Temat: 8-oxoguanine - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Cellular level of 8-oxo-2-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base/nucleoside.
Autorzy:: Foksinski, Marek
Gackowski, Daniel
Rozalski, Rafał
Olinski, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1043637.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: 8-oxoguanine
oxidative DNA damage
8-oxo-2'-deoxyguanosine
Opis:: We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base analysed with a recently developed methodology involving HPLC prepurification followed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are discussed.
Źródło:: Acta Biochimica Polonica; 2003, 50, 2; 549-553
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Impact of the Ser326Cys polymorphism of the OGG1 gene on the level of oxidative DNA damage in patients with colorectal cancer
Autorzy:: Kabzinski, Jacek
Walczak, Anna
Dziki, Adam
Mik, Michał
Majsterek, Ireneusz
Powiązania:: https://bibliotekanauki.pl/articles/1392877.pdf
Data publikacji:: 2018
Wydawca:: Index Copernicus International
Tematy:: colorectal cancer
OGG1
8-oxoguanine
DNA repair
oxidative damage
Opis:: As a result of reactive oxygen species operation, cell damage occurs in both cellular organelles and molecules, including DNA. Oxidative damage within the genetic material can lead to accumulation of mutations and consequently to cancer transformation. OGG1 glycosylase, a component of the Base Excision Repair (BER) system, is one of the enzymes that prevents excessive accumulation of 8-oxoguanine (8-oxG), the most common compound formed by oxidative DNA damage. In case of structural changes of OGG1 resulting from polymorphic variants, we can observe a significant increase in the concentration of 8-oxG. Linking individual polymorphisms to DNA repair systems with increased risk of colorectal cancer will allow patients to be classified as high risk and included in a prophylactic program. The aim of the study was to determine the level of oxidative DNA damage and to analyze the distribution of Ser326Cys polymorphism of the OGG1 gene in a group of patients with colorectal cancer and in a control group in the Polish population. Material and methodology. DNA was isolated from the blood of 174 patients with colorectal cancer. The control group consisted of 176 healthy individuals. The level of oxidative damage was determined by analyzing the amount of 8-oxguanine using the HT 8-oxo-dG ELISA II Kit. Genotyping was performed via the TaqMan method. Results. The obtained results indicate that Ser326Cys polymorphism of the OGG1 gene increases the risk of RJG and is associated with significantly increased levels of 8-oxoguanine. Conclusions. Based on the results obtained, we conclude that Ser326Cys polymorphism of the OGG1 gene may modulate the risk of colorectal cancer by increasing the level of oxidative DNA damage.
Źródło:: Polish Journal of Surgery; 2018, 90, 2; 13-15
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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