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Tytuł:
Metody oznaczania subpopulacji limfocytów. I. Ocena metod izolacji limfocytów z krwi obwodowej
Autorzy:
Kruszewski, J.
Szczylik, C.
Szewczyk, E.
Wiktor-Jędrzejczak, W.
Powiązania:
https://bibliotekanauki.pl/articles/2188624.pdf
Data publikacji:
1979
Wydawca:
Polskie Towarzystwo Diagnostyki Laboratoryjnej
Źródło:
Diagnostyka Laboratoryjna; 1979, 15, 5; 211-214
0867-4043
Pojawia się w:
Diagnostyka Laboratoryjna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiple colon perforation as a fatal complication during treatment of metastatic melanoma with ipilimumab – case report
Autorzy:
Dilling, Paweł
Walczak, Jakub
Pikiel, Paweł
Kruszewski, Wiesław J.
Powiązania:
https://bibliotekanauki.pl/articles/1395708.pdf
Data publikacji:
2014-02-01
Wydawca:
Index Copernicus International
Tematy:
melanoma
ipilimumab
anti-CTLA4
complications
Opis:
Ipilimumab, an anticancer drug, is an anti-CTLA4 monoclonal antibody. It is used in treatment of disseminated melanoma. Therapy is associated with high risk of complications. One of the most serious, although one of the rarest is perforation of gastrointestinal tract. In this case report we describe a 52-year old male, with disseminated melanoma with unknown starting point, treated with anti- CTLA4 monoclonal antibody. After 3rd dose of drug administration, bloody diarrhea and acute abdominal pain occurred as a symptom of gastrointestinal perforation. A single perforation was sutured during laparotomy. Symptoms of acute abdomen returned after 10 days. Pus-faecalperitonitis, symptoms of necro-hemorrhagic colitis and multilocal perforation of the colon were found during relaparotomy. Pancolectomy with end ileostomy was performed. Few hours since relaparotomy pacient died due to multiple organ failure. The purpose of this case report is to draw attention to a risk of multilocal colon perforation in patient treated with ipilumumab.
Źródło:
Polish Journal of Surgery; 2014, 86, 2; 94-96
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Jakość życia kobiet w Polsce z rakiem piersi leczonych mastektomią i rekonstrukcją piersi jest taka sama jak po leczeniu oszczędzającym pierś
Autorzy:
Szutowicz-Wydra, Beata
Wydra, Jacek
Ciesielski, Maciej
Kruszewski, Wiesław J
Szajewski, Mariusz
Walczak, Jakub
Hansdorfer-Korzon, Rita
Powiązania:
https://bibliotekanauki.pl/articles/1393927.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
rak piersi
leczenie chirurgiczne
jakość życia
Opis:
Chirurgiczne nowoczesne leczenie raka piersi oferuje pacjentkom różne możliwości. Jakość życia po leczeniu chirurgicznym może być czynnikiem decydującym o wyborze rodzaju leczenia: leczenia oszczę- dzającego pierś lub mastektomii z rekonstrukcją piersi. Wiedzę o różnicach jakości życia pacjentek czerpiemy z badań porównawczych, prowadzonych często w krajach różniących się kulturowo i spo- łecznie od Polski. Celem pracy była ocena jakości życia kobiet po leczeniu chirurgicznym. Materiał i metodyka. Do badania włączono pacjentki operowane z powodu raka piersi w okresie od września 2010 do listopada 2013 r. na Oddziale Chirurgii Onkologicznej Gdyńskiego Centrum Onkologii Szpitala Morskiego im. PCK w Gdyni. Wykonano 82 zabiegi rekonstrukcji piersi u 79 kobiet (u 3 pacjentek wykonano zabieg obustronnie) oraz 226 zabiegów oszczędzających pierś. Ocenę jakości życia przeprowadzono z użyciem kwestionariuszy EORTC QLQ-C30 i EORTC QLQ-BR23. Wyniki. Jakość życia kobiet w ujęciu globalnym była wysoka w obu badanych grupach i nie różniła się statystycznie. Postrzeganie własnego ciała było nieznacznie lepsze w grupie poddanej leczeniu oszczędzającemu pierś, jednak funkcjonowanie w sferze seksualnej niższe niż u pacjentek leczonych mastektomią z rekonstrukcją piersi. Kobiety w obu grupach obawiały się o swoją przyszłość. Dolegliwości związane z chorobą nowotworową i leczeniem nie były uciążliwe. Wnioski. Jakość życia Polek z rakiem piersi leczonych z zaoszczędzeniem gruczołu piersiowego lub mastektomią z rekonstrukcją jest wysoka i się nie różni. Konieczne jest wprowadzenie działań mających na celu obniżenie poziomu lęku związanego z chorobą oraz poprawa w zakresie funkcjonowania pacjentek w sferze seksualnej.
Źródło:
Polish Journal of Surgery; 2016, 88, 5; 464-474
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thermoelectric properties of bismuth-doped magnesium silicide obtained by the self-propagating high-temperature synthesis
Autorzy:
Bucholc, Bartosz
Kaszyca, Kamil
Śpiewak, Piotr
Mars, Krzysztof
Kruszewski, Mirosław J.
Ciupiński, Łukasz
Kowiorski, Krystian
Zybała, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/2173670.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
thermoelectric materials
magnesium silicide
bismuth doping
SHS
self-propagating high-temperature synthesis
spark plasma sintering
materiały termoelektryczne
krzemek magnezu
doping bizmutem
samorozwijająca się wysokotemperaturowa synteza
iskrowe spiekanie plazmowe
Opis:
Doping is one of the possible ways to significantly increase the thermoelectric properties of many different materials. It has been confirmed that by introducing bismuth atoms into Mg sites in the Mg2Si compound, it is possible to increase career concentration and intensify the effect of phonon scattering, which results in remarkable enhancement in the figure of merit (ZT) value. Magnesium silicide has gained scientists’ attention due to its nontoxicity, low density, and inexpensiveness. This paper reports on our latest attempt to employ ultrafast self-propagating high-temperature synthesis (SHS) followed by the spark plasma sintering (SPS) as a synthesis process of doped Mg2Si. Materials with varied bismuth doping were fabricated and then thoroughly analyzed with the laser flash method (LFA), X-ray diffraction (XRD), scanning electron microscopy (SEM) with an integrated energy-dispersive spectrometer (EDS). For density measurement, the Archimedes method was used. The electrical conductivity was measured using a standard four-probe method. The Seebeck coefficient was calculated from measured Seebeck voltage in the sample subjected to a temperature gradient. The structural analyses showed the Mg2Si phase as dominant and Bi2Mg3 located at grain boundaries. Bismuth doping enhanced ZT for every dopant concentration. ZT = 0.44 and ZT=0.38 were obtained for 3wt% and 2wt% at 770 K, respectively.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2022, 70, 3; art. no. e141007
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thermoelectric properties of bismuth-doped magnesium silicide obtained by the self-propagating high-temperature synthesis
Autorzy:
Bucholc, Bartosz
Kaszyca, Kamil
Śpiewak, Piotr
Mars, Krzysztof
Kruszewski, Mirosław J.
Ciupiński, Łukasz
Kowiorski, Krystian
Zybała, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/2173729.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Doping is one of the possible ways to significantly increase the thermoelectric properties of many different materials. It has been confirmed that by introducing bismuth atoms into Mg sites in the Mg2Si compound, it is possible to increase career concentration and intensify the effect of phonon scattering, which results in remarkable enhancement in the figure of merit (ZT) value. Magnesium silicide has gained scientists’ attention due to its nontoxicity, low density, and inexpensiveness. This paper reports on our latest attempt to employ ultrafast self-propagating high-temperature synthesis (SHS) followed by the spark plasma sintering (SPS) as a synthesis process of doped Mg2Si. Materials with varied bismuth doping were fabricated and then thoroughly analyzed with the laser flash method (LFA), X-ray diffraction (XRD), scanning electron microscopy (SEM) with an integrated energy-dispersive spectrometer (EDS). For density measurement, the Archimedes method was used. The electrical conductivity was measured using a standard four-probe method. The Seebeck coefficient was calculated from measured Seebeck voltage in the sample subjected to a temperature gradient. The structural analyses showed the Mg2Si phase as dominant and Bi2Mg3 located at grain boundaries. Bismuth doping enhanced ZT for every dopant concentration. ZT = 0.44 and ZT=0.38 were obtained for 3wt% and 2wt% at 770 K, respectively.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2022, 70, 3
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Same quality of life for polish breast cancer patients treated with mastectomy and breast reconstruction or breast-conserving therapy
Autorzy:
Szutowicz-Wydra, Beata
Wydra, Jacek
Ciesielski, Maciej
Kruszewski, Wiesław J
Szajewski, Mariusz
Walczak, Jakub
Hansdorfer-Korzon, Rita
Powiązania:
https://bibliotekanauki.pl/articles/1393915.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
breast cancer
breast surgery
quality of life
Opis:
Breast cancer often requires combined oncologic treatments, the base of which is surgery. Quality of life (QoL) after each surgical procedure may influence the process of decision making among women, who qualify for multiple oncological strategies. Our knowledge about QoL in breast cancer patients is derived from comparative studies. Results may differ, depending on country, culture, and societal relations. The aim of the study was to investigate the quality of life of Polish patients treated with breastconserving therapy (BCT) or mastectomy with breast reconstruction. Material and methods. The study involved women who underwent surgery for breast cancer in the Department of Surgical Oncology of the Gdynia Oncology Center from September 2010 to November 2013. Eighty-two breast reconstructions (in 79 patients) and 226 BCT procedures were performed. QoL was measured with the use of EORTC QLQ-C30 and QLQ-BR23 questionnaires. Results. Global QoL was high in both groups and did not differ significantly. Body image was slightly better after BCT than after mastectomy with breast reconstruction, but sexual QoL was lower. Future perspective was quite low in both groups. Disease symptoms were not bothering. Conclusions. The global QoL among Polish breast cancer patients treated with BCT or mastectomy with breast reconstruction is high and does not differ between groups. There is a need for anxiety and disease-related fear prophylaxis and for the improvement of sex life of breast cancer survivors.
Źródło:
Polish Journal of Surgery; 2016, 88, 5; 464-474
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of nanostructured bulk cobalt triantimonide doped with tellurium and indium prepared by pulsed plasma in liquid method
Autorzy:
Zybała, R.
Schmidt, M.
Kaszyca, K.
Chmielewski, M.
Kruszewski, M. J.
Jasiński, M.
Rajska, M.
Ciupiński, Ł.
Powiązania:
https://bibliotekanauki.pl/articles/200831.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
thermoelectric materials
nanostructured materials
skutterudite
energy harvesting
spark plasma sintering
Opis:
One of the ways to decrease thermal conductivity is nano structurization. Cobalt triantimonide (CoSb3) samples with added indium or tellurium were prepared by the direct fusion technique from high purity elements. Ingots were pulverized and re-compacted to form electrodes. Then, the pulsed plasma in liquid (PPL) method was applied. All materials were consolidated using rapid spark plasma sintering (SPS). For the analysis, methods such as X-ray diffraction (XRD), scanning electron microscopy (SEM) and scanning transmission electron microscopy (STEM) with a laser flash apparatus (LFA) were used. For density measurement, the Archimedes’ method was used. Electrical conductivity was measured using a standard four-wire method. The Seebeck coefficient was calculated to form measured Seebeck voltage in the sample placed in a temperature gradient. The preparation method allowed for obtaining CoSb3 nanomaterial with significantly lower thermal conductivity (10 Wm–1K–1 for pure CoSb3 and 3 Wm–1K–1 for the nanostructured sample in room temperature (RT)). The size of crystallites (from SEM observations) in the powders prepared was about 20 nm, joined into larger agglomerates. The Seebeck coefficient, α, was about –200μVK–1 in the case of both dopants, In and Te, in microsized material and about −400 μK−1 for the nanomaterial at RT. For pure CoSb3 , α was about 150 μVK−1 and it stood at −50 μVK−1 for nanomaterial at RT. In bulk nanomaterial samples, due to a decrease in electrical conductivity and inversion of the Seebeck coefficient, there was no increase in ZT values and the ZT for the nanosized material was below 0.02 in the measured temperature range, while for microsized In-doped sample it reached maximum ZT = 0.7 in (600K).
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2020, 68, 1; 125-134
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ammonium minerals from burning coal-dumps of the Upper Sileian Coal Basin (Poland)
Autorzy:
Parafiniuk, J.
Kruszewski, Ł.
Powiązania:
https://bibliotekanauki.pl/articles/2059219.pdf
Data publikacji:
2009
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
Upper Silesian Coal Basin
burning coal-dumps
salammoniac
tschermigite
ammonium minerals
godovikovite
Opis:
Assemblages composed of 11 ammonium min er als, mainly sulphates and chlorides, were recorded from four burning coal-dumps (BCD) in the Upper Silesian Coal Ba sin. Most of them are newly recorded from Poland. Minerals were identified using PXRD and SEM with EDS analyses. Salammoniac, NH4Cl, and tschermigite, (NH4)Al(SO4)2ź12H2O are the most common species on the BCD studied. Kremersite, (NH4,K)2[FeCl5(H2O)], is rare and coexists with members of the ammonioalunite–ammoniojarosite series. Boussingaultite, (NH4)2Mg(SO4)2ź6H2O, and more rarely clairite, (NH4)2Fe3(SO4)4(OH)3ź3H2O, and mascagnite, (NH4)2SO4, ac company numerous Mg, Al, Fe and Ca sulphate minerals. These usually occuras very fine admixtures forming coatings, small nodules or porous masses and were found on the BCD surface close to gas vents. Also a massive sulphate crust was found in the deeper part of the BCD nearby the fire zone. This crust is composed mainly of an hydrous sulphates: godovikovite, (NH4)(Al,Fe)(SO4)2 , and very minor sabieite, (NH4)Fe(SO4)2, and efremovite, (NH4)2Mg2(SO4)3, which were transformed into different hydrated sulphates in the outer zone of the crust. The fibrous or dendritic habit of many ammonium minerals, and the vesicular texture of some sulphate aggregates, point to their crystallization from the gas phase. Some ammonia miner ls may also have developed through hydration of prevlously formed phases or precipitated from locally formed aqueous solutions due to cooling or evaporation. The appear ance of ammonia minerals on BCD can be a useful indicator of the presence of underground fires.
Źródło:
Geological Quarterly; 2009, 53, 3; 341-356
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of the effects of bleomycin and ionizing radiation in two sublines of murine lymphoma L5178Y
Autorzy:
Kruszewski, M.
Zaim, J.
Grądzka, I.
Szumiel, I.
Powiązania:
https://bibliotekanauki.pl/articles/147561.pdf
Data publikacji:
2001
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
bleomycin
comet assay
DNA damage
gamma radiation
single cell gel electrophoresis
Opis:
We compared the effects of bleomycin (BLM) and ionizing radiation on two sublines of murine lymphoma L5178Y (LY): LY-R, radiation resistant and LY-S, radiation sensitive. This radiosensitivity difference is related to the ability to rejoin DNA double strand breaks. LY-S cells were about two times more sensitive to BLM than LY-R, similarly as in the case of sensitivity to X rays. Since there was no difference in the P-glycoprotein-related drug transport system between the sublines, it could be expected that the enhanced sensitivity of LY-S cells to BLM was caused by the DNA repair defect. Growth disturbances in BLM treated cell populations were proportional to the lethal effect and their duration was observed until elimination of dead cells (3-6 days after 50 ěM BLM, 1 h at 37oC). There was no slow growth phase accompanied by normal viability, as previously described for X-irradiated LY-S cells. Initial DNA damage, estimated with the single cell gel electrophoresis method was linearly related to BLM dose in LY-S cells; in LY-R cells - in the low dose range (up to 10 ěM) - there was more damage than in LY-S cells, however, at higher doses the dose - effect curves became identical. The doseeffect relationship for ă rays was linear and identical in both cell sublines. DNA damage distribution in BLM treated cells was much less uniform as compared to that in irradiated cells and indicated the presence of cells with severely damaged DNA, a feature typical for BLM action in vitro.
Źródło:
Nukleonika; 2001, 46, 3; 81-86
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Telematic security system for cash transport vehicle
Autorzy:
Kamiński, T.
Kruszewski, M.
Niezgoda, M.
Gacparska-Stołek, J.
Powiązania:
https://bibliotekanauki.pl/articles/245531.pdf
Data publikacji:
2011
Wydawca:
Instytut Techniczny Wojsk Lotniczych
Tematy:
transport
road transport
simulation
combustion engines
air pollution
environmental protection
Opis:
Paper describes security system mounted in the cash transport vehicle that was developed in "Pancermet" project. Consortium consists in addition to the Motor Transport Institute, another nine entities which represent science, vehicle producers and military. The system fulfils the new legal requirements in this area, and consists of the inside/outside video monitoring module and selective door locking mechanism. Every device was designed in accordance with safety and security principles. The video monitoring module includes four video cameras, audiovideo recorder and smoke detector. Selective door lock module cooperates with on-board CAN network that allows selective doors locking with usage of the dedicated touch panel installed on the vehicle's dashboard. The module continually monitors the CAN network which allows also to gain information about opening and closing of every door and status of the lock. Information at touch panel screen, is continuously refreshed, allowing keeping control over all doors, for driver and transporting manager. Article describes also general description about communication with door locks in CAN network and problems encountered during modules development and their solutions. In article there were presented used devices which allows preparing the system for cash transport vehicle.
Źródło:
Journal of KONES; 2011, 18, 3; 149-154
1231-4005
2354-0133
Pojawia się w:
Journal of KONES
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pierwsze wystąpienie botallackitu w Polsce (kopalnia Polkowice-Sieroszowice)
The first botallackite occurrence in Poland (Polkowice-Sieroszowice mine)
Autorzy:
Siuda, R.
Łodziński, M.
Syczewski, M.
Kruszewski, Ł.
Pršek, J.
Hoffmann, P.
Powiązania:
https://bibliotekanauki.pl/articles/2061780.pdf
Data publikacji:
2017
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
botallackit
paratacamit
klinoatacamit
kopalnia Polkowice-Sieroszowice
botallackite
paratacamite
clinoatacamite
Polkowice-Sieroszowice mine
Opis:
W wyrobiskach górniczych kopalni miedzi Polkowice-Sieroszowice stwierdzono występowanie botallackitu, stowarzyszonego z paratacamitem, klinoatacamitem, gipsem i halitem. Botallackit krystalizuje z bogatych w chlorki (3500 mg/dm3) wód kopalnianych o podwyższonej temperaturze (33°C). Na podstawie analiz składu chemicznego w mikroobszarze wyróżniono dwie odmiany botallackitu. Pierwsza z nich charakteryzuje się niewielką substytucją jonu Cu2+ przez Pb2+, Fe2+ oraz Zn2+. Średni wzór chemiczny tej odmiany obliczony na podstawie 50 analiz jest następujący: (Cu1,94Pb0,02Fe0,02Zn0,02) Σ = 2,00Cl0,98(OH)3,02. W drugiej odmianie botallackitu stwierdzono znaczą substytucję kationów Cu2+ przez jony Pb2+, Fe2+, Zn2+iMn2+. Średni wzór chemiczny tej odmiany, obliczony na podstawie 40 analiz w mikroobszarze jest następujący: (Cu1,85Pb0,09Fe0,04Zn0,02) Σ = 2,00Cl1,05(OH)2,95. Obliczone parametry komórki elementarnej (metodą Rietvelda) są następujące: a = 5,7165(2), b = 6,1362(2), c = 5,6325(2), β = 92,943(3). Botallackit jest najmniej trwałą polimorficzną odmianą substancji Cu2Cl(OH)3, która ostatecznie rekrystalizuje w znacznie bardziej stabilne polimorfy Cu2Cl(OH)3. Proces przemiany botallackitu może być spowalniany przez wysokie stężenie jonów Ca2+ w wodach kopalnianych. Również zastępowanie miedzi przez inne kationy dwuwartościowe może działać stabilizująco na strukturę tego minerału i zapobiegać jego dalszej transformacji. Wystąpienie botallackitu w kopalni Polkowice- Sieroszowice jest pierwszym udokumentowanym stanowiskiem tego minerału w Polsce.
The presence of botallackite was recognized in an underground galery in the Polkowice-Sieroszowice copper mine. This mineral coexists with paratacamite, clinoatacamite, gypsum and halite. Botallackite crystallized from chloride-reach (3500 mg/dm3), warm (33°C) mine water. On the basis of microprobe analyses, two types of botallackite were recognized. The first one contains only small amounts of Pb, Fe and Zn. These elements substitute Cu2+ ions in small proportions. Empirical formula of this botallackite is: (Cu1.94Pb0.02Fe0.02Zn0.02) Σ = 2.00Cl0.98(OH)3.02. The second type of the mineral were characterized by increased amounts of Pb, Fe, Zn. The empiric formula of this type of botallackite can be expressed as: (Cu1.85Pb0.09Fe0.04Zn0.02) Σ = 2.00Cl1.05(OH)2.95. The calculated unit-cell parameters of botallackite from Polkowice-Sieroszowice mine are as follows: a = 5.7165(2), b = 6.1362(2), c = 5.6325(2), β = 92.943(3). Botallackite is a least stable polymorph of Cu2Cl(OH)3 and finally transforms to more stable polymorphs. The botallackite recrystallization can be inhibit by high concentration of Ca2+ in the mine water. Substitution of Cu2+ ions by other divalent cations can slows the rapidity of recrystalization this mineral and prevent its further transformation also. The Polkowice-Sieroszowice mine is the first occurrence of botallackite in Poland.
Źródło:
Biuletyn Państwowego Instytutu Geologicznego; 2017, 469; 217--227
0867-6143
Pojawia się w:
Biuletyn Państwowego Instytutu Geologicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Matrix metalloproteinase 3 polymorphisms as a potential marker of enhanced susceptibility to lung cancer in chronic obstructive pulmonary disease subjects
Autorzy:
Brzoska, K.
Bartlomiejczyk, T.
Sochanowicz, B.
Cymerman, M.
Grudny, J.
Kolakowski, J.
Kapka-Skrzypczak, L.
Kruszewski, M.
Sliwinski, P.
Roszkowski-Sliz, K.
Powiązania:
https://bibliotekanauki.pl/articles/49715.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2014, 21, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treatment with silver nanoparticles delays repair of X-ray induced DNA damage in HepG2 cells
Autorzy:
Wojewódzka, M.
Lankoff, A.
Dusińska, M.
Brunborg, G.
Czerwińska, J.
Iwaneńko, T.
Stępkowski, T.
Szumiel, I.
Kruszewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/147061.pdf
Data publikacji:
2011
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
silver nanoparticles (Ag NP)
titanium dioxide nanoparticles (TiO2 NP)
DNA break rejoining
alkaline comet assay
ionizing radiation
combined treatment with nanoparticles + X-rays
Opis:
Nanoparticles (NPs) defined as particles having at least one dimension below 100 nm have been applied in the last decade in industry and medicine. Recently, there is an increased concern about the biohazard aspect of the presence of NP in consumer goods and in the environment. Silver NP (Ag NP) cause oxidative stress in mammalian cells in result of generation of reactive oxygen species (ROS). This results in genotoxicity and mutagenicity, disturbed mitochondrial respiration, slowed proliferation and cell death. Using the alkaline comet assay, we examined the effect of combined treatment with Ag NP 20 nm or 200 nm and X-rays (2 Gy) in HepG2 cells. In addition, combined treatment with X-rays and titanium dioxide NP (TiO2 NP) 21 nm was also studied. No effect of NP pre-treatment on X-ray induced initial deoxyribonucleic acid (DNA) damage levels was observed for all three NP. In contrast, Ag NP treatment preceding exposure to X-rays caused a marked decrease in the rate of single strand break rejoining. The effect was particularly strong for Ag NP 20 nm. TiO2 NP pre-treatment had no effect on DNA repair.
Źródło:
Nukleonika; 2011, 56, 1; 29-33
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 17

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