Temat: A-549 - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: DESIGN, SYNTHESIS AND ANALYSIS OF ANTICANCER ACTIVITY OF NEW SAR-BASED S16020 DERIVATIVES
Autorzy:: Tylińska, Beata
Jasztold-Howorko, Ryszard
Kowalczewska, Karina
Szczaurska-Nowak, Katarzyna
Gębarowski, Tomasz
Wietrzyk, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/895419.pdf
Data publikacji:: 2018-12-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: A549
cytostatic
olivacine
S16020
NHDF
A498
Opis:: A novel set of S16020 derivatives was designed applying structure activity relationships (SAR). The newly synthesized compounds were subjected to in vitro cytostatic activity screening against human kidney cancer (cell line A498), human lung cancer (cell line A549) and normal human dermal fibroblasts (cell line NHDF). Two 6H-pyrido[4,3-b]carbazole derivatives exhibited stronger potency against both investigated cell lines than the reference compounds ellipticine and doxorubicin.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1313-1320
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Antimicrobial property and antiproliferative activity of Centaurea babylonica (L.) L. on human carcinomas and cervical cancer cell lines
Autorzy:: Guvensen, N.C.
Keskin, D.
Gunes, H.
Oktay, M.K.
Yildirim, H.
Powiązania:: https://bibliotekanauki.pl/articles/2083066.pdf
Data publikacji:: 2019
Wydawca:: Instytut Medycyny Wsi
Tematy:: Centaura babylonica
antimicrobial activity
antiproliferative activity
A-549
PC-3
MCF-7 and HeLa cell lines
chemical
composition
GC-MS
Opis:: Introduction and objective. Since antiquity, C. babylonica (L.) L. extracts has been used as a remedy for primary health care in traditional medicine. In this study, a total of seven different crude extracts (acetone, chloroform, hexane, ethylacetate, methanol, ethanol and water) from branches and leaves of C. babylonica (L.) L. were prepared to determine antimicrobial and antiproliferative activity against cancer cell lines. Materials and method. MIC assay was used for antimicrobial activity against gram positive and gram negative bacteria, and one yeast. MTT assay was applied to screen the antiproliferative activity of seven extracts, and to determine dose- and time-dependent effects of the aceton extract on A549, PC-3, MCF-7, and HeLa cell lines. Results. The aceton extract of C.babylonica (L.) L. showed the best antibacterial activity against Bacillus cereus, P. aeruginosa and C. albicans (MIC: 1.6 mg/mL). GC-MS analyses allowed six compounds to be determined; the main constituents of acetone extract from C. babylonica (L.) L. were diacetone alcohol (53.47 %), 1-dexadecene (10.19 %) and 1-tetradecene (8.67 %). In addition, seven different solvent extracts at 500 μg/mL caused antiproliferative activity between 84% – 88%, compared to control. Dose-dependent effects of the extracts on A549 cells indicated that chloroform, ethyl acetate, and aceton extract were the most effective extracts with the IC50 values of 9, 33, and 36 μg/mL, respectively. Conclusions. The results clearly demonstrate that C. babylonica (L.) L. exhibited a strong antimicrobial effect and antiproliferative activity against cancer cells in vitro. Further studies are required to isolate and characterize the active pure compounds responsible for the antimicrobial and antiproliferative activities.
Źródło:: Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 290-297
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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