Próba oceny penetracji środków rzęsistkobójczych w układzie rodnym kobiety w oparciu o badania diagnostyczne

The author studied the distribution of T. vaginalis in the reproductive tract of woman. The preliminary results indicate that the parasite may be confined to some segments of the system mostly to the paraurethral glands or to the urethra without invading the vagina, even for several weeks' time. Further observations are concerned with the behaviour of T. vaginalis in particular segments of the tract both prior and after oral and intravaginal treatment with the following drugs: Flagyl, Aminitrozol, Devaginol and the recent Polish preparation Chelivag. The observations were made in 50 women, the results being evaluated by culture method. The preliminary evaluation of the results obtained suggest that the estimation of the drugs in question should involve topographic examinations (urethra, paraurethral glands, vagina and the canal of the uterine cervix), since the drugs often proved to be effective in the vagina, while they failed to act in the paraurethral glands and the urethra. This finding is likely to be the result of uneven penetration of the drug used into all segments of the uro-genital tract in women. This might account for unexplained recurrences of T. vaginalis in the vagina as late as after second or third follow-up examination. The existence of drug-resistant strains in particular segments of the uro-genital system is open to discussion.