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Wyświetlanie 1-6 z 6
Tytuł:
La réécriture des modèles français et américains dans Cadavres de François Barcelo
Autorzy:
Sawicka, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/700755.pdf
Data publikacji:
2007
Wydawca:
Wydawnictwo Uniwersytetu Śląskiego
Opis:
The article presents François Barcelo’s roman noir “Cadavres” as an attempt at deconstructing the conventions of the literary genre. The definition of a “roman noir” is twofold. On one hand it is a gritty novel narrated by the perpetrator, on the other it delineates the dark side of the society. Barcelo’s novel transgresses the traditional model of the genre by the implementation of metafiction and elements of grotesque. Barcelo creates an original Quebecois crime novel by combining these two characteristics. In order to show the maladjustment and alienation of a social group, he creates an inept villain and transforms the setting of the novel, grotesquely turning an edgy metropolis into a boring provincial town. Thus “Cadavres” goes far beyond the existing French and American models of the black novel. Key words: François Barcelo; roman noir; metafiction; break with conventions
Źródło:
Romanica Silesiana; 2007, 2
1898-2433
2353-9887
Pojawia się w:
Romanica Silesiana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rozwój potraumatyczny u pacjentów z doświadczeniem psychozy podlegających detencji
Posttraumatic growth in detained patients with psychosis
Autorzy:
Wierzbicka, Sylwia
Malewicz-Sawicka, Maryla
Powiązania:
https://bibliotekanauki.pl/articles/1366333.pdf
Data publikacji:
2020-12-29
Wydawca:
Fundacja Pedagogium
Tematy:
schizofrenia
detencja
wzrost potraumatyczny
rehabilitacja psychospołeczna
schizophrenia
detention
posttraumatic growth
psychosocial rehabilitation
Opis:
Praca dotyczy czynników osobowościowych i sytuacyjnych związanych ze wzrostem potraumatycznym u osób chorujących na schizofrenię, które doświadczyły różnego rodzajusytuacji traumatycznych. Grupą badaną były osoby, które popełniły czyn zabroniony i przebywały na detencji (N = 30), a grupą kontrolną pacjenci hospitalizowani w oddziale dziennymrehabilitacji psychiatrycznej (N = 30). Do pomiaru zmiennych użyto: Inwentarza Osobowości NEO-FFI, Inwentarza Potraumatycznego Rozwoju, Kwestionariusza zmiennych społeczno-demograficznych oraz skali BPRS. Grupa badana uzyskała średnio wyższe wyniki w poziomie wzrostu potraumatycznego niż grupa kontrolna. W grupie kontrolnej osoby uzyskały wyższe wyniki w poziomie neurotyczności, z kolei osoby z grupy badanej w poziomie ekstrawersji. Najczęściej wskazywanym wydarzeniem traumatycznym w obu grupach było doświadczenieprzewlekłej choroby.
The study concerns the relationship of personality and situational factors with posttraumatic growth in people suffering from schizophrenia who have experienced varioustypes of traumatic events. The study group included people who committed an offense and were detained (N = 30), and the control group – patients hospitalized in the Daily Ward ofPsychiatric Rehabilitation (N = 30). The following tools were used to measure the examined variables: NEO Five-Factor Inventory, Posttraumatic Growth Inventory, sociodemographic variables questionnaire and Brief Psychiatric Rating Scale. The study group presented higher results in posttraumatic growth than the control group. Results indicated that patients fromthe control group attained higher results in Neuroticism, however patients from the study group – in Extraversion. In both groups the most frequently indicated traumatic event waschronic disease.
Źródło:
Resocjalizacja Polska; 2020, 20; 319-334
2081-3767
2392-2656
Pojawia się w:
Resocjalizacja Polska
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of dietary nitrates and acrylamide intake on systemic redox status in healthy young adults
Autorzy:
Piwowar, Agnieszka
Żurawska-Płaksej, Ewa
Bizoń, Anna
Sawicka, Ewa
Płaczkowska, Sylwia
Prescha, Anna
Powiązania:
https://bibliotekanauki.pl/articles/23370829.pdf
Data publikacji:
2023-12-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
acrylamide
nitrates
oxidative stress
intake with food
nutritional survey
oxidative/antioxidative balance
Opis:
Objectives The nitrogen-containing xenobiotics, such as nitrates and acrylamide may potentially influence systemic redox status and contribute to the generation of oxidative stress (OS) in the human body, but there is still a lack of studies that would evaluate the various parameters assessing the oxidative-antioxidant balance. The aim of this study was to evaluate the exposure to nitrates and acrylamide derived from daily diet and to analyze the impact of these nitrate-containing xenobiotics on the parameters of systemic redox status in healthy young adults. Material and Methods To assess nitrate and acrylamide intake in the study population, a semi-quantitative food frequency questionnaire was used. Systemic redox status was evaluated by measurement of a panel of biochemical parameters: enzymatic (glutathione S-transferase, glutathione reductase, glutathione peroxidase [GPx]) and non-enzymatic (uric acid, bilirubin and albumin), thiol/disulphide homeostasis parameters (total thiol, native thiol, and disulfide) and oxidative/ antioxidant balance indicators (total antioxidant status, total oxidant status, OS index). Results The average consumption of nitrates and acrylamide in the study population was 1.24 mg/kg b.w./day and 0.23 μg/kg b.w./day, respectively, which is within the normal value range. Of 12 measured parameters, significant differences were revealed for disulfide and total thiol levels, which were increased in the subgroup with the highest daily intake of nitrates compared to the subgroup with the lowest intake; for GPx, which was highest in the subgroup of the lowest daily intake of acrylamide; and for native thiols in the subgroup with the highest daily intake. Conclusions The intake of nitrogen-containing xenobiotics within the range considered as normal does not markedly influence redox state parameters in healthy young adults. Some significant changes were revealed only for thiol/disulphide homeostasis parameters, which may be the first line of antioxidant defense, as well as for GPx activity. Compensative mechanisms in healthy young people are efficient enough to neutralize OS induced by slightly increased exposure to nitrogen-containing xenobiotics delivered with food.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 773-787
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells
Autorzy:
Horwacik, Irena
Durbas, Małgorzata
Boratyn, Elżbieta
Sawicka, Anna
Węgrzyn, Paulina
Krzanik, Sylwia
Górka, Anna
Drożniak, Joanna
Augustyniak, Ewa
Kowalczyk, Aleksandra
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1038977.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
doxorubicin
GD2 ganglioside
microarray
14G2a
neuroblastoma
mimitin
Opis:
Neuroblastoma is the most common extra-cranial solid tumor of childhood and it is characterized by the presence of a glycosphingolipid, GD2 ganglioside. Monoclonal antibodies targeting the antigen are currently tested in clinical trials. Additionally, several research groups reported results revealing that ganglioside-specific antibodies can affect cellular signaling and cause direct cytotoxicity against tumor cells. To shed more light on gene expression signatures of tumor cells, we used microarrays to analyze changes of transcriptome in IMR-32 human neuroblastoma cell cultures treated with doxorubicin (DOX) or a mouse monoclonal antibody binding to GD2 ganglioside 14G2a (mAb) for 24 h. The obtained results highlight that disparate cellular pathways are regulated by doxorubicin and 14G2a. Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1. Then, we applied western blot and analyzed levels of RPS27L, PPM1D, sestrin 1 proteins after DOX-treatment. Additionally, we aimed to measure effects of doxorubicin and topotecan (TPT) and 14G2a on expression of a novel human NDUFAF2 gene encoding for mimitin protein (MYC-induced mitochondrial protein) and correlate it with expression of the MYCN gene. We showed that expression of both genes was concomitantly decreased in the 14G2a-treated IMR-32 cells after 24 h and 48 h. Our results extend knowledge on gene expression profiles after application of DOX and 14G2a in our model and reveal promising candidates for further research aimed at finding novel anti-neuroblastoma targets.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 423-433
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aminokwasy, glikany, peptydy i białka w ścieżkach diagnostycznych i terapeutycznych chorób cywilizacyjnych XXI wieku : projektowanie i charakterystyka fizykochemiczna oraz strukturalna
Amino acids, glycans, peptides and proteins in the diagnostic and therapeutic pathways of the 21st century civilization diseases : design, physicochemical and structural characterisation
Autorzy:
Bylińska, Irena
Dzierżyńska, Maria
Giżyńska, Małgorzata
Guzow, Katarzyna
Jankowska, Elżbieta
Jurczak, Przemysław
Kaczyński, Zbigniew
Karska, Natalia
Kowalczyk, Agnieszka
Kuncewicz, Katarzyna
Orlikowska, Marta
Sawicka, Justyna
Spodzieja, Marta
Szpakowska, Nikola
Szymańska, Aneta
Wieczerzak, Ewa
Witkowska, Julia
Rodziewicz-Motowidło, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/2200549.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
fluorophores
fluorescence spectroscopy
antimicrobial activity
anticancer activity
Cystapep
Stahylococcus aureus
antimicrobial compounds
amyloidogenic protein
mutagenesis
fibrilization
proteasome
aging
neurodegeneration
self-assembling peptides
tissue engineering
biomaterials
immune checkpoints
peptide inhibitors
immunotherapy
ligands of TAP protein
viral diseases
NMR structure of the UL49.5 protein
glycans
glycoconjugates
fluorofory
spektroskopia fluorescencyjna
aktywność przeciwdrobnoustrojowa
aktywność antynowotworowa
Staphylococcus aureus
związki przeciwbakteryjne
białko amyloidogenne
mutageneza
fibrylizacja
proteasom
procesy starzeniowe
neurodegeneracja
peptydy samoorganizujące
inżynieria tkankowa
biomateriały
punkty kontrolne układu immunologicznego
inhibitory peptydowe
immunoterapia
ligandy białka TAP
choroby wirusowe,
struktura NMR białka UL49.5
glikany
glikokoniugaty
Opis:
The civilization diseases of the 21st century are non-infectious disorders, affecting a large part of modern society. They are associated with the significant development of industry and technology, and hence with environmental pollution and an unhealthy lifestyle. These factors have led to the development of many civilization diseases, which currently include: cardiovascular diseases, respiratory diseases, diabetes, obesity, malignant tumors, gastrointestinal diseases, mental disorders and allergic diseases. The development of technologies, including modern therapies and new drugs, resulted in increase in life expectancy. This creates a global problem of an aging population with an increasing number of diseases of the old age, i.e. dementias. In addition, sedentary lifestyles and changing diets are the reasons why more and more people develop metabolic diseases, as well as neurological and cognitive disorders characterized by progressive damage to nerve cells and dementia. Currently, problem on a global scale is also the growing resistance to existing antimicrobial drugs. Therefore, the scientists face many challenges related to searching for the causes of these diseases, their diagnosis and treatment. Scientific research conducted at the Department of Biomedical Chemistry at the Faculty of Chemistry of the University of Gdańsk is part of this research trend. In this publication, we discuss various research topics with the long-term aim of solving the problems associated with the diseases mentioned above. The following chapters are dedicated to (i) looking for new effective fluorophores with diagnostic and anti-cancer activity; (ii) designing of new compounds with antibacterial and antiviral activity and their synthesis; (iii) investigating the mechanisms of amyloid deposit formation by human cystatin C and possibilities of inhibition of this process; (iv) designing and studies of compounds activating the proteasome with the potential to suppress the development of neurodegenerative diseases; (v) designing peptide fibrils and hydrogels as drug carriers; (vi) searching for peptide inhibitors of immune checkpoint as potential drugs for immunotherapy; (vii) studying the mechanism of action of selected herpesviruses by determining the structure of viral proteins and (viii) studying the composition of natural glycans and glycoconjugates in order to better understand the mechanisms of interaction of bacteria with the environment or with the host.
Źródło:
Wiadomości Chemiczne; 2022, 76, 5-6; 393--431
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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