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    Wyświetlanie 1-14 z 14
    Tytuł:
    Predictive-SVM control method dedicated to an AC/DC converter with an LCL grid filter
    Autorzy:
    Dmitruk, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/200760.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    three-phase voltage converter
    model predictive control
    space vector modulation
    infinite control set
    Opis:
    This paper presents simulation and laboratory test results of an implementation of an infinite control set model predictive control into a three-phase AC/DC converter. The connection between the converter and electric grid is made through an LCL filter, which is characterized by a better reduction of grid current distortions and smaller (cheaper) components in comparison to an L-type filter. On the other hand, this type of filter can cause strong resonance at specific current harmonics, which is efficiently suppressed by the control strategy focusing on the strict control input filter capacitors voltage vector. The presented method links the benefits of using linear control methods based on a space vector modulator and the nonlinear ones, which result in excellent control performance in a steady state as well as in a transient state.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2020, 68, 5; 1049-1056
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Frequency based islanding detection methods in power electronic converters
    Autorzy:
    Dmitruk, K.
    Korzeniewski, M.
    Sikorski, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1193396.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    anti-islanding protection
    active frequency drift
    grid converter
    Opis:
    Frequency based methods developed to detect an islanding condition in modern power grid structures have been discussed. The condition may occur in power grid lines to which additional energy sources with power electronic converters have been connected such as solar panels or wind turbines. It is a hazardous operating state for grid workers and devices connected to the islanded part of the grid. Such a state results from the inability to control amplitude and frequency of basic harmonic of the grid voltage. An islanding problem in a power grid with additional small energy sources has been discussed. A basic passive and active islanding detection method have been presented and compared with known frequency based algorithms, namely active frequency drift and active frequency drift with a positive feedback algorithm. Finally, a laboratory test of the proposed islanding detection methods in a three-phase grid with an AC-DC converter has been conducted. To demonstrate differences between the tested methods, total harmonic distortion injected into the output converter current and detection time of islanding state have been measured.
    Źródło:
    Power Electronics and Drives; 2017, 2, 37/1; 27-41
    2451-0262
    2543-4292
    Pojawia się w:
    Power Electronics and Drives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Method for Filling and Sharpening False Colour Layers of Dual Energy X-ray Images
    Autorzy:
    Dmitruk, K.
    Mazur, M.
    Denkowski, M.
    Mikołajczak, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/227318.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    X-ray imaging
    image processing
    false colour
    object detection
    Opis:
    An X-ray scanning and image processing have a vast range of applications in the security. An image of a content of some package being passed for example to an airplane or to the court house may help to figure out if there are any dangerous objects inside that package and to avoid possible threatening situation. As the raw X-ray images are not always easy to analyze and interpret, some image processing methods like an object detection, a frequency resolution increase or a pseudocolouring are being used. In this paper, we propose a pseudocoloring improvement over material based approach. By addition of the edge detection methods we fill and sharpen colour layers over the image, making it easier to interpret. We demonstrate the effectiveness of the methods using real data, acquired from a professional dual energy X-ray scanner.
    Źródło:
    International Journal of Electronics and Telecommunications; 2016, 62, 1; 49-54
    2300-1933
    Pojawia się w:
    International Journal of Electronics and Telecommunications
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relacje inwestorskie jako narzędzie kształtowania reputacji spółek giełdowych
    Investor relations as a tool for shaping the reputation of listed companies
    Autorzy:
    Dmitruk, J.
    Krzyzanowska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/887935.pdf
    Data publikacji:
    2013
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Opis:
    Współczesny rynek finansowy nie mógłby spełniać swoich funkcji bez odpowiedniej komunikacji między podmiotami. Dwustronny proces komunikacji między spółkami giełdowymi a interesariuszami jest obszarem działania relacji inwestorskich (Investor Relations - IR). Podstawowe korzyści wynikające ze skutecznie prowadzonych relacji inwestorskich to redukcja kosztów pozyskania kapitału, wyższa płynność akcji i rzetelna wycena wartości spółki, zwiększenie poziomu zaufania i osiągnięcie pożądanej reputacji przedsiębiorstwa. W opracowaniu zaprezentowano teoretyczne zagadnienia związane z reputacją przedsiębiorstwa i relacjami inwestorskimi oraz wyniki badań własnych przeprowadzonych wśród dwóch opcji opiniotwórczych związanych z IR.
    Today's financial market could not fulfil its functions without adequate communication between operators. Two-way process of communication between listed companies and stakeholders is an area of investor relations (Investor Relations - IR). Key benefits of effective investor relations led to reduction in the cost of capital, higher liquidity and a reliable valuation of the company and increase the level of trust and achieve the desired reputation. The paper presents the theoretical issues related to the reputation of the company and investor relations, and the results of research conducted between two options multipliers associated with IR.
    Źródło:
    Zeszyty Naukowe Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie. Polityki Europejskie, Finanse i Marketing; 2013, 10[59]
    2081-3430
    Pojawia się w:
    Zeszyty Naukowe Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie. Polityki Europejskie, Finanse i Marketing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Manufacturing of Al Alloy Matrix Composite Materials Reinforced with MAX Phases
    Autorzy:
    Dmitruk, A.
    Naplocha, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/382950.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    MAX phase
    SHS synthesis
    microwave
    porous structure
    squeeze casting
    faza MAX
    synteza SHS
    mikrofala
    struktura porowata
    Opis:
    A method for manufacturing of Al-Si alloy (EN AC-44200) matrix composite materials reinforced with MAX type phases in Ti-Al-C systems was developed. The MAX phases were synthesized using the Self-propagating High-Temperature Synthesis (SHS) method in its microwave assisted mode to allow Ti2AlC and Ti3AlC2 to be created in the form of spatial structures with open porosity. Obtained structures were subjected to the squeeze casting infiltration in order to create a composite material. Microstructures of the produced materials were observed by the means of optical and SEM microscopies. The applied infiltration process allows forming of homogeneous materials with a negligible residual porosity. The obtained composite materials possess no visible defects or discontinuities in the structure, which could fundamentally deteriorate their performance and mechanical properties. The produced composites, together with the reference sample of a sole matrix material, were subjected to mechanical properties tests: nanohardness or hardness (HV) and instrumental modulus of longitudinal elasticity (EIT).
    Źródło:
    Archives of Foundry Engineering; 2018, 18, 2; 198-202
    1897-3310
    2299-2944
    Pojawia się w:
    Archives of Foundry Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analiza bezpieczeństwa Microsoft RMS
    Security analysis of Microsoft RMS
    Autorzy:
    Dmitruk, J.
    Kaczyński, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/209332.pdf
    Data publikacji:
    2017
    Wydawca:
    Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
    Tematy:
    DRM
    kryptografia
    kryptoanaliza
    RMS
    Microsoft
    cryptography
    cryptanalysis
    Opis:
    Microsoft Rights Management Services (RMS) to system mający zapewniać ochronę i prawidłowe użytkowanie dokumentów elektronicznych. RMS pozwala na stosowanie różnej polityki dostępu do dokumentu, pozwalając na kontrolę jego obiegu i wykorzystania. System umożliwia zdefiniowanie polityki dostępu nie tylko w momencie tworzenia danego dokumentu, lecz także po jego dystrybucji. Microsoft RMS wykorzystuje szereg zaawansowanych mechanizmów kryptograficznych mających zapewnić bezpieczeństwo usługi. W niniejszej pracy została przeprowadzona analiza bezpieczeństwa usługi RMS, wskazująca na istnienie szeregu luk w ochronie dokumentów. Zaproponowane zostały metody rozwiązania podstawowych problemów, w szczególności związanych z zapewnieniem integralności danych.
    Microsoft Rights Management Services (RMS) is a system designed to ensure the protection and proper use of electronic documents. RMS allows to apply different access policies for documents, thus allowing to control their use in time. The system allows not only defining access policies at document creation, but also after its distribution. Microsoft RMS uses a number of advanced cryptographic mechanisms and primitives to ensure overall service security. In this paper, we have analyzed the security of RMS, indicating a number of possible gaps. The methods of solving those problems, especially those related to data integrity, have been proposed.
    Źródło:
    Biuletyn Wojskowej Akademii Technicznej; 2017, 66, 4; 75-88
    1234-5865
    Pojawia się w:
    Biuletyn Wojskowej Akademii Technicznej
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A Comparative Study of the Feasibility of Cellular MAX Phase Preforms Formation by Microwave-Assisted SHS and SPS Techniques
    Autorzy:
    Dmitruk, A.
    Lagos, M.
    Naplocha, K.
    Egizabal, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/352206.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    MAX phases
    SHS synthesis
    microwave
    SPS
    porous preform
    Opis:
    Two methods were evaluated in terms of manufacturing of MAX phase preforms characterized with open porosity: microwave-assisted self-propagating high-temperature synthesis (SHS) and spark plasma sintering (SPS). The main purpose of fabrication of such open-porous preforms is that they can be successfully applied as a reinforcement in metal matrix composite (MMC) materials. In order to simulate the most similar conditions to microwave-assisted SHS, the sintering time of SPS was significantly reduced and the pressure was maintained at a minimum value. The chosen approach allows these two methods to be compared in terms of structure homogeneity, complete reactive charge conversion and energy effectivity. Study was performed in Ti-Al-C system, in which the samples were compacted from elemental powders of Ti, Al, C in molar ratio of 2:1:1. Manufactured materials after syntheses were subjected to SEM, XRD and STEM analyses in order to investigate their microstructures and chemical compositions. As was concluded, only microwave-assisted SHS synthesis allows the creation of MAX phases in the studied system. SPS technique led only to the formation of intermetallic secondary phases. The fabrication of MAX phases’ foams by microwave-assisted SHS presents some interesting advantages compared to conventional manufacturing methods. This work presents the characterization of foams obtained by microwave-assisted SHS comparing the results with materials produced by SPS. The analysis of SPS products for different sintering temperatures provided the better insight into the synthesis of MAX phases, supporting the established mechanism. Dissimilarities in the heating mechanisms that lead to the differing synthesis products were also discussed.
    Źródło:
    Archives of Metallurgy and Materials; 2020, 65, 2; 575-582
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design of Honeycomb Structures Produced by Investment Casting
    Autorzy:
    Naplocha, K.
    Dmitruk, A.
    Mayer, P.
    Kaczmar, J. W.
    Powiązania:
    https://bibliotekanauki.pl/articles/382969.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    investment casting
    3D printing
    honeycomb design
    light structure
    odlewnie
    drukowanie 3d
    projekt plaster miodu
    plaster miodu
    lekkie konstrukcje
    Opis:
    Investment casting combined with the additive manufacturing technology enables production of the thin-walled elements, that are geometrically complex, precise and can be easy commercialized. This paper presents design of aluminium alloy honeycombs, which are characterized with light structure, internal parallel oriented channels and suitable stiffness. Based on 3D printed pattern the mould was prepared from standard ceramic material subjected subsequently to appropriate heat treatment. Into created mould cavity with intricate and susceptible structure molten AC 44200 aluminium alloy was poured under low pressure. Properly designed gating system and selected process parameters enabled to limit the shrinkage voids, porosities and misruns. Compression examination performed in two directions showed different mechanisms of cell deformation. Characteristic plateau region of stress-strain curves allowed to determine absorbed energy per unit volume, which was 485 or 402 J/mm3 depending on load direction. Elaborated technology will be applied for the production of honeycomb based elements designated for energy absorption capability.
    Źródło:
    Archives of Foundry Engineering; 2019, 4; 76-80
    1897-3310
    2299-2944
    Pojawia się w:
    Archives of Foundry Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Changes in the pollen seasons of Acer spp. in Lublin, central-eastern Poland, in 2001–2015
    Zmiany w sezonach pyłkowych Acer spp. w Lublinie, Polska środkowo-wschodnia, w latach 2001-2015
    Autorzy:
    Weryszko-Chmielewska, E.
    Piotrowska-Weryszko, K.
    Haratym, W.
    Dmitruk, M.
    Sulborska, A.
    Vorobets, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/28357.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Botaniczne
    Opis:
    Many plant species respond to the climate change reported in the recent decades, which is confirmed by the results of phenological and aerobiological investigations. This paper presents characteristics of the pollen seasons of Acer spp. revealed by aerobiological analyses performed with the volumetric method in Lublin, Poland in 2001-2015. Additionally, phenological observations of flowering of four Acer species, i.e., A. negundo, A. platanoides, A. campestre, and A. pseudoplatanus, were carried out in 2011-2012. The results indicate a slight upward trend in the annual totals of Acer pollen grains. Over the last 10 years, the annual totals of Acer pollen grains have increased in comparison to the previous 5-year period. Acceleration of the onset of pollen seasons and the dates of peak days was noted. The comparison of the pollen seasons and flowering phenology of four Acer species indicates that A. negundo and A. platanoides produce the highest concentrations of pollen grains, whereas the pollen of A. campestre and A. pseudoplatanus accounts for a significantly lower proportion of the pollen content in the air of Lublin.
    Wiele gatunków roślin wykazuje reakcje na zmiany klimatyczne, które rejestrowane są w ostatnich dziesięcioleciach. Potwierdzają to wyniki badań fenologicznych i aerobiologicznych. W pracy przedstawiliśmy charakterystykę sezonów pyłkowych Acer ssp. na podstawie badań aerobiologicznych, przeprowadzonych metodą wolumetryczną w Lublinie w latach 2001-2015. Ponadto wykonaliśmy obserwacje fenologiczne, dotyczące kwitnienia w latach 2011-2012 czterech gatunków Acer: A. negundo, A. platanoides, A. campestre i A. pseudoplatanus. Wyniki badań wskazują na występowanie niewielkiego trendu wzrostowego, dotyczącego sum rocznych ziaren pyłku Acer. Sumy te w ciągu ostatnich 10 lat badań wzrosły o 32% w porównaniu z wcześniejszym pięcioleciem. Zaznaczyło się również przyśpieszenie początku sezonów pyłkowych oraz dat występowania maksymalnych koncentracji ziaren pyłku. Z porównania sezonów pyłkowych i danych dotyczących fenologii kwitnienia 4 gatunków Acer wynika, że najwyższe koncentracje ziaren pyłku przypadają na okres kwitnienia A. negundo i A. platanoides, zaś pyłek A. campestre i A. pseudoplatanus mają znaczenie mniejszy udział w zawartości pyłku rodzaju Acer w powietrzu Lublina.
    Źródło:
    Acta Agrobotanica; 2016, 69, 2
    0065-0951
    2300-357X
    Pojawia się w:
    Acta Agrobotanica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report
    Autorzy:
    Paszko-Patej, G.
    Sienkiewicz, D.
    Kułak, W.
    Okurowska-Zawada, B.
    Wojtkowski, J.
    Kalinowska, A.
    Okulczyk, K.
    Sochoń, K.
    Dmitruk, E.
    Mirska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918408.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Osteogenesis imperfecta
    granulocyte colony-stimulating factor
    muscle strength
    Opis:
    Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.
    Źródło:
    Progress in Health Sciences; 2017, 7(1); 205-208
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanohills in SiGe/Si structure formed by laser radiation
    Autorzy:
    Medvid', A.
    Onufrijev, P.
    Lyutovich, K.
    Oehme, M.
    Kasper, E.
    Dmitruk, I.
    Pundyk, I.
    Manak, I.
    Grabovskis, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/384291.pdf
    Data publikacji:
    2009
    Wydawca:
    Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
    Tematy:
    nanohills
    SiGe
    laser
    hetero-epitaxial structure
    Opis:
    Formation of self-assembling nanohills induced by irradiation of nanosecond Nd:YAG laser pulses on the Si0.7Ge0.3/Si hetero-epitaxial structures is reported. The atomic force microscope study of the irradiated surface morphology has shown a start of nanohills formation after laser irradiation of the intensity I=7.0 MW/cm2. The giant "blue shift" of photoluminescence spectra with maximum intensity in region of 700-800 nm (1.76 - 1.54 eV) is explained by the Quantum confinement effect in the nanohills. The maximum of this photoluminescence band slightly shifts to shorter wavelengths with the increase of the intensity of laser pulses used for sample treatment. Appearance of the 300 cm-1 Ge-Ge vibration band in Raman scattering spectra for sample irradiated with I=20.0MW/cm2 is explained by Ge phase formation. Formation of the Ge-rich phase is explained by localization of Ge atoms drifting toward the irradiated surface under the thermal gradient due to strong absorption of laser radiation.
    Źródło:
    Journal of Automation Mobile Robotics and Intelligent Systems; 2009, 3, 4; 62-64
    1897-8649
    2080-2145
    Pojawia się w:
    Journal of Automation Mobile Robotics and Intelligent Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Quality of life of children suffering from motor disabilities as evaluated by their parents
    Autorzy:
    Wojtkowski, J.
    Sienkiewicz, D.
    Okurowska-Zawada, B.
    Paszko-Patej, G.
    Konopka, A.
    Okulczyk, K.
    Średzińska, K.
    Dmitruk, E.
    Mirska, A.
    Kułak, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918580.pdf
    Data publikacji:
    2018-01-09
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Quality of life
    motor disability
    children
    parents
    Opis:
    Purpose: We assessed the quality of life of children with motor disabilities in comparison with healthy children, as evaluated by their parents, using the CHQ-PF28 questionnaire (Child Health Questionnaire—Parent Form). Materials and methods: In a prospective study, we evaluated the quality of life of 105 children with motor disabilities. Results: Our research showed lower quality of life in the group of children with motor disabilities compared with controls, both in terms of physical and psychosocial health. Significant correlations between independent walking and physical functioning, general behavior, and mental health of children suffering from motor disabilities were found. According to the average indices of quality of life of children suffering from motor disabilities, depending on sex, the greatest differences occurred in behavior and change of health status, while the smallest differences in self-esteem and parental involvement, compared with controls. In the case of healthy children, the largest differences appeared in the perception of pain, behavior, and self-esteem; whereas, the smallest variations occurred in the change of health status and physical activity. Conclusion: Children suffering from motor disabilities demonstrate lower quality of life compared with healthy children.
    Źródło:
    Progress in Health Sciences; 2017, 7(2); 60-66
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of short moderate exercise on hematological parameters and stem cells in healthy humans
    Autorzy:
    Sochoń, K.
    Sienkiewicz, D.
    Okurowska-Zawada, B.
    Paszko-Patej, G.
    Wojtkowski, J.
    Dmitruk, E.
    Żak, J
    Kułak, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918279.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Exercise
    healthy subjects
    stem cells
    Opis:
    Introduction: Exercise at various durations and intensities impact on blood and stem cells. This pilot study examined the effects of 30 minutes of treadmill walking on hematological indices and progenitor stem cells CD34+ in healthy subjects. Materials and methods: A total of 17 non-smoking, healthy students, aged 20 to 22 years participated. Hemoglobin, hematocrit, white blood cells, platelets, and stem cell CD34+ numbers were assessed before and after moderate exercise. Statistical analyses examined the relationships between CD34+ cells versus hematological indices, age, and body mass index. Results: Following exercise, significant increases were observed in leukocytes, neutrophils, eosinophils, and CD34+ cells numbers. For CD34+ cells, a fourfold increase was seen. Significant correlations between CD34+ cells, white blood cells, and neutrophils were found. Conclusion: Our results suggest that moderate exercise has a physiological impact on hematologic parameters and stem cells CD34+ in healthy subjects. Furthermore, our findings suggest that brief treadmill exercise may enhance tissue repair mechanisms so important in physiotherapy.
    Źródło:
    Progress in Health Sciences; 2016, 6(2); 184-187
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Granulocyte colony-stimulating factor therapy for facioscapulohumeral dystrophy: a case report
    Autorzy:
    Sienkiewicz, D.
    Kułak, W.
    Okurowska-Zawada, B.
    Paszko-Patej, G.
    Wojtkowski, J.
    Dmitruk, E.
    Okulczyk, K.
    Sochoń, K.
    Kalinowska, A.
    Żak, J.
    Pogorzelski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918329.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Facioscapulohumeral dystrophy
    granulocyte colony-stimulating factor
    muscle strength
    Opis:
    We examined the safety and effectiveness of a low dose of analog granulocyte-colony stimulating factor in a 15-year-old boy with facioscapulohumeral dystrophy. The onset of disease was noted at 12 years of age. The physical examination noted general muscle atrophy more pronounced at left side of the body. He was able to walk 300 meters within 6 minute walk test. Granulocyte colony-stimulating factor 5 μg/kg was given subcutaneously daily for 5 days/month for 1, 2, 3, 6 and 12 months. Clinical examination, laboratory tests including blood, biochemical tests, and CD34+ cells were performed. A significant increase of muscle strength in the lower and upper limbs between baseline, and after 3 months of treatment, after 6, and after 12 months was found. He was able to walk 480 meters within 6 minutes after 12 months. Electromyography demonstrated increase of amplitude in the examined in upper and lower limbs after six months compared to baseline. Leukocyte levels remained below 25000/μL. CD34+ increased significantly at day 5 of granulocyte colony-stimulating factor admini-stration. It was safe and well tolerated by the patient. A significant increase in muscle strength in this patient with facioscapulohumeral dystrophy after 3 months of treatment, after 6, and after 12 months since the first treatment course was completed may indicate beneficial effects of granulocyte colony-stimulating factor in this disorder.
    Źródło:
    Progress in Health Sciences; 2016, 6(2); 175-177
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-14 z 14

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