Temat: iron homeostasis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines.
Autorzy:: Kruszewski, Marcin
Iwaneńko, Teresa
Powiązania:: https://bibliotekanauki.pl/articles/1043668.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: iron homeostasis
hydrogen peroxide
comet assay
Opis:: Labile iron pool (LIP) constitutes a crossroad of metabolic pathways of iron-containing compounds and is midway between the cellular need for iron, its uptake and storage. In this study we investigated oxidative DNA damage in relation to the labile iron pool in a pair of mouse lymphoma L5178Y (LY) sublines (LY-R and LY-S) differing in sensitivity to hydrogen peroxide. The LY-R cells, which are hydrogen peroxide-sensitive, contain 3 times more labile iron than the hydrogen peroxide-resistant LY-S cells. Using the comet assay, we compared total DNA breakage in the studied cell lines treated with hydrogen peroxide (25 μM for 30 min at 4°C). More DNA damage was found in LY-R cells than in LY-S cells. We also compared the levels of DNA lesions sensitive to specific DNA repair enzymes in both cell lines treated with H2O2. The levels of endonuclease III-sensitive sites and Fapy-DNA glycosylase-sensitive sites were found to be higher in LY-R cells than in LY-S cells. Our data suggest that the sensitivity of LY-R cells to H2O2 is partially caused by the higher yield of oxidative DNA damage, as compared to that in LY-S cells. The critical factor appears to be the availability of transition metal ions that take part in the OH radical-generating Fenton reaction (very likely in the form of LIP).
Źródło:: Acta Biochimica Polonica; 2003, 50, 1; 211-215
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The role of iron regulatory proteins in the control of iron metabolism in mammals
Autorzy:: Stys, A.
Starzynski, R.R.
Lipinski, P.
Powiązania:: https://bibliotekanauki.pl/articles/80193.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: duodenal enterocyte
ferritin
hepatocyte
hydrogen peroxide
inflammation
iron homeostasis
iron metabolism
iron regulated protein
iron regulatory element
mammal
mRNA
nitric oxide
reticuloendothelial macrophage
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 1
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Obesity and iron metabolism
Autorzy:: Zekanowska, E.
Boinska, J.
Giemza-Kucharska, P.
Kwapisz, J.
Powiązania:: https://bibliotekanauki.pl/articles/80448.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: adipocyte
adipose tissue
body fat
body mass index
child
endocrine organ
harmful effect
hepcidin
interleukin 1
interleukin 6
iron deficiency
iron homeostasis
iron metabolism
obesity
overweight
proinflammatory cytokine
tumour necrosis factor-alpha
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Iron in cattle health
Autorzy:: Wysocka, D.
Snarska, A.
Sobiech, P.
Powiązania:: https://bibliotekanauki.pl/articles/1192099.pdf
Data publikacji:: 2020
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:: cattle
iron
trace element homeostasis
Opis:: Iron is one of the most abundant elements on Earth, a vital component of every living organism, and an essential micronutrient for all animal species. The primary source of iron for calves and other new-born ruminants is milk or a milk replacer, while for adults it is forage. Drinking water can contain various amounts of Fe ions and can be a source of this element as well. Systemic iron homeostasis in vertebrates is mostly regulated by hepcidin (HEP), a peptide synthesized and secreted by hepatocytes. The largest amounts of iron in the body are incorporated into proteins, mainly haemoglobin and myoglobin. This element participates in several biochemical processes including blood production, transport of oxygen, energy metabolism and immune processes. Iron deficiency can result in so-called iron deficiency anaemia, mostly occurring in young calves due to low iron content in cow’s milk and high demand for this element by calf’s organism. Iron poisoning mostly occurs due to excess iron intake caused by an inappropriate dose of iron given to animals (injection or per os administration) or accidental consumption of high doses of supplements. Excess iron intake can cause overload and damage of internal organs. Oxidation of ferrous iron in haemoglobin can result in methemoglobinemia and an inability of erythrocytes to carry oxygen. In recent years, scientists have implicated some questions regarding iron and ruminants that need re-evaluation or further investigation, e.g. the upper tolerable concentration of Fe in drinking water, the relationship between inflammation and iron status, serum Fe as an indicator of inflammation, or ferritin as a predictive factor for iron deficiency anaemia in cattle.
Źródło:: Journal of Elementology; 2020, 25, 3; 1175-1185
1644-2296
Pojawia się w:: Journal of Elementology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: How copper excess influences homeostasis of the bank vole (Myodes glareolus)
Autorzy:: Miska-Schramm, A.
Zakrzewska, M.
Hajduk, J.
Kruczek, M.
Powiązania:: https://bibliotekanauki.pl/articles/1189831.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:: copper
iron
zinc
bank vole
homeostasis
Opis:: Copper is a physiologically occurring trace element, the availability of which to wild small mammals is constantly increasing. This research deals with the questions of how copper in doses equivalent to those found in the natural environment from polluted areas (Cu I – 150 mg kg-1, Cu II – 600 mg kg-1) influences homeostasis of small rodents. The following were used as indicators: ratios of organs to body mass, blood parameters (haematocrit, haemoglobin), copper, iron and zinc concentrations in selected tissues and in excrements. The bank vole was used as a model species (n = 72). Haematocrit was assessed using a haematocrit reader, while haemoglobin was determined with a spectrophotometer. The content of Cu, Fe and Zn was analyzed using the flame method. Ratios of the liver and kidneys to body mass were significantly lower in animals exposed to 600 mg kg-1 Cu than in the control. Copper accumulated in the liver, kidneys, brain and excrements of the Cu II animals of both sexes. It also influenced the iron and zinc homeostasis by decreasing the iron concentration in the kidneys of both sexes, in the liver of females and in male testes. Additionally, it caused a decline in iron excretion in females. Compared to the control, the zinc concentration was significantly higher in the liver and brain of animals exposed to copper solutions as well as in the kidneys of copper treated males. Along with an increase in copper, the zinc concentration in faeces decreased significantly. In conclusion, copper pollution influences negatively the homeostasis of small mammals. Consequently it may interfere with trophic chains, which could affect adversely the degree of biodiversity.
Źródło:: Journal of Elementology; 2017, 22, 2; 617-628
1644-2296
Pojawia się w:: Journal of Elementology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: An overall view of the process of the regulation of human iron metabolism
Autorzy:: Formanowicz, D.
Formanowicz, P.
Powiązania:: https://bibliotekanauki.pl/articles/79993.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: absorption
gastrointestinal tract
enterocyte
erythropoietin
ferroportin
ferrous ion
hepcidin
homeostasis
iron
iron metabolism
oxygen radical
stomach
transferrin
transportation
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Biofortification - promising approach to increasing the content of iron and zinc in staple food crops
Biofortyfikacja - obiecujący sposób zwiększania zawartości żelaza i cynku w podstawowych roślinach uprawnych
Autorzy:: Garcia-Banuelos, M.L.
Sida-Arreola, J.P.
Sanchez, E.
Powiązania:: https://bibliotekanauki.pl/articles/15687.pdf
Data publikacji:: 2014
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:: biofortification
iron content
zinc content
food crop
metal
homeostasis
micronutrient
malnutrition
anaemia
bioavailability
Opis:: Micronutrient deficiencies have increased over recent decades due to the general depreciation of the quality of poor people’s diet, both in developed and developing countries. The deficiencies of iron (Fe) and zinc (Zn) are a critical public health problem worldwide, with the negative impact on health, lifespan and productivity. Biofortification is an agricultural approach that can improve human nutrition on a global scale. Agronomic biofortification is considered a short-term and complementary strategy, but economic analyses suggest that genetic biofortification is the most effective strategy for increasing dietary Fe and Zn intakes of vulnerable populations. Enrichment of cereal grains by breeding is a high-priority area of research, and an effective strategy among other approaches, e.g, fortification, supplementation and food diversification. This review discusses the role of Fe and Zn in plant nutrition, the potential strategies for developing Fe and Zn biofortified crops and their importance in human nutrition.
Obecnie niedobory Fe i Zn stanowią istotny problem dotyczący zdrowia publicznego, są bowiem przyczyną negatywnego wpływu na zdrowie, średnią długość życia i przyrost naturalny. Biofortyfikacja agronomiczna jest to metoda, która może poprawić żywienie człowieka na całym świecie. Analizy ekonomiczne wskazują, że genetyczna biofortyfikacja jest najbardziej skuteczną strategią zwiększenia spożycia Fe i Zn, natomiast agronomiczna biofortifikacja może być podejściem komplementarnym, i to w krótkim czasie. Strategia genetyczna jest obszarem priorytetowym w badaniach zboża, i okazuje się być bardziej skuteczna niż metody fortyfikacji, suplementacji lub zróżnicowania środków spożywczych. W pracy omówiono rolę Fe i Zn w odżywianiu roślin, potencjalne strategie rozwoju upraw z wykorzystaniem biofortyfikacji Fe i Zn oraz znaczenie tych upraw w żywieniu człowieka.
Źródło:: Journal of Elementology; 2014, 19, 3
1644-2296
Pojawia się w:: Journal of Elementology
Dostawca treści:: Biblioteka Nauki

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