- Tytuł:
- Formation of lipid droplets induced by 2,3-dihydrogeranylgeranoic acid distinct from geranylgeranoic acid
- Autorzy:
-
Kodaira, Yuichi
Kusumoto, Takeru
Takahashi, Takeshi
Matsumura, Yoshihiro
Miyagi, Yukino
Okamoto, Kyoko
Shidoji, Yoshihiro
Sagami, Hiroshi - Powiązania:
- https://bibliotekanauki.pl/articles/1040868.pdf
- Data publikacji:
- 2007
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
lipid droplets
geranylgeranoic acid
2,3-dihydrogeranylgeranoic acid
HL-60
neutrophils - Opis:
- Geranylgeranoic acid (GGA) and 2,3-dihydrogeranylgeranoic acid (2,3-diGGA) are geranylgeraniol-derived metabolites (Kodaira et al. (2002) J Biochem 132: 327-334). In the present study, we examined the effects of these acids on HL-60 cells. The cells were differentiated into neutrophils by GGA stimulation like retinoic acid stimulation. In the case of cells stimulated with 2,3-diGGA, neutrophils were not detected, but the formation of lipid droplets was induced. On the other hand, when the cells were cultured in the presence of 0.1% FBS instead of 10% FBS, apoptotic cells were induced not only by GGA stimulation but also with 2,3-diGGA. In the latter case, when the cells were cultured in the co-presence of a caspase-3 inhibitor (Ac-DMQD-CHO), the lipid droplets formation was observed in the cells. These results suggest that GGA and 2,3-diGGA are extremely different from each other with respect to their effects on HL-60 cells.
- Źródło:
-
Acta Biochimica Polonica; 2007, 54, 4; 777-782
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł