Phytosulfokine-α (PSK-α) (H-Tyr(SO3H)-Ile-Tyr(SO3H)-Thr-Gln-
OH) (I), a sulfated growth factor universally found in both monocotyledons
and dicotyledons, strongly promotes proliferation of plant cells in culture. The
C-terminal truncated analog named PSK-β (Tyr(SO3H)-Ile-Tyr(SO3H)-Thr) (II)
showed a 10-fold lower activity than that of the parent pentapeptide. Because
PSK-α promotes proliferation and differentiation during the plant growth we
undertook the studies on the influence of PSK-α on plant defense mechanisms
in that period. In present studies on PSK-α (I), PSK-β (II), and its analogues, we
performed a search of another biological properties.
The aim of our investigation was evaluation of PSK-α, PSK-β and their selected
analogues in relation to growth and development of plant pathogens, such as
Phoma narcissi and Botrytis tulipae. In these studies we elaborated the synthesis
of PSK-α or PSK-β and their 22 analogues modified by natural and non-natural
amino acid residues.
Peptides were synthesized by the solid phase method according to the Fmoc
procedure on a Wang-resin. Free peptides were released from the resin by 95%
TFA in the presence of EDT.
Biological effect of these peptides was evaluated by test on the growth and
development of pathogens of P. narcissi and B. tulipae.
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