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Wyszukujesz frazę "Syrian hamster" wg kryterium: Wszystkie pola

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    Wyświetlanie 1-6 z 6
    Tytuł:
    Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster
    Autorzy:
    Zurawa-Janicka, Dorota
    Kobiela, Jaroslaw
    Stefaniak, Tomasz
    Wozniak, Agnieszka
    Narkiewicz, Joanna
    Wozniak, Michał
    Limon, Janusz
    Lipinska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1040768.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    17-β-estradiol
    HtrA proteases
    estrogen-induced carcinogenesis
    oxidative stress
    Opis:
    Serine proteases HtrA1 and HtrA2 are involved in cellular stress response and development of several diseases, including cancer. Our aim was to examine the involvement of the HtrA proteins in acute oxidative stress response induced in hamster kidney by estrogen treatment, and in nephrocarcinogenesis caused by prolonged estrogenization of male Syrian hamster. We used semi-quantitative RT-PCR to estimate the HtrA1 and HtrA2 mRNA levels in kidney tissues, and Western blotting to monitor the amount of the HtrA proteins. Within the first five hours following estrogen administration both HtrA1 mRNA and the protein levels were increased significantly. No changes in the expression of HtrA2 were observed. This indicates that HtrA1 may be involved in the response against oxidative stress induced by estrogen treatment in hamster kidney. During prolonged estrogenization, a significant reduction of the HtrA1 mRNA and protein levels was observed after 6 months of estradiol treatment, while the expression of HtrA2 was significantly elevated starting from the third month. This suggests an involvement of the HtrA proteins in estrogen-induced nephrocarcinogenesis in hamster. Using fluorescence in situ hybridization we localized the HtrA1 gene at the qb3-4 region of Syrian hamster chromosome 2, the region known to undergo a nonrandom deletion upon prolonged estrogenization. It is possible that the reduced level of HtrA1 expression is due to this chromosomal aberration. A full-length cDNA sequence of the hamster HtrA1 gene was obtained. It codes for a 50 kDa protein which has 98 and 96% identity with mouse and human counterparts, respectively.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 9-20
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Treating the 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinoma in Syrian hamster, Mesocricetus auratus (L) with ethanolic extractives of leaves of mulberry, Morus alba (L).
    Autorzy:
    Khyade, Vitthalrao B.
    Sancer, Aziz
    Powiązania:
    https://bibliotekanauki.pl/articles/1192700.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    7-12-dimethylbenz(a)anthracene
    Buccal pouch carcinoma
    Mesocricetus auratus
    Morus alba
    Mulberry
    Syrian hamster
    Opis:
    The leaf extract of mulberry, Morus alba (L) in ethanol was used to treat the 7,12-dimethylbenz-anthracene (DMBA) - induced carcinoma in the buccal pouch of Syrian hamster, Mesocricetus auratus (L). The 0.5 percent DMBA in liquid paraffin was used for painting the buccal pouch. The DMBA treatment was carried thrice a week for 14 weeks. This was resulted into squamous cell carcinoma. The parameters analyzed include: The tumor incidence, volume and burden. It was followed by oral treatment with ethanolic extractives of mulberry leaves (TpEt) at a dosage of 300 mg/kg, body weight, to DMBA (on alternate days for 14 weeks)- painted animals. Administration of ethanolic extractive of mulberry leaves was found preventing significantly the incidence, volume and burden of the buccal pouch carcinoma. The ethanolic extractive of mulberry leaves exhibited significant effect, especially, the antilipidperoxidation and antioxidative enhancement in DMBA individuals of Syrian hamsters. The results are demonstrating the potency of ethanolic extractive of mulberry leaves for chemoprevention and significant antilipidperoxidative influence in 7,12-dimethylbenz-anthracene (DMBA)- induced carcinoma in the buccal pouch of Syrian hamster, Mesocricetus auratus (L). The activation of caspase through release of cytochrome C through disruption of mitochondrial membrane potential may be the sequence of action of the active principles of mulberry leaf extractives. With it’s bioactive compounds, mulberry, Morus alba (L) may open a new avenue in the cancer prevention and treatment. Taken together, the present attempt provide experimental evidence that leaves of mulberry may have chemopreventive effects on cancerous growth. Mulberry, Morus alba (L) may provide a therapeutic option for controlling the growth of cancer cells.
    Źródło:
    World Scientific News; 2016, 30; 1-13
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relative amount of HMG 1 and HMG 2 proteins in different Syrian hamster tissues
    Względna ilość białek HMG 1 i HMG 2 w różnych tkankach chomika syryjskiego
    Autorzy:
    Modrzejewska, Hanna
    Gałązka, Grażyna
    Kowalska, Ilona
    Powiązania:
    https://bibliotekanauki.pl/articles/944994.pdf
    Data publikacji:
    1988
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Opis:
    Przebadano względną zawartość ilościową białek HMG 1 i HMG 2 w różnych tkankach chomika syryjskiego. Stwierdzono, że zawartość tych białek w półkulach mózgowych, wątrobie prawidłowej, wątrobie nosiciela guza i w wątrobiaku Kirkmana-Robbins jest bardzo podobna i niezależna od występowania dodatkowej subfrakcjl H 1 - H 1 "slow". Względna zawartość białek HMG 1 i HMG 2 różni się w jądrach samców chomika syryjskiego. Ilość HMG 2 przewyższa znacznie zawartość HMG 1.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1988, 6
    0208-614X
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus)
    Autorzy:
    Podgorska, Ewa
    Sniegocka, Martyna
    Mycinska, Marianna
    Trybus, Wojciech
    Trybus, Ewa
    Kopacz-Bednarska, Anna
    Wiechec, Olga
    Krzykawska-Serda, Martyna
    Elas, Martyna
    Krol, Teodora
    Urbanska, Krystyna
    Slominski, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1038358.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    calcitriol
    Syrian golden hamster
    hepatologic toxicity
    nephrologic toxicity
    Opis:
    Although vitamin D is included in the group of fat-soluble vitamins, it must be considered as a prohormone. Its active forms, including calcitriol, have pleiotropic effects and play an important role in the regulation of cell proliferation, differentiation and apoptosis, as well as in hormone secretion, and they demonstrate anti-cancer properties. Since calcitriol delivery can be beneficial for the organism, and Syrian golden hamsters represent a unique experimental model, we decided to investigate its toxicity in this species. In this study, we injected calcitriol intraperitoneally at doses 0 (control), 0.180±0.009 µg/kg and 0.717±0.032 µg/kg. Animal behavior was observed for 72 hrs after injection, and afterwards blood, liver and kidneys were collected for post-mortem examination, electron microscopy, and hematology analyses. The highest dose of calcitriol induced a change in animal behavior from calm to aggressive, and the liver surface showed morphological signs of damage. Following injection of calcitriol, ultrastructural changes were also observed in the liver and kidneys, e.g. vacuolization and increased number of mitochondria. There was also a trend for increased serum levels of aspartate aminotransferase (AST), but not of alanine aminotransferase (ALT) or GGTP (gamma-glutamyl transpeptidase). There was no change in Ca, Mg and P levels, as well as in blood morphology between experimental and control groups. These results indicate that calcitriol at 0.717, but not at 0.180 µg/kg, may induce acute damage to the liver and kidneys, without inducing calcemia. We propose that the hepatotoxic effect of calcitriol in hamster constitutes the primary cause of behavioral changes.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 3; 351-358
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular cloning and sequencing of partial cDNA of tumor necrosis factor and p75 tumor necrosis factor receptor of Syrian golden hamster (Mesocricetus auratus) with the use of universal primers.
    Autorzy:
    Dobrzańska, Zuzanna
    Więckiewicz, Joanna
    Bigda, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1043771.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    PCR primers
    p75 TNF-R
    TNF
    hamster
    Opis:
    In this study we cloned and analysed partial cDNA of tumor necrosis factor (TNF) and p75 TNF-R receptor of Syrian golden hamster (Mesocricetus auratus). We obtained a 382-bp sequence of TNF and a 148-bp sequence coding for p75 TNF-R. The primers used for the cloning were designed on the basis of inter-species homology, thus presumably can be used for cloning and analysis of TNF and p75 TNF-R genes of other mammals.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 2; 427-431
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selenite restores Pax6 expression in neuronal cells of chronically arsenic-exposed Golden Syrian hamsters
    Autorzy:
    Aguirre-Vázquez, Alain
    Sampayo-Reyes, Adriana
    González-Escalante, Laura
    Hernández, Alba
    Marcos, Ricard
    Castorena-Torres, Fabiola
    Lozano-Garza, Gerardo
    Taméz-Guerra, Reyes
    Bermúdez de León, Mario
    Powiązania:
    https://bibliotekanauki.pl/articles/1038549.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    arsenic
    selenite
    α-tocopherol
    neuronal cells
    hamster
    Opis:
    Arsenic is a worldwide environmental pollutant that generates public health concerns. Various types of cancers and other diseases, including neurological disorders, have been associated with human consumption of arsenic in drinking water. At the molecular level, arsenic and its metabolites have the capacity to provoke genome instability, causing altered expression of genes. One such target of arsenic is the Pax6 gene that encodes a transcription factor in neuronal cells. The aim of this study was to evaluate the effect of two antioxidants, α-tocopheryl succinate (α-TOS) and sodium selenite, on Pax6 gene expression levels in the forebrain and cerebellum of Golden Syrian hamsters chronically exposed to arsenic in drinking water. Animals were divided into six groups. Using quantitative real-time reverse transcriptase (RT)-PCR analysis, we confirmed that arsenic downregulates Pax6 expression in nervous tissues by 53 ± 21% and 32 ± 7% in the forebrain and cerebellum, respectively. In the presence of arsenic, treatment with α-TOS did not modify Pax6 expression in nervous tissues; however, sodium selenite completely restored Pax6 expression in the arsenic-exposed hamster forebrain, but not the cerebellum. Although our results suggest the use of selenite to restore the expression of a neuronal gene in arsenic-exposed animals, its use and efficacy in the human population require further studies.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 4; 635-639
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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