- Tytuł:
- Unmasking the nature of granulomatosis with polyangiitis – a diagnostic odyssey revealed through a compelling case report
- Autorzy:
-
Sajdak, Piotr
Krużel, Aleksandra
Stodolak, Marcel
Bednarski, Artur
Ziajor, Seweryn
Turski, Mikołaj
Żurowska, Klaudia
Kłos, Kamil
Tomasik, Justyna
Dębik, Marika
Szydłowski, Łukasz - Powiązania:
- https://bibliotekanauki.pl/articles/40614541.pdf
- Data publikacji:
- 2024-06-30
- Wydawca:
- Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
- Tematy:
-
autoimmune diseases
granulomatosis with polyangiitis
vasculitis - Opis:
- Introduction and aim. Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, presents a formidable challenge in the realm of autoimmune diseases. Granulomatosis, characterized by vasculitis and granuloma formation, exhibits diverse clinical manifestations. The rarity of GPA is evident, with an estimated incidence between 0.4 and 11.9 cases per 1 million person-years. The aim of this report is to show the complex diagnostic challenges inherent in GPA, demonstrating the diagnostic process from initial symptoms. Description of the case. This case report unfolds the diagnostic journey of a 52-year-old Caucasian male. The presented case, initially suspected as a respiratory infection, led to a comprehensive investigation owing to persistent symptoms, abnormal blood counts, and elevated inflammatory markers. This narrative aims to depict the patient’s diagnostic journey. Key diagnostic tools include ANCA testing, imaging studies, and tissue biopsy. Pulmonary nodules, lymphangitic changes, and renal involvement culminating in a GPA diagnosis confirmed by positive ANCA and anti-PR3 antibodies. The successful management of this case involved a tailored therapeutic regimen, including cyclophosphamide and methylprednisolone, addressing both vasculitic and renal components. Conclusion. This case contributes to the understanding of atypical presentations of GPA, emphasizing the importance of a holistic and dynamic diagnostic approach.
- Źródło:
-
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 462-468
2544-2406
2544-1361 - Pojawia się w:
- European Journal of Clinical and Experimental Medicine
- Dostawca treści:
- Biblioteka Nauki
Artykuł