Mechanizmy inwazjii i wędrówki pasożytów w organiźmie żywiciela

The purpose of the summing up of the investigation results obtained heretofore and concerning the role of proteolytic enzymes in the invasiveness of parasites is to put a special stress upon this very interesting phenomenon in the system parasite-host. The discussion in this matter was limited to protozoa, and parasite worms and concerned mainly species which have been more often tested, viz. Entamoeba histolytica or Schistosoma cercariae. As regards the protozoa the incidence of casease, gelatinase and hyaluronidase has been talked over in the first line, whereas in the class of worms special attention was concentrated on activity of collagenase, lipase and hyaluronidase. The author refers also to own, unpublished up to now, results of investigations on the spreading factor activity in E. histolytica, E. moshkovskii, Trichomonas vaginalis, Toxoplasma gondii, Balantidium coli and Trichinella spiralis (muscular larvae and mature intestinal parasites). By means of turbidimetric methods and mucin clot prevention according to Mc Cleane (1943) he stated an incontestable activity, such as hialuronidase, to tell the truth - only in B. coli. The results of tests with other parasites were either negative or contradictory. Discussing own results and those obtained by other investigators the author points to the imperfection of methods applied to day and to the usage of insufficiently purified or altogether indeterminated substrats. Though we are still in the first stage of investigations on enzymatic phenomena in parasites, we can already see how valuable are such works which will, most certainly, cast light on some obscure problems of invasion and pathogenesis of invasive diseases.