention based on a study of the population of women residing in the Bialski poviat
Autorzy:
Gładysz, I.
Powiązania:
https://bibliotekanauki.pl/articles/2087959.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
cervical cancer
midwife
cancer prevention
Opis:
Background: Cancer, next to cardiovascular disease, obesity, diabetes, accidents, and mental illness, is one of the most common diseases of the 21st century. In the female population, cervical cancer is most often diagnosed at late stages. Aim of the study: The goal of the study is to determine the opinions of women who reside in Bialski poviat about midwife participation in cervical cancer screening and prevention. Material and methods: The study group was recruited from randomly selected patients from two physiotherapy offices in the Bialski poviat, as well as students and employees of the State University Pope John Paul II in Biala Podlaska. The research tool consisted of the author’s questionnaire concerning the role of midwives in cervical cancer prevention and consisted of 25 questions. Results: Almost half of the respondents or 44.2% (76) believe that the role of a midwife in cervical cancer prevention is based on health education given to women about cervical cancer screening and prevention. 27.3% (47) believe that the role of a midwife in prevention is based on the availability of cytological pap smears. Most or 56% (14) respondents from the age group over 55 and 29.2% (7) surveyed in the 18–25 age group knew about the important role of midwives performing cytological pap smear as part of a prevention strategy against cervical cancer. Conclusions: 1. The knowledge base of the women examined, regarding the role of a midwife in the prevention of cervical cancer, is lacking or insufficient. 2. The role of the midwife in the prevention of cervical cancer is unknown to young women in the 18–25 age group.
Źródło:
Medical Science Pulse; 2020, 14, 2; 44-48
2544-1558
2544-1620
Pojawia się w:
Medical Science Pulse
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
COMBINATION OF BERBERINE AND MATRINE AFFECTS APOPTOSIS AND CELLCYCLE IN HUMAN CERVICAL CANCER CELLS
Autorzy:
Zhang, Qijiayu
Sun, Yi
Huang, Yuxi
Sun, Jing
Zhao, Chongbo
Song, Yijun
Wu, Juanhua
Powiązania:
https://bibliotekanauki.pl/articles/895719.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
apoptosis
cervical cancer
Matrine
berberine
Opis:
Cervical cancer is the fourth leading cause of malignancy-related mortality in women worldwide, and effective advanced-stage therapies are urgently required. Berberine is a quaternary ammonium compound extracted from traditional Chinese medicinal herbs, including Phellodendron spp., with antibacterial and antitumor activities. Matrine, the main active ingredient of Sophora flavescens rhizomes, has not only traditionally described health effects but is also widely used for its anticancer, anti-inflammatory, immunoregulatory, antiviral, and hepatoprotective effects. We investigated the antitumor activities of berberine and matrine against human cervical cancer HeLa and SiHa cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, along with flow cytometry and western blotting analyses, to assess the effect of the compounds on the cellular status and apoptosis- and cell cycle-related proteins. The 24 h half-maximal inhibitory concentrations (IC50) of berberine and matrine were 123.633 ± 4.278 µmol/L and 9.625 ± 0.245 mmol/L against HeLa cells and 105.067 ± 3.745 µmol/L and 8.50 ± 0.23 mmol/L against SiHa cells, respectively. Berberine plus matrine inhibited cancer cell growth and caused cell cycle arrest. We observed an increased stimulation of apoptosis, which was likely mediated by enhanced levels of caspase-3, caspase-9, and B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), as well as decreased Bcl-2 protein expression. Cell cycle arrest in the G1 phase was probably mediated by p21 upregulation and cyclin-dependent kinase (Cdk)-4, Cdk-6, and cyclin D1 suppression. Combination treatment with berberine and matrine effectively inhibited human cervical cancer cell proliferation, most likely by stimulating apoptosis and inducing cell cycle arrest.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1089-1097
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the knowledge of the issues related to human papillomavirus infections within young women
Autorzy:
Węgorowski, Paweł
Michalik, Joanna
Turkowska, Karolina
Stanisławek, Andrzej
Wolski, Dariusz
Bieńko, Marek
Radzki, Radosław P.
Powiązania:
https://bibliotekanauki.pl/articles/454862.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
HPV virus
human papillomavirus cervical cancer
Opis:
Introduction. Human papillomavirus infections are frequent in on average 9% to 13% of the female population, and the risk of infection throughout life exceeds 50%. The HPV virus causes changes in the mucous membranes and the skin of the genital area in both women and men. Aim. This paper presents epidemiology, prophylaxis, diagnostics and treatment of HPV and cervical cancer infections. In addition, the knowledge of issues related to human papillomavirus infection among young women was assessed. Materials and methods. The diagnostic survey method was used to carry out the research. The research tool was a questionnaire of own authorship consisting of 41 questions. The research group consisted of 240 women. The research was carried out from June to September 2016 at the Chodźki Medical Center and the Luxmed facility in Lublin. Results. There is a relationship between the education of the respondents and their knowledge about the human papillomavirus infection. The studies did not show a significant relationship between the self-esteem of the studied women and whether they were vaccinated against the HPV virus (Chi-square = 0.362, p = 0.547). Conclusions. The general level of knowledge on issues related to human papillomavirus infection among young women is at the secondary level. A higher level of general knowledge was shown by women with better education, related to the medical and biological sciences. The self-assessment of the respondents coincides with the general knowledge, based on detailed questions, on issues related to HPV infection. Promoting knowledge about HPV infection is unsatisfactory
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 308-316
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Haemocytometric profile and plasma levels of selected cytokines in patients at various stages of cervical cancer
Autorzy:
Alani Jimoh, Mutiu
Adekunle Onifade, Abdulfatah
Mpakaboari Abbiyesuku, Fayeofori
Fabian Edem, Victory
Kadiri Rahamon, Sheu
Ganiyu Arinola, Olatunbosun
Powiązania:
https://bibliotekanauki.pl/articles/29520454.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cancer stage
cervical cancer
haemocytometry
interleukin-6
parity
Opis:
Introduction and aim. Reports have shown that there is alteration in haematological and inflammatory processes in patients with cervical cancer. However, there is the dearth of information on the pattern of alteration in Nigerian patients with cervical cancer at various stages of the disease. Therefore, haemocytometric profile and plasma levels of interleukin-6 (IL-6) and IL-12 were determined in Nigerian patients with cervical cancer at various stages of the disease. Material and methods. Eighty-nine adults consisting of 49 patients with cervical cancer and 40 apparently healthy controls were enrolled into this study. Haemocytometric profile was determined using automated haematology analyzer while the plasma levels of interleukin-6 (IL-6) and IL-12 were determined using ELISA. Results. Of the participants with cervical cancer, 6.12%, 24.49%, 53.06% and 16.33% were in stages I, II, III and IV respectively. The mean plasma IL-6 level was significantly higher in patients at stage IV of the cancer compared with those in stages I, II and III. No significant differences were observed in the mean plasma IL-12 level, and the haemocytometric profile when patients in different stages of the cancer were compared with one another. Plasma IL-6 had significant positive correlation with the lymphocytes count and cancer stage but had significant negative correlation with packed cell volume (PCV), haemoglobin and total white blood cells count (WBC) in patients with cervical cancer. Conclusion. Interleukin-6 appears to play an important role in the progression of cervical cancer and could be involved in cervical cancer-associated alteration in haemocytometric profile.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 696-703
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spectacular efficacy of neoadjuvant chemotherapy in a patient with cervical cancer of IB2 grade according to FIGO 2009
Spektakularna skuteczność chemioterapii neoadiuwantowej u pacjentki z rozpoznaniem raka szyjki macicy w stopniu IB2 według FIGO 2009 r.
Autorzy:
Kaźmierczak, Kamila
Nowakowski, Błażej
Kufel-Grabowska, Joanna
Cholewiński, Witold
Powiązania:
https://bibliotekanauki.pl/articles/1035650.pdf
Data publikacji:
2020
Wydawca:
Medical Education
Tematy:
cervical cancer
neoadjuvant chemotherapy
positron emission tomography
Opis:
The presented case report is an example of a spectacular effect of induction systemic treatment in a patient with locally advanced cervical cancer of IB2 grade according to FIGO 2009 (International Federation of Gynecologist and Obstetrician). The effect of induction chemotherapy (three series in paclitaxel/24 h + cisplatin regimen at an interval of three weeks) was the total metabolic response of the primary tumor and nodal lesions found in FDG-PET/CT (18F-fluorodeoxyglucose – positron emission tomography combined with computed tomography) as well as an image of total regression of the tumor in the obtained postoperative histopathological examination.
Przedstawiony opis przypadku jest przykładem spektakularnego efektu zastosowania chemioterapii neoadiuwantowej (NACT, neoadjuvant chemotherapy) u pacjentki z miejscowo zaawansowanym rakiem szyjki macicy w stopniu IB2 według FIGO 2009 r. (International Federation of Gynecologist and Obstetrician). Efektem zastosowanej chemioterapii indukcyjnej (trzech serii w schemacie paklitaksel/24 h + cisplatyna w odstępie 3-tygodniowym) była całkowita odpowiedź metaboliczna guza pierwotnego i zmian węzłowych stwierdzona w badaniu FDG-PET/CT (18F-fluorodeoksyglukoza – pozytonowa tomografia emisyjna połączona z tomografią komputerową), a także obraz całkowitej odpowiedzi patologicznej w otrzymanym pooperacyjnym badaniu histopatologicznym.
Źródło:
OncoReview; 2020, 10, 2; 69-76
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Frequency and pattern of gynecologic cancers from 2010 to 2014 in Beira, Mozambique
Częstość występowania i profil nowotworów kobiecych narządów płciowych w latach 2010–2014 w mieście Beira w Mozambiku
Autorzy:
Ferro, Josefo
Schiavone, Marcella
Di Gennaro, Francesco
Putoto, Giovanni
Bertoldo, Alessandro
Pizzol, Damiano
Powiązania:
https://bibliotekanauki.pl/articles/1029688.pdf
Data publikacji:
2017
Wydawca:
Medical Communications
Tematy:
cervical cancer
epidemiology
gynecologic cancers
low-income countries
Opis:
Objective: Gynecologic cancers represent a large health, social and economic burden worldwide. In low-income countries, particularly in Mozambique, little data is available and no effective policies are implemented to fight these diseases. Our objective was to trace the epidemiological profile of gynecologic cancers from 2010 to 2014 in Beira, Mozambique. Methods: We retrospectively reviewed the registers of the Department of Pathology of Central Hospital of Beira to identify all cases of gynecologic malignancies recorded from January 2010 to December 2014. Results: Most of the diagnosed female cancers (43.4%) were gynecologic and, among these, cervical cancer was definitely the most commonly reported cancer every year, ranging from 86.7% in 2013 to 93.3% in 2014. Conclusion: As in many low-income countries, the access to screening programs for gynecologic cancer is not effective in Mozambique; therefore urgent preventive policies are crucial to address this emergent issue.
Cel: Nowotwory kobiecych narządów płciowych stanowią istotne obciążenie zdrowotne, społeczne i ekonomiczne na całym świecie. W krajach o niskich dochodach, w szczególności w Mozambiku, brak jest zarówno dostępnych danych, jak i skutecznych strategii walki z tymi chorobami. Celem badania było prześledzenie profilu epidemiologicznego nowotworów ginekologicznych w latach 2010–2014 w mieście Beira w Mozambiku. Metoda: Autorzy dokonali retrospektywnego przeglądu rejestrów medycznych Oddziału Patologii Szpitala Centralnego w Beirze w celu wyodrębnienia wszystkich przypadków nowotworów kobiecych narządów płciowych odnotowanych w okresie od stycznia 2010 do grudnia 2014 roku. Wyniki: W większości przypadków (43,4%) rozpoznane u kobiet nowotwory dotyczyły narządów rodnych, przy czym rak szyjki macicy był zdecydowanie najczęściej odnotowywanym nowotworem w  każdym roku (od 86,7% w  2013 do 93,3% w 2014 roku). Wniosek: Podobnie jak w wielu krajach o niskich dochodach, również w Mozambiku dostęp do programów przesiewowych nowotworów narządów rodnych jest ograniczony – niezbędne jest pilne podjęcie działań prewencyjnych.
Źródło:
Current Gynecologic Oncology; 2017, 15, 3; 189-193
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Place of residence does not significantly influence radiological morphology of cervical cancer
Autorzy:
Burdan, Franciszek
Mocarska, Agnieszka
Klepacz, Robert
Walocha, Jerzy
Kubiatowski, Tomasz
Surdyka, Dariusz
Kieszko, Dariusz
Patyra, Krzysztof
Żelazowska-Cieślińska, Iwonna
Starosławska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/989572.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
cervical cancer
rural-urban differences
magnetic resonance
oncology
Opis:
Introduction and objective. Cervical squamous cell carcinoma is one of the most common malignancies of women. Its incidence and morphology was analyzed based on the magnetic resonance (MR) data among rural and urban residents. Materials and method. The study involved 61 Caucasian women (58.26±9.63 years) preliminary diagnosed with a cervical cancer without any previous treatment. Standard MR examination, including diffusion weighted imagining, apparent diffusion coefficient (ADC) value measurement and dynamic contrast enhancement, was performed. Results. The rural residents (n=22) were insignificantly older. Their first and last menstruation were observed later and number of pregnancy was higher than in urban women (n=39). However, the incidence of miscarriage was insignificantly rarer. All the tumour linear diameters as well as its volume were insignificantly higher in rural women. The ADC value of the cervical tumor was insignificantly lower, while ADC of lymphatic nodules was higher in rural women. Insignificant changes in tumour grade between both examined groups were found in histological, clinical and radiological examinations. Place of residence did not influence any clinical symptoms nor tumour volume and its ADC. Colporrhoea and colpodynia were insignificantly more often observed in urban women, while parametrium, urinary bladder and rectal infiltrations were more commonly seen in rural residents. Higher risk of lymphatic spread to the internal iliac and parametral lymphatic nodes was reported in the rural community. Conclusion. Cervical cancer had similar morphology and growth pattern, regardless of the place of residence. However, a insignificantly larger tumour size among rural residents may suggest a higher incidence of lymphatic spread, probably as a result of less aaccess to modern health care.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An overview of Human Papilloma Virus
Autorzy:
Amarakoon, A. A. D. Gayathri Upeksha
Daulagala, S. W. P. L.
Fathima, Fara
Powiązania:
https://bibliotekanauki.pl/articles/1182889.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Papilloma virus; cervical cancer; RNA genome; control region
Opis:
Cervical cancer is the second commonest cause of cancer among women. According to the World Health Organization (WHO) data, in 2006 there were 1.4 million women who were suffering from cervical cancer and 80% of deaths among them were of women from developing countries. Genital infection with Human Papilloma Virus (HPV) is one of the major etiological factors for developing cervical cancers in almost all countries (World Health Organization, 2005). Papilloma viruses were first identified, cloned and sequenced from cervical tumor specimens and were subsequently established as important causative agents for the development of cervical cancer. Differences in prevalence rates are observed worldwide. Infection is more common in sexually active young women of 18-30 years and a reduction in acquisition of infection is observed after 30 years. The situation of Cervical cancer in Sri Lanka is identified as the second most common cancer among women in Sri Lanka and approximately 7.74 million women are included in the risk category. It is reported that nearly 850 die from cervical cancer each year.
Źródło:
World Scientific News; 2016, 53, 3; 275-308
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnostyka i leczenie neuroendokrynnych raków szyjki macicy - doświadczenia własne i przegląd piśmiennictwa
Diagnosis and treatment of neuroendocrine cervical cancer – own experience and review of literature
Autorzy:
Bidziński, Mariusz
Nasierowska-Guttmejer, Anna
Ćwikła, Jarosław
Bakuła-Zalewska, Elwira
Dańska-Bidzińska, Anna
Panek, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/908326.pdf
Data publikacji:
2007
Wydawca:
Medical Communications
Tematy:
chromogranin A
neuroendocrine cervical cancer
somatostatin analogs
synaptophysin
Opis:
Aim of paper: Neuroendocrine cervical cancer is a significant diagnostic and therapeutic challenge. For many years, these neoplasms were not differentiated from small-cell cancer. It was known, that these cancers were associated with poor prognosis and, in spite of combination of several therapeutic modalities, treatment outcome was far below expectations. Material and methods: Based on retrospective analysis and using synaptophysin and chromogranin A staining and assessment of cellular proliferative activity using MIB1 antibodies, out of 14 small-cell cancers 5 cases were selected, which fulfilled the criteria for neuroendocrine neoplasms and clinical course of the patients affected was analyzed. Results: In all cases, the disease has been diagnosed in FIGO stage I. Treatment consisted in extended hysterectomy m. Wertheim-Meigs and adjuvant radiochemotherapy. In two patients (40%), treatment failure was observed after a relatively short follow-up (within less than 16 months). One patient died due to liver metastases and in the other, faced with failure of chemotherapy, we instituted somatostatin receptor treatment. Conclusion: Immature or small-cell cervical cancer requires differentiation with neuroendocrine cancer and confirmation of its true nature by immunohistochemical studies. Therapy should encompass modern chemotherapy protocols and (in selected cases) isotope therapy using radio-labeled somatostatin analogs. Somatostatin analog therapy is reserved for patients featuring expression of somatostatin receptor on the surface of cancer cells.
Cel badania: Neuroendokrynne raki szyjki macicy stanowią bardzo poważne wyzwanie zarówno terapeutyczne, jak i diagnostyczne. Przez wiele lat nie odróżniano tych nowotworów od raków drobnokomórkowych. Wiadomym było, że raki te gorzej rokują, a terapia, pomimo kojarzenia szeregu metod leczniczych, w efekcie nie przynosiła zamierzonego skutku. Materiał i metody: Spośród 14 raków drobnokomórkowych w wyniku retrospektywnej analizy z zastosowaniem barwień na synaptofizynę i chromograninę A oraz oceny aktywności proliferacyjnej komórek przy zastosowaniu przeciwciała MIB1 wybrano 5 guzów, które spełniały kryteria nowotworów neuroendokrynnych, i przeanalizowano przebieg kliniczny u tych chorych. Wyniki: Wszystkie pacjentki miały rozpoznaną chorobę w I stopniu zaawansowania klinicznego wg FIGO. Leczenie polegało na rozszerzonym usunięciu macicy sposobem Wertheima-Meigsa oraz zastosowaniu uzupełniającej radio-chemioterapii. U 2 chorych (40%) w krótkim okresie - do 16 miesięcy po leczeniu pierwotnym stwierdzono niepowodzenie leczenia. Jedna pacjentka zmarła z powodu przerzutów do wątroby, zaś u drugiej po nieskutecznej chemioterapii wdrożono leczenie z zastosowaniem receptorów somatostatyny. Wnioski: Niskodoj-rzałe lub drobnokomórkowe raki szyjki macicy wymagają diagnostyki w kierunku raka neuroendotoynnego i potwierdzenia tego faktu badaniami immunohistochemicznymi. W leczeniu tych nowotworów należy wykorzystywać zarówno nowoczesne techniki chemioterapii, jak i (w wybranych przypadkach) terapię izotopową znakowanymi analogami somatostatyny. Leczenie analogami somatostatyny jest zarezerwowane dla tych chorych, u których stwierdza się ekspresję receptora somatostatynowego na powierzchni komórek raka.
Źródło:
Ginekologia Onkologiczna; 2007, 5, 1; 6-14
1731-5379
Pojawia się w:
Ginekologia Onkologiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High-risk HPV test in cervical cancer prevention - present and future
Autorzy:
Zarankiewicz, N.
Zielinska, M.
Kosz, K.
Kuchnicka, A.
Cisel, B.
Powiązania:
https://bibliotekanauki.pl/articles/2097691.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
cervical cancer
cervical screening
HPV primmary screening
hrHPV test
HPV DNA
Opis:
Introduction. Cervical cancer is the fourth most common cancer among women. It is related to persistent HPV infection. In order to improve diagnostic methods, a lot of research has been focused on detecting HPV DNA. A test known as a high- risk HPV test or HPV primary screening provides very encouraging results. Objective.The aim of this review is to present the actual knowledge about the possibilities of cervical cancer screening methods. Particular attention is paid to the question concerning the effectiveness of detecting viral DNA as a screening programme, compared to pap smear. State of knowledge. The HPV primary screening has higher sensitivity than the cervical smear test and it is able to detect lower-stage lesions, which are considered clinically irrelevant. Nonetheless, many HPV infections recede naturally. Therefore, relying only on the results of this test may expose women to unnecessary colposcopies and stress. Due to this fact, women under 30 years should not be screened with the hrHPV test. In view of its limitations, the HPV primary screening strategy is still tested worldwide as a pilot project. In Poland in 2019, a pilot project with the hrHPV test started at the National Institute of Oncology. Conclusions. Detecting viral DNA has its advantages and disadvantages. Further research is still required, but the hrHPV test has a great opportunity to become one of the main screening programmes worldwide, or at least, a valuable addition to cervical smear test.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2020, 14, 3
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The prognostic significance of histology and treatment modality in stage IB1 squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the uterine cervix: SEER study 2004–2008
Znaczenie prognostyczne histologii guza i metody leczenia w przypadku raka płaskonabłonkowego, gruczolakoraka i raka gruczołowo-płaskonabłonkowego szyjki macicy w stadium IB1: badanie zapisów z rejestru SEER dotyczących lat 2004–2008
Autorzy:
Herskovic, Alex
Yan, Weisi
Christos, Paul
Ye, Jason C.
Nori, Dattatreyudu
Ravi, Akkamma
Powiązania:
https://bibliotekanauki.pl/articles/1030122.pdf
Data publikacji:
2016
Wydawca:
Medical Communications
Tematy:
cervical cancer
radiation
surgery
radioterapia
rak szyjki macicy
operacja
Opis:
Objective: To determine the significance of histology and treatment modality on overall survival and cause-specific survival in stage IB1 cervical carcinoma. Methods: Cases of stage IB1 squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the uterine cervix managed with either radical hysterectomy, definitive radiation therapy which may include external beam radiation therapy and/or vaginal brachytherapy, or total abdominal hysterectomy with adjuvant radiation therapy which may include external beam radiation therapy plus/minus vaginal brachytherapy were abstracted from the SEER database (2004–2008). Cause-specific survival was calculated using Kaplan–Meier, log-rank, and multivariable Cox regression analyses. Results: Five-year cause-specific survival for squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma were 94.4%, 97.3%, and 85.7%, respectively (p = 0.001 by log-rank test). On multivariable Cox regression analysis, patients with squamous cell carcinoma were not more likely to die of cervical cancer than patients with adenocarcinoma (hazard ratio = 1.12, 95% confidence interval = 0.53–2.39); but patients with adenosquamous cell carcinoma were more likely to die of cervical cancer than patients with adenocarcinoma (hazard ratio = 3.65, 95% confidence interval = 1.41–9.44). Five-year cause-specific survival was 96.9%, 80.0%, and 92.4% for patients receiving radical hysterectomy, definitive radiation therapy, and total abdominal hysterectomy plus radiation therapy, respectively (p < 0.0001 by log-rank test). On multivariable Cox regression analysis, patients who received definitive radiation therapy and patients who received total abdominal hysterectomy plus radiation therapy were more likely to die of cervical cancer than patients who received radical hysterectomy. Conclusion: In patients with stage IB1 cervical cancer, on multivariable Cox regression analysis, patients with squamous cell carcinoma were not more likely to die of cervical cancer than patients with adenocarcinoma; patients with adenosquamous cell carcinoma were more likely to die of cervical cancer than patients with adenocarcinoma. Patients who received either definitive radiation therapy or total abdominal hysterectomy plus radiation therapy were more likely to die of cervical cancer than patients who received radical hysterectomy.
Cel pracy: Określenie wpływu histologii nowotworu oraz metody leczenia na całkowity czas przeżycia i czas przeżycia swoistego w przypadku raka szyjki macicy w stadium IB1. Metody: Analizowano zawarte w rejestrze SEER, obejmujące lata 2004–2008, przypadki raka płaskonabłonkowego, gruczolakoraka i raka gruczołowo-płaskonabłonkowego szyjki macicy w stadium IB1, w których zastosowano radykalną histerektomię, radykalną radioterapię, w tym napromienianie wiązką zewnętrzną i/lub brachyterapię dopochwową, bądź całkowitą histerektomię brzuszną z radioterapią adiuwantową, w tym napromienianie wiązką zewnętrzną z brachyterapią dopochwową lub bez niej. Czas przeżycia swoistego obliczono, wykorzystując analizę Kaplana–Meiera, test log-rank oraz wieloczynnikową analizę regresji Coxa. Wyniki: Pięcioletnie przeżycie swoiste w przypadku raka płaskonabłonkowego, gruczolakoraka oraz raka gruczołowo-płaskonabłonkowego wynosiło odpowiednio 94,4%, 97,3% i 85,7% (p = 0,001 wg testu log-rank). Wieloczynnikowa analiza regresji Coxa wykazała, że prawdopodobieństwo zgonu z powodu raka szyjki macicy u pacjentek z rakiem płaskonabłonkowym nie było wyższe niż u pacjentek z gruczolakorakiem (współczynnik ryzyka = 1,12; przedział ufności 95% = 0,53–2,39). Z kolei u pacjentek z rakiem gruczołowo-płaskonabłonkowym prawdopodobieństwo zgonu z powodu tego nowotworu było wyższe niż u pacjentek z gruczolakorakiem (współczynnik ryzyka = 3,65, przedział ufności 95% = 1,41–9,44). Pięcioletnie przeżycie swoiste wynosiło 96,9%, 80,0% i 92,4% u chorych, które zostały poddane odpowiednio radykalnej histerektomii, radykalnej radioterapii oraz całkowitej histerektomii brzusznej z radioterapią (p < 0,0001 wg testu log-rank). Wieloczynnikowa analiza regresji Coxa wykazała większe prawdopodobieństwo zgonu z powodu raka szyjki macicy u pacjentek, które zostały poddane radykalnej radioterapii, oraz tych, które przeszły zabieg całkowitej histerektomii brzusznej z radioterapią, w porównaniu z chorymi, które poddano radykalnej histerektomii. Wniosek: U chorych na raka szyjki macicy w stadium IB1 wieloczynnikowa analiza regresji Coxa wykazała, że prawdopodobieństwo zgonu z powodu raka szyjki macicy u pacjentek z rakiem płaskonabłonkowym nie było większe niż u pacjentek z gruczolakorakiem, z kolei u chorych z rakiem gruczołowopłaskonabłonkowym było wyższe niż u pacjentek z gruczolakorakiem. U pacjentek, które zostały poddane radykalnej radioterapii lub przeszły zabieg całkowitej histerektomii brzusznej z radioterapią, prawdopodobieństwo zgonu z powodu raka szyjki macicy było większe niż u chorych, które poddano radykalnej histerektomii.
Źródło:
Current Gynecologic Oncology; 2016, 14, 2; 78-84
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
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