Ionic liquids (IL) are new materials with a wide spectrum of use. Being a variable combination
of an organic cation and an organic or inorganic anion, their have controllable
properties. The effect of the ionic liquid added to the mobile phase on the separation of
uracil derivatives is studied and demonstrated in this paper. The ionic liquid used was
didecyldimethylammonium lactate, which has an advantageous effect on the separation
of the analytes studied. Pyrimidine bases which were used as the test compounds are
characterized by alkaline properties due to which so-called peak tailing is observed
during separation. A methanol/water mixture was used as the mobile phase in the chromatographic
analyses. Optimum separations were obtained for 8% levels of the organic
modifier. The best separations of the test isomers were obtained for 0.01% IL added to
the mobile phase. The findings obtained are evidence that the use of ionic liquids in
HPLC is an efficient method for the separation of polar compounds: the duration of the
analysis is shorter and the resulting peaks are sharp and symmetrical.
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