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Wyszukujesz frazę "plasma concentration" wg kryterium: Temat


Wyświetlanie 1-10 z 10
Tytuł:
Monitoring of plasma concentration of pyrimethamine (PYR) in infants with congenital Toxoplasma gondii infection – own observations
Monitorowanie stężenia pirymetaminy w surowicy krwi u niemowląt z wrodzonym zarażeniem Toxoplasma gondii – obserwacje własne
Autorzy:
Lipka, B.
Milewska-Bobula, B.
Filipek, M.
Powiązania:
https://bibliotekanauki.pl/articles/837604.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
monitoring
plasma concentration
pyrimethamine
infant
Toxoplasma gondii
infection
congenital disease
treatment
Opis:
The study objective was to determine plasma concentration of pyrimethamine in 24 infants aged 1–5 months, treated for congenital toxoplasmosis. Pyrimethamine was used in a single daily dose at an amount of 0.35–0.98 mg/kg daily, with sulfadiazine (50–100 mg/kg/day) in divided doses 2–3 times a day, and folinic acid given twice a week (7.5 mg). This regimen was continued for 2–6 months, then Fansidar® was administered. Pyrimethamine concentration in plasma was measured using high-performance liquid chromatography method (HPLC). A total of 70 tests were performed. Concentration of pyrimethamine ranged from 0.01 to 1.2 μg/ml. In 14 children (58 tests) the concentration of pyrimethamine achieved therapeutic value. In 7 patients (8 tests) the concentration was below therapeutic level, and in 3 patients (4 tests) above therapeutic level. In 11/24 (46%) children transient moderate neutropenia was observed. Modification of therapy was necessary in 12 patients. Monitoring of pyrimethamine concentration in plasma improves safety and effectiveness of the therapy and is useful in obtaining correct individual dose of the drug. Neutropenia is the most common side-effect of pyrimethamine observed even when using the recommended dose.
Źródło:
Annals of Parasitology; 2011, 57, 2
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Monitoring of plasma concentration of pyrimethamine (PYR) in infants with congenital Toxoplasma gondii infection – own observations
Monitorowanie stężenia pirymetaminy w surowicy krwi u niemowląt z wrodzonym zarażeniem Toxoplasma gondii – obserwacje własne
Autorzy:
Lipka, B.
Milewska-Bobula, B.
Filipek, M.
Powiązania:
https://bibliotekanauki.pl/articles/2143336.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
monitoring
plasma concentration
pyrimethamine
infant
Toxoplasma gondii
infection
congenital disease
treatment
Opis:
The study objective was to determine plasma concentration of pyrimethamine in 24 infants aged 1–5 months, treated for congenital toxoplasmosis. Pyrimethamine was used in a single daily dose at an amount of 0.35–0.98 mg/kg daily, with sulfadiazine (50–100 mg/kg/day) in divided doses 2–3 times a day, and folinic acid given twice a week (7.5 mg). This regimen was continued for 2–6 months, then Fansidar® was administered. Pyrimethamine concentration in plasma was measured using high-performance liquid chromatography method (HPLC). A total of 70 tests were performed. Concentration of pyrimethamine ranged from 0.01 to 1.2 μg/ml. In 14 children (58 tests) the concentration of pyrimethamine achieved therapeutic value. In 7 patients (8 tests) the concentration was below therapeutic level, and in 3 patients (4 tests) above therapeutic level. In 11/24 (46%) children transient moderate neutropenia was observed. Modification of therapy was necessary in 12 patients. Monitoring of pyrimethamine concentration in plasma improves safety and effectiveness of the therapy and is useful in obtaining correct individual dose of the drug. Neutropenia is the most common side-effect of pyrimethamine observed even when using the recommended dose.
Źródło:
Wiadomości Parazytologiczne; 2011, 57, 2; 87-92
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High renin arterial hypertension due to occlusion of the adrenal veins in the rat
Autorzy:
Abramczyk, P
Przybylski, J.
Lisiecka, A.
Papierski, K.
Ciszek, B.
Powiązania:
https://bibliotekanauki.pl/articles/70105.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
kidney function
occlusion
adrenal vein
central adrenal vein
high renin
plasma concentration
blood
adrenal gland
plasma renin
rat
blood pressure
human physiology
adrenorenal rete
arterial hypertension
hormone
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of season on plasma concentration of insulin-like growth factor-I and 1.25-dihydroxycholecalciferol in horses
Wpływ sezonu na koncentrację insulinopodobnego czynnika wzrostu I oraz 1,25 dwuhydroksycholekalcyferolu w osoczu krwi koni
Autorzy:
Luszczynski, J.
Pieszka, M.
Powiązania:
https://bibliotekanauki.pl/articles/44817.pdf
Data publikacji:
2011
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
animal breed
horse
animal sex
vitamin D3
plasma concentration
insulin-like growth factor-1
1,25-dihydroxycholecalciferol
summer season
purebred Arabian breed
Anglo-Arabian horse
Hucul horse
winter season
feeding system
Opis:
During the summer season, plasma concentrations of insulin-like growth factor I (IGF-I) inArabian,Anglo-Arabian and Hucul horses as well as colts and fillies were higher compared to the winter season. Significant differences in IGF-I concentration between the seasons were found in Hucul horses (P≤0.01) and in colts (P≤0.05). Season had no significant effect on 1.25(OH)2-D3 concentration in the horse breeds studied. However, plasma concentrations of this hormone were always higher in the summer than in the winter season regardless of the breed (exceptAnglo-Arabians) and sex. Knowledge and monitoring of the physiological concentrations of IGF-1 and vitamin D3 metabolites in different seasons of the year, combined with analysis of growth rate during these periods may contribute to the improvement of the horse management and feeding system. Because of the association between these hormones and the frequency of developmental orthopaedic diseases, this information could be potentially used in veterinary practice.
W sezonie letnim koncentracja IGF-I w osoczu krwi koni czystej krwi arabskiej, angloarabskich i huculskich a także ogierków i klaczek była wyższa w porównaniu z sezonem zimowym. Istotne różnice w stężeniu IGF-I pomiędzy sezonami wykazano u koni huculskich (P≤0,01) i ogierków (P≤0,05). Nie stwierdzono istotnego wpływu sezonu na koncentrację 1,25(OH)2-D3 u badanych ras koni. Obserwowano jednak, że stężenie tego hormonu w osoczu krwi koni bez względu na rasę (oprócz koni angloarabskich) i płeć było zawsze wyższe w sezonie letnim niż zimowym. Znajomość i monitorowanie fizjologicznych stężeń IGF-I i metabolitów witaminy D3 w różnych porach roku w powiązaniu z analizą tempa wzrostu w tych okresach może przyczynić się do usprawnienia systemu utrzymania i żywienia koni. Ze względu na istniejący związek pomiędzy tymi hormonami a częstotliwością występowania ortopedycznych chorób rozwojowych informacje te mogą też być potencjalnie wykorzystane w praktyce weterynaryjnej.
Źródło:
Acta Scientiarum Polonorum. Zootechnica; 2011, 10, 3
1644-0714
Pojawia się w:
Acta Scientiarum Polonorum. Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of zinc and copper concentrations and the total antioxidant capacity of blood plasma in patients with malabsorption syndrome
Autorzy:
Kanikowska, A.
Wlochal, M.
Mielcarz, G.
Grzymislawski, M.
Kucharski, M.
Powiązania:
https://bibliotekanauki.pl/articles/15256.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
zinc concentration
copper concentration
antioxidant capacity
blood plasma
patient
malabsorption syndrome
microelement
Opis:
Disturbance of the antioxidative-oxidative balance is a predisposing factor in the development of a variety of diseases. Microelements, including zinc and copper, are components of active enzyme regions participating in anti-oxidative systems. Patients with malabsorption syndrome may suffer from diseases related to the chronic deficiency of micro- and macroelements and vitamins, but also experience health problems due to an impaired antioxidative plasma defence, i.e. illnesses caused by oxidative stress. The aim of the study was to assess zinc and copper concentrations as well as the total antioxidant capacity of blood plasma in 33 patients hospitalized in the Department of Internal Medicine, Metabolic Diseases and Dietetics, presenting symptoms of intestinal malabsorption such as weight loss, abdominal pain and diarrhoea. Blood donors made up the control group. Statistically significantly lower concentrations of zinc and copper were found in the study group as compared to the control group for women and men together as well as for women and for men separately (p < 0.05). A significantly lower FRAP (Ferric Reducing Ability of Plasma) value as a measure of blood plasma the total antioxidative capacity was found in the study group of men in comparison with men from the control group (p < 0.05). Patients showed deficiencies of the two microelements despite normal values of BMI (Body Mass Index) and laboratory parameters such as haemoglobin, protein, albumin and iron concentrations. Regardless of the nutritional state assessment, patients with malabsorption syndrome should receive adequate supplementation of vitamins and microelements.
Źródło:
Journal of Elementology; 2015, 20, 4
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A note on distribution of human plasma levels of ascorbic and dehydroascorbic acid
Autorzy:
Capellmann, M
Becka, M.
Bolt, H.M.
Powiązania:
https://bibliotekanauki.pl/articles/70840.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
ascorbic acid
plasma
dehydroascorbic acid
ascorbic acid concentration
Źródło:
Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetics of tramadol and metabolites after injective administrations in dogs
Autorzy:
Giorgi, M.
Del Carlo, S.
Lebkowska-Wieruszewska, B.
Kowalski, C.J.
Saccomanni, G.
Powiązania:
https://bibliotekanauki.pl/articles/30304.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pharmacokinetics
tramadol
metabolite
dog
bioavailability
intravenous injection
intramuscular injection
plasma
tramadol concentration
Opis:
The aim of this study was to determine the pharmacokinetics of tramadol and its main metabolites after IV and IM injections. The pharmacokinetic cross-over study was carried out on 6 healthy male beagle dogs. Tramadol was administered by intravenous (IV) and intramuscular (IM) injection at 4 mg/kg. Tramadol and its main metabolites O-desmethyl-tramadol (M1), N-,N-didesmethyl-tramadol (M2) and N-,O-didesmethyl-tramadol (M5) concentrations were measured in plasma samples by a HPLC coupled with fluorimetric detection; pharmacokinetic evaluations were carried out with a compartmental and non-compartmental model for tramadol and its metabolites, respectively. The bioavailability of the drug, ranging between 84-102% (mean 92%), was within the generally accepted values for a positive bioequivalence decision of (80-125%). After the IM injection the mean plasma drug concentration peak was reached after a Tmax of 0.34 h with a Cmax of 2.52 μg/mL. No therapeutic relevant differences were observed between IM and IV administration. The minimal effective plasma concentration was reached after a few minutes and maintained for about 6-7 h in both administrations. M1 plasma concentration was low and the amounts of the other metabolites produced were analogous in both routes of administration. In conclusion, tramadol was rapidly and almost completely absorbed after IM administration and its systemic availability was equivalent to the IV injection. The different onset time and duration of action observed were very small and probably therapeutically irrelevant. The IM injection is a useful alternative to IV injection in the dog.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Magnesium concentration in plasma and tissues of patients undergoing surgery for stomach and large intestine cancer
Stezenie magnezu w osoczu i tkankach pacjentow leczonych operacyjnie z powodu raka zoladka i jelita grubego
Autorzy:
Szewczyk, M
Pasternak, K.
Andrzejewski, A.
Dabrowski, A.
Wallner, G.
Powiązania:
https://bibliotekanauki.pl/articles/13687.pdf
Data publikacji:
2009
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
human disease
large intestine cancer
stomach cancer
cancer
surgery
surgical treatment
patient
plasma
tissue
magnesium concentration
Opis:
Digestive system neoplasms pose a serious health problem both in Poland and abroad. Neoplasms are frequently considered to be caused by impaired homeostasis in the human body. Development of neoplasms may be linked to disturbances in concentration of elements, including magnesium as a major intracellular cation. The objective of this study was to evaluate the concentration of magnesium in plasma and tissue samples taken from patients suffering from neoplasms of the stomach or the large intestine. The study involved 35 patients, including 20 affected by stomach cancer and 15 suffering from large intestine cancer. The patients were in the age rage of 36-77. The material included blood samples taken from patients before and seven days after surgery, as well as samples of cancerous and healthy tissues. The colorimetric method with a Genesis spectrophotometer was used for determination of magnesium concentration. A statistically significant difference was observed between plasma magnesium concentration in patients affected by stomach cancer and the normal range. Elevated values of magnesium concentration measured on the seventh day after the procedure as compared to the concentration before the procedure was noted, however, the difference was statistically insignificant. No significant differences were observed in magnesium concentration measured before and after the procedure, or in comparison to the normal range in patients with large intestine cancer. Determination of tissue magnesium showed that magnesium concentration was higher in cancerous than in healthy tissue. Obtained results demonstrate that magnesium homeostasis is impaired in patients, which may be important in the pathoghenesis of digestive system neoplasms.
Nowotwory przewodu pokarmowego stanowią istotny problem zdrowotny zarówno w Polsce, jak i na całym świecie. Przyczyny nowotworów często upatruje się w zaburzeniach homeostazy organizmu. Rozwój nowotworów może wiązać się z zaburzeniem stężenia pierwiastków, w tym również magnezu będącego najważniejszym kationem wewnątrzkomórkowym. Celem pracy była ocena stężenia magnezu w osoczu i wycinkach tkanek nowotworowych chorych na raka żołądka i raka jelita grubego. Badania wykonano u 35 pacjentów, w tym u 20 chorych na raka żołądka, oraz 15 chorych na raka jelita grubego. Badani byli w przedziale wiekowym od 36 do 77 lat. Materiał do badań stanowiła krew chorych pobierana przed zabiegiem operacyjnym oraz w 7. dobie po zabiegu, a także wycinki tkanek zmienionych nowotworowo i zdrowych. Stężenie magnezu oznaczano metodą kolorymetryczną z użyciem spektrofotometru firmy Genesis. U chorych na raka żołądka wykazano istotną statystycznie różnicę w stężeniu magnezu w osoczu w porównaniu z normą. Zaobserwowano również wyższe stężenie magnezu w 7. dobie po zabiegu w porównaniu ze stężeniem przed operacją, jednak różnica ta była nieistotna statystycznie. Natomiast w przypadku raka jelita grubego nie wykazano różnic istotnych statystycznie zarówno w stężeniu magnezu przed i po zabiegu, jak i przy porównaniu wyników stężeń magnezu z normą. Badając stężenie magnezu w tkankach, stwierdzono wyższe stężenie magnezu w tkance nowotworowej w porównaniu z tkanką zdrową. Wyniki wskazują na istnienie zaburzeń homeostazy magnezu u chorych, co może mieć znaczenie w patogenezie nowotworów przewodu pokarmowego.
Źródło:
Journal of Elementology; 2009, 14, 3; 563-571
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of dietary fat type on plasma lipid profile and leptin concentration in rats fed on high-sucrose diets
Autorzy:
Krawczynska, A.
Okreglicka, K.
Olczak, E.
Gromadzka-Ostrowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/3460.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
dietary fat
fat type
plasma lipid profile
leptin concentration
rat
high sucrose diet
diet
linseed oil
grape seed oil
lipid profile
lard
human nutrition
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Badanie wpływu rodzaju układu wprowadzania próbki do plazmy ICP na wybrane parametry związane z granicą wykrywalności
Research on the impact of the type of the system for introduction of samples into ICP plasma on selected parameters associated with the limit of detection
Autorzy:
Kozak, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1834117.pdf
Data publikacji:
2020
Wydawca:
Instytut Nafty i Gazu - Państwowy Instytut Badawczy
Tematy:
optyczna spektrometria emisyjna plazmy indukcyjnie sprzężonej
układy wprowadzania próbki
granica wykrywalności
równoważne stężenie w tle
optical emission spectrometry of inductively coupled plasma
sample introduction systems
detection limit
background equivalent concentration
Opis:
The article describes the research on the impact of the type of system for introduction of samples into ICP plasma on selected parameters associated with the limit of detection. For this purpose, several sample introduction systems were chosen and tested by assessing the selected analytical parameters: Limit of Detection (LOD) and, additionally, Background Equivalent Concentration (BEC). The tests were carried out for 26 elements for which 48 spectral lines were selected. The sum of LOD and BEC values (determined for each line of a given element, for each of the sample introduction systems) were used for general comparison of the applied sample introduction systems. Based on the obtained results, the best sample introduction systems were selected for multi-element analysis, for which the lowest total LOD and BEC values were obtained. Graphs were also prepared showing the dependence of each of the LOD and BEC parameters on the spectral lines of selected elements. The analysis of the graphs allowed for grouping selected elements, based on the lines provided for measurements, in terms of the impact of the applied sample introduction system on LOD and BEC parameters, into three groups: element lines for which the weak influence of the used sample introduction system on LOD and BEC parameters is observed. This group includes the following element lines: Be 313.042, Cd 214.438, Cd 226.502, Mg 279.553, Mg 280.270, Mg 258.213, Mn 257.611, Mn 259.373, Sr 407.771 and Sr 421.552, element lines for which a moderate effects of the applied sample introduction system on LOD and BEC parameters are observed. This group includes the following element lines: Ag 328.068, As 189.04, As 193.759, Cu 324.754, Cu 327.396, Tl 190.090, V 292.402, V 292.464, V 311.071 and element lines for which the largest impact of the applied sample introduction system on LOD and BEC parameters is observed, this group includes the following element lines: K 766.491, Na 588.995, Na 589.592, Se 204.050, Sb 217.581, Ca 393.336. This information can be helpful when selecting the system for introduction of samples into the ICP OES spectrometer enabling the determination of a given element with the lowest detection limit.
Źródło:
Nafta-Gaz; 2020, 76, 9; 620-629
0867-8871
Pojawia się w:
Nafta-Gaz
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-10 z 10

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