Models of computational intelligence in bioinformatics

Computational Intelligence has emerged as a synergistic environment of Granular Computing (including fuzzy sets, rough sets, interval analysis), neural networks and evolutionary optimisation. This symbiotic framework addresses the needs of system modelling with regard to its transparency, accuracy and user friendliness. This becomes of paramount interest in various modelling in bioinformatics especially when we are concerned with decision-making processes. The objective of this study is to elaborate on the two essential features of CI that is Granular Computing and the resulting aspects of logic-oriented processing and its transparency. As the name stipulates, Granular Computing is concerned with processing carried out at a level of coherent conceptual entities - information granules. Such granules are viewed as inherently conceptual entities formed at some level of abstraction whose processing is rooted in the language of logic (especially, many valued or fuzzy logic). The logic facet of processing is cast in the realm of fuzzy logic and fuzzy sets that construct a consistent processing background necessary for operating on information granules. Several main categories of logic processing units (logic neurons) are discussed that support aggregative (and-like and or-like operators) and referential logic mechanisms (dominance, inclusion, and matching). We show how the logic neurons contribute to high functional transparency of granular processing, help capture prior domain knowledge and give rise to a diversity of the resulting models.