Niektore parametry odpornosci u pacjentow z rzesistkowica jamy ustnej powiklanej grzybica [trichomonosomycosis]

The objective of the study was the analysis of selected parameters of humoral and cellular immunity in patients with Trichomonas tenax and fungi existing concurrently in the oral cavity ontocenosis. The study included 37 patients (age range 26-70 years, x=54.5±4.l) diagnosed with trichomonosomycosis. Standard methods were used to determine the total level of protein and its individual fractions, leukocytosis and sedimentation rate. Serum levels of immunoglobulins IgA, IgM and IgG, and the level of IgA immunoglobulin in saliva (S-IgA) were determined with the immunodilTussion method using NOR-Partigen and LC-Partigen (Behring) platelets. To define blastic and miotic indices (IB and IM), rosette tests ER, EAR and EACR as well as phytohemagglutinin-induced (PHA) blastic transformation test were employed. In 21.1% of patients, a decrease in total protein level (on the average 6.85±0.23 g/dl), and in 11.1% in globulins of y fraction (18.5±1.18%) was observed, in 40% of cases the leukocytes count was higher (10080±690.7), and in all patients the sedimentation rate was accelerated (77.9±12.2 mm). The level of class A immunoglobulins (368.7±49,0 mg%) was in 29.2% above norm, and of IgG class (1182.8±92.9 mg%) was in 13.6% below norm and in 13.6% above norm. In case of S-IgA (8.15±0.63 mg%), the level was below norm in all patients. Also in all patients a decreased lymphocytes T count (value ER - 37.3±1.04%) and deficiency in their function (indices: IB 22.5±2.98%, IM 2.3±0.84%) could be observed, whereas lymphocytes B count was increased (values EAR - 18.3±0.7%; values EACR -22.1-0.77). These data indicate that in cases of oral trichmonosomycosis there occurs a low level of secretory immunoglobulin class A in saliva and the number of lymphocytes T, deficient in function, is decreased.