Koronawirusowy zespół ostrej biegunki świń

Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus in China, is associated with swine acute diarrhea syndrome (SADS), which has caused significant economic losses to the porcine industry. SADS-CoV has a very broad species tropism in vitro and can infect cell lines from 24 different animal species. Moreover, virus transmission, replication and in vitro gene expression is possible in on human cells of the liver, gut, and airway origin. Interestingly, none of the known human coronavirus receptors functions as a receptor for SADS-CoV. Also, SADS-CoV infection has not induced IFN‑β. Bats are considered to play an important role in epidemiology of swine disease. It is possible, that as bats prey on insects near pig facilities, their feces containing bat-HKU2-like porcine CoVs, contaminate swine feed, which is then eaten by pigs and rodents, that subsequently become carriers of SADS-CoV. The zoonotic transmission of novel coronaviruses into humans presents severe threats to the global health.