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Tytuł:
Decompositions of multigraphs into parts with two edges
Autorzy:
Ivančo, Jaroslav
Meszka, Mariusz
Skupień, Zdzisław
Powiązania:
https://bibliotekanauki.pl/articles/743551.pdf
Data publikacji:
2002
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
edge decomposition
multigraph
line graph
1-factor
Opis:
Given a family of multigraphs without isolated vertices, a multigraph M is called -decomposable if M is an edge disjoint union of multigraphs each of which is isomorphic to a member of . We present necessary and sufficient conditions for the existence of such decompositions if comprises two multigraphs from the set consisting of a 2-cycle, a 2-matching and a path with two edges.
Źródło:
Discussiones Mathematicae Graph Theory; 2002, 22, 1; 113-121
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Symmetric Hamilton Cycle Decompositions of Complete Multigraphs
Autorzy:
Chitra, V.
Muthusamy, A.
Powiązania:
https://bibliotekanauki.pl/articles/29788703.pdf
Data publikacji:
2013-09-01
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
complete multigraph
1-factor
symmetric Hamilton cycle
decomposition
Opis:
Let $n ≥ 3$ and $⋋ ≥ 1$ be integers. Let $⋋K_n$ denote the complete multigraph with edge-multiplicity $⋋$. In this paper, we show that there exists a symmetric Hamilton cycle decomposition of $⋋K_{2m}$ for all even $⋋ ≥ 2$ and $m ≥ 2$. Also we show that there exists a symmetric Hamilton cycle decomposition of $⋋K_{2m} − F$ for all odd $⋋ ≥ 3$ and $m ≥ 2$. In fact, our results together with the earlier results (by Walecki and Brualdi and Schroeder) completely settle the existence of symmetric Hamilton cycle decomposition of $⋋K_n$ (respectively, $⋋K_n − F$, where $F$ is a 1-factor of $⋋K_n$) which exist if and only if $⋋(n − 1)$ is even (respectively, $⋋(n − 1)$ is odd), except the non-existence cases n ≡ 0 or 6 (mod 8) when ⋋ = 1
Źródło:
Discussiones Mathematicae Graph Theory; 2013, 33, 4; 695-707
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On Ramsey $(K_{1,2}, Kₙ)$-minimal graphs
Autorzy:
Hałuszczak, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/743336.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
Ramsey minimal graph
edge coloring
1-factor
complete graph
Opis:
Let F be a graph and let , denote nonempty families of graphs. We write F → (,) if in any 2-coloring of edges of F with red and blue, there is a red subgraph isomorphic to some graph from G or a blue subgraph isomorphic to some graph from H. The graph F without isolated vertices is said to be a (,)-minimal graph if F → (,) and F - e not → (,) for every e ∈ E(F).
We present a technique which allows to generate infinite family of (,)-minimal graphs if we know some special graphs. In particular, we show how to receive infinite family of $(K_{1,2}, Kₙ)$-minimal graphs, for every n ≥ 3.
Źródło:
Discussiones Mathematicae Graph Theory; 2012, 32, 2; 331-339
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lower Bound on the Number of Hamiltonian Cycles of Generalized Petersen Graphs
Autorzy:
Lu, Weihua
Yang, Chao
Ren, Han
Powiązania:
https://bibliotekanauki.pl/articles/32083755.pdf
Data publikacji:
2020-02-01
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
generalized Petersen graph
Hamiltonian cycle
partition number
1-factor
Opis:
In this paper, we investigate the number of Hamiltonian cycles of a generalized Petersen graph $ P(N, k) $ and prove that $ \Psi(P(N,3)) \ge N \cdot \alpha_N $, where $ \Psi (P(N, 3)) $ is the number of Hamiltonian cycles of $P(N, 3)$ and $ \alpha_N $ satisfies that for any $ \epsilon > 0 $, there exists a positive integer $M$ such that when $ N > M $, $ ((1− \epsilon ) \frac{ (1−r^3) }{6r^3+5r^2+3) }( 1/r )^{N+2} < \alpha_N < ( (1+ɛ) \frac{ (1−r^3) }{6r^3+5r^2+3) }( 1/r )^{N+2} $, where $ 1/r = \text{max} \{ | \frac{1}{r_j} | : j=1,2,…,6 \} $, and each $ r_j $ is a root of equation $ x^6 + x^5 + x^3 − 1 = 0 $, $ r \approx 0.782 $. This shows that $ \Psi (P (N, 3) $ is exponential in $N$ and also deduces that the number of 1-factors of $ P(N, 3)$ is exponential in $N$.
Źródło:
Discussiones Mathematicae Graph Theory; 2020, 40, 1; 297-305
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
1-factors and characterization of reducible faces of plane elementary bipartite graphs
Autorzy:
Taranenko, Andrej
Vesel, Aleksander
Powiązania:
https://bibliotekanauki.pl/articles/743201.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
plane elementary bipartite graph
reducible face
perfect matching
1-factor
benzenoid graph
Opis:
As a general case of molecular graphs of benzenoid hydrocarbons, we study plane bipartite graphs with Kekulé structures (1-factors). A bipartite graph G is called elementary if G is connected and every edge belongs to a 1-factor of G. Some properties of the minimal and the maximal 1-factor of a plane elementary graph are given.
A peripheral face f of a plane elementary graph is reducible, if the removal of the internal vertices and edges of the path that is the intersection of f and the outer cycle of G results in an elementary graph. We characterize the reducible faces of a plane elementary bipartite graph. This result generalizes the characterization of reducible faces of an elementary benzenoid graph.
Źródło:
Discussiones Mathematicae Graph Theory; 2012, 32, 2; 289-297
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of oligochitosans in akt kinase regulation
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Kucharska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1034912.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Akt kinase – PKB
EAT cells proliferation
HIF-1 factor.
M2 pyruvate kinase
Opis:
Among characteristic properties of cancers, there is their increased glycolytic activity.Contrary to normal cells, neoplastic cells use anaerobic glycolysis, even when a sufficient amount of oxygen is available. The intensity of the process is associated with a considerable demand for energy in the form of ATP. Akt, which - acting through the mTOR pathway - activates the HIF-1 factor, which in turn activates hexokinase that participates in glucose phosphorylation, stimulates the transport of glucose to cells via increasing glucose transporters (GLUT) and activates lactate dehydrogenase (which transforms pyruvate to lactate). Chitosan, as well as products of its degradation - oligochitosans - contribute to inhibiting the activity of the Akt kinase, and thus contribute to inhibiting excessive glycolytic activity of Ehrlich ascites tumor (EAT) cells and to decreasing proliferation of these cells.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 73-81
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of adenoidectomy of serum insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children with otitis media with effusion
Autorzy:
Żelazowska-Rutkowska, Beata
Jacewicz, Klaudia
Kasprzycka, Edwina
Skotnicka, Bożena
Cylwik, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1397400.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
ghrelin
hypertrophied adenoid
insulin-like growth factor-1 (IGF-1)
Opis:
Aim: The aim of the current study was to assess the serum levels of insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children suffering with or without otitis media with effusion before and after adenoidectomy. Material and methods: Serum IGF-1 and ghrelin concentrations were measured with specific enzyme-linked immunoassay (ELISA) methods. The study was carried out in 20 children with otitis media with effusion. The reference group comprised 24 children with hypertrophied adenoid, while control group included 19 children. Results: This mean values of IGF-1 in children with otitis media with effusion and children with hypertrophied adenoid before adenoidectomy were significantly lower than those found in healthy children. Serum levels of IGF-1 were higher after adenoidectomy. There was a significant difference of serum ghrelin levels between both examined groups and the control group. Conclusion: Our results suggest that adenoidectomy in children with hypertrophied adenoids and in children with otitis media with effusion significantly increases the level of IGF-1 in serum compared to before surgery through the effect of the GH-IGF-1 axis, which could contribute to children’s growth.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 4; 13-17
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coexpression of CAV-1, AT1-R and FOXM1 in prostate and breast cancer and normal cell lines and their influence on metastatic properties
Autorzy:
Kowalska, Karolina
Nowakowska, Magdalena
Domińska, Kamila
Piastowska-Ciesielska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1038768.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiotensin II receptor type 1
caveolin-1
breast adenocarcinoma
forkhead M1 transcription factor
prostate adenocarcinoma
Opis:
The aim of this study was to evaluate the coexpression of caveolin-1 (CAV-1), angiotensin II type 1 receptor (AT1-R) and forkhead box Ml (FOXM1) in prostate and breast cancer cell lines, in comparison with normal cell lines. CAV-1, AT1-R and FOXM1 expression was determined by reverse transcription-quantitative polymerase chain reaction and western blot analysis in the prostate cancer cell lines PC3, DU145 and LNCaP; prostate normal cell line PNT1A; breast cancer cell lines MCF-7 and MDA-MB-231; and the normal breast cell line 184A1. A correlation between the expression levels of the investigated genes and their metastatic properties was determined by the Spearman's rank test (P<0.05) and Aspin-Welsch t-test, respectively. In prostate cell lines, a significant correlation was noted between CAV-1 and AT1-R expression and between FOXM1 and CAV-1 expression. A correlation between the expression levels of the investigated genes and their metastatic potential was also observed, with relatively high expression of all the investigated genes in the normal prostate cell line PNT1A. In comparison to prostate cancer cell lines, an adverse dependency between CAV-1, AT1-R, FOXM1 expression and metastatic potential was observed in the breast cancer cell lines. Relatively high expression of all tested genes was observed in the normal breast cell line 184A1, which was decreasing respectively with increasing metastatic potential of breast cancer cell lines. The results obtained here indicate that CAV-1, FOXM1 and AT1-R may be potential markers of tumorigenesis in certain types of cancer in vitro.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 493-499
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential role of transforming growth factor β1 in drug resistance of tumor cells.
Autorzy:
Stoika, Rostyslav
Yakymovych, Mariya
Souchelnytskyi, Serhiy
Yakymovych, Ihor
Powiązania:
https://bibliotekanauki.pl/articles/1043628.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
tumor cells
drug resistance
transforming growth factor b1
Opis:
Acquired drug resistance of tumor cells is frequently observed in cancer patients undergoing chemotherapy. We studied murine leukemia L1210 cells sensitive and resistant to the cytotoxic action of cisplatin and showed that cisplatin-resistant leukemia cells were also refractory to TGF β1-dependent growth inhibition and apoptosis. Addressing the question about the mechanisms responsible for the cross-resistance to cisplatin and TGF β1, we found that cisplatin- and TGF β1-resistant L1210 cells possessed a decreased expression of type I TGF β1 receptor, while the expression of type II TGF β1 receptor was not affected. Western blot analysis of Smad proteins 2, 3, 4, 6, and 7, which participate in signal transduction pathway down-stream of the TGF b1 receptors, revealed an increased expression of Smad 6, inhibiting TGF b1 action, only in cisplatin- and TGF β1-resistant L1210 cells. TGF β1 and especially the cytotoxic mistletoe agglutinin increased Smad 6 expression in TGF β1-sensitive but not in TGF β1-resistant L1210 cells. TGF β1-resistant L1210 cells also differed from TGF β1-sensitive cells by the lack of expression of the pro-apoptotic p53 protein and higher level of expression of the anti-apoptotic Bcl-2 protein. Thus, the described co-expression of tumor cell refractoriness to an anti-cancer drug and to the inhibitory cytokine TGF β1 is accompanied by multiple changes in the TGF β1 signal transduction pathway and in other regulatory systems of the target cells. Besides, we found that various anti-tumor drugs and cytotoxic plant lectins increased the level of TGF b1 expression in both TGF β1-sensitive and -resistant L1210 cells. A hypothesis is proposed that TGF β1 can at least partly mediate the effect of cell-stressing agents and, thus, the development of TGF β1 resistance may be responsible for the appearance of tumor cell refractoriness to the action of some anti-cancer drugs.
Źródło:
Acta Biochimica Polonica; 2003, 50, 2; 497-508
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.
Autorzy:
Kimura, Hideo
Esumi, Hiroyasu
Powiązania:
https://bibliotekanauki.pl/articles/1043646.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
vascular endothelial growth factor
hypoxia inducible factor 1
hypoxia
reciprocal regulation
nitric oxide
Opis:
Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca2+/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 49-59
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
Autorzy:
Grzywacz, Agata
Gdula-Argasińska, Joanna
Muszyńska, Bożena
Tyszka-Czochara, Małgorzata
Librowski, Tadeusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1038990.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metal responsive-transcription factor 1
cell signaling
inflammation
NF-κB
Opis:
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 491-498
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elevated level of ambient glucose stimulates the synthesis of high-molecular-weight hyaluronic acid by human mesangial cells. The involvement of transforming growth factor β1 and its activation by thrombospondin-1
Autorzy:
Yevdokimova, Natalia
Powiązania:
https://bibliotekanauki.pl/articles/1041253.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mesangial cells
high glucose
transforming growth factor β1
hyaluronic acid
thrombospondin-1
Opis:
The dysregulation of the metabolism of glycosaminoglycan and protein components of extracellular matrix (ECM) is a typical feature of diabetic complications. High glucose-induced enrichment of ECM with hyaluronan (HA) not only affects tissue structural integrity, but influences cell metabolic response due to the variety of effects depending on the HA polymer molecular weight. TSP-1-dependent activation of TGFβ1 axis is known to mediate numerous matrix disorders in diabetes, but its role concerning HA has not been studied so far. In this work we demonstrated that 30 mM D-glucose increased the incorporation of [3H]glucosamine in high-molecular-weight (> 2000 kDa) HA of medium and matrix compartments of human mesangial cultures. Simultaneously, the synthesis of HA with lower molecular weight and HA degradation were not altered. The cause of the increased high-molecular-weight HA synthesis consisted in the up-regulation of hyaluronan synthase (HAS) 2 mRNA without alterations of the expression of HAS3, which generates HA of lower molecular weight. D-Glucose at 30 mM also stimulated the production of transforming growth factor β1 (TGFβ1), the excessive activation of which was determined by the up-regulation of thrombospondin-1 (TSP-1). The blockage of TGFβ1 action either by neutralizing anti-TGFβ1 antibodies or by quenching the TGFβ1 activation (with TSP-1-derived synthetic GGWSHW peptide) abolished the effect of high glucose on HAS2 mRNA expression and normalized the synthesis of HA. Exogenous human TGFβ1 had the same effect on HAS2 expression and HA synthesis as high glucose treatment. Therefore, we supposed that TSP-1-dependent TGFβ1 activation is involved in the observed high glucose effect on HA metabolism. Since high-molecular-weight HA polymers, unlike middle- and low-molecular weight HA oligosaccharides, are known to possess anti-inflammatory and anti-fibrotic functions, we suppose that the enrichment of mesangial matrix with high-molecular-weight HA may represent an endogenous mechanism to limit renal injury in diabetes.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 383-393
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphism of insulin-like growth factor IGF-1 gene in selected Polish sheep breeds
Polimorfizm genu insulinopodobnego czynnika wzrostu IGF-1 u wybranych polskich ras owiec
Autorzy:
Niznikowski, R.
Czub, G.
Swiatek, M.
Slezak, M.
Glowacz, K.
Powiązania:
https://bibliotekanauki.pl/articles/2986.pdf
Data publikacji:
2015
Wydawca:
Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
Tematy:
polymorphism
insulin-like growth factor 1
genotype
allele
selected breed
Polska
sheep
animal breed
Opis:
Polymorphism of insulin like growth factor IGF-1gene in selected Polish sheep breeds. Research was carried out in 2009-2013 on 1751 sheep bred in Poland (1366 ♀; 385♂) - 4 meat-wool breeds: Polish Merino, Old type Polish Merino, Corriedale and Żelaźnieńska sheep and 3 meat breeds (Berrichone du cher, Suffolk, Charolaise) from 34 flocks selected randomly across the country. All animals were subjected to identification factor insulin-IGF-1 gene, in the assessment of C and T alleles. Summing up, it should be noted that in 4 meat-wool breeds and 2 meat breeds (Berrichone du cher , Suffolk) there were no polymorphism of alleles and genotypes of insulin-like growth factor (IGF-1) gene, limiting its scope to determine C allele and CC genotype. Only one Charolaise ewe (breed imported from France) had T allele and C:T genotype. That result indicates the need for further research about sheep imported and adapted in Polish production conditions and assess the adaptation process.
Polimorfizm genu insulinopodobnego czynnika wzrostu IGF-1 u wybranych polskich ras owiec. Badania przeprowadzono na 1751 owcach ras hodowanych w Polsce (1366♀ i 385♂) – 4 ras wełnisto-mięsnych: merynos polski, merynos polski starego typu, corriedale i owca żelaźnieńska oraz 3 ras mięsnych (berrichone du cher, suffolk i charolaise) w latach 2009-2013, pochodzących z 34 stad wybranych losowo na obszarze całego kraju. Wszystkie zwierzęta poddane były identyfikacji genu czynnika insulinopodobnego IGF-1, w zakresie oceny występowania alleli C i T. Podsumowując, stwierdzić należy iż u badanych 4 ras wełnisto-mięsnych oraz 2 ras mięsnych (berrichone du cher i suffolk) nie wykazano polimorfizmu występowania alleli i genotypów genu insulinopodobnego czynnika wzrostu IGF-1, ograniczając jego zakres do ustalenia jedynie do allelu C i genotypu CC. U importowanej z Francji rasy charolaise stwierdzono odstępstwo od tej reguły tylko u 1 maciorki posiadającej allel T i genotyp C:T. Wynik ten wskazuje na potrzeby prowadzenia dalszych badań z tego zakresu u owiec pochodzących z importu i adaptowanych w polskich warunkach środowiska produkcyjnego, na podstawie którego można będzie ocenić zakres procesów adaptacyjnych.
Źródło:
Annals of Warsaw University of Life Sciences - SGGW. Animal Science; 2015, 54[2]
1898-8830
Pojawia się w:
Annals of Warsaw University of Life Sciences - SGGW. Animal Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of the frequency of the transforming growth factor beta-1 sequence polymorphisms in patients with alcohol dependence syndrome
Autorzy:
Augustyńska, Beata
Araszkiewicz, Aleksander
Woźniak, Marcin
Grzybowski, Tomasz
Skonieczna, Katarzyna
Woźniak, Alina
Żyła, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1039134.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
transforming growth factor TGFβ-1
alcohol dependence syndrome
TGF-β1 gene
Opis:
Alcohol abuse is one of the most significant factors in the development of liver fibrosis. The pathomechanism of liver fibrosis is the same regardless of its etiology. Fibrosis is a sign of an imbalance between the synthesis of the extracellular matrix components and their degradation. Among the many cytokines that affect hepatic stellate cell activation it seems that transforming growth factor beta (TGF-β) is the most significant, either as the direct factor stimulating polymerase chain reaction (HSC) proliferation and transformation into myofibroblasts, or as the direct factor causing an increase in the activity of genes responsible for the synthesis of extracellular matrix components. The aim of the study was to reveal possible dependencies and differences between the presence of certain alleles of the TGF-β1 gene and its blood level in the study and control group. Blood samples were obtained from 39 patients, the control group consisted of 21 patients. The results obtained in the course of this study showed no statistically significant differences between the frequencies of particular polymorphisms. In the case of haplotype frequencies, insignificant differences were found for the algorithm Excoffier-Laval-Balding predicted haplotypes while one significant difference between the study and control groups was detected in case of the TC haplotype frequency predicted using the Expectation-Maximization algorithm. However, the difference in frequency of TC haplotype predicted by both algorithms was not significant. Genetic analysis of two single nucleotide polymorphisms (SNPs) in exon I of the TGF-β1 gene did not show significant differences between the occurrence of particular polymorphisms and haplotypes in the populations under study.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 63-67
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor β1 gene
Autorzy:
Liberek, Anna
Jakóbkiewicz-Banecka, Joanna
Kloska, Anna
Świderska, Joanna
Kmieć, Zbigniew
Łuczak, Grażyna
Wierzbicki, Piotr
Liberek, Tomasz
Marek, Krzysztof
Plata-Nazar, Katarzyna
Sikorska-Wiśniewska, Grażyna
Kamińska, Barbara
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1039871.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pediatric patients
gene polymorphism
Transforming growth factor β1
inflammatory bowel disease
Opis:
Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 641-644
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 48

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