Wrażliwość Entamoeba moshkovskii Tshalaia na nowe N-chlorowcoamidy kwasu benzenosulfonowego i związki analogiczne

Entamoeba moshkowskii was examined for the sensitivity to 14 salts of N-halogenamides of azobenzene sulphonic (I), p-chlorbenzenesulphonic (II), p-azobenzenesulphonic (III) and p-azobenzenedisulphonnic (IV) acids. The lethal doses of the compounds for 50% of Entamoeba were compared, after 10 minutes, with LD₅₀ of phenol. All halogenamides under examination were found to exert a stronger action than that of phenol. The lethal dosis of phenol for 50% of individuals was about 4-218 times higher than the doses of N-halogenamides. Among the salts of N-halogenamides of various acids the greatest killing effect on Entamoeba was exerted by the derivatives of p-azobenzenesulphonic, and the weakest by p-azobenzenedisulphonic acid. In the previous some of these compounds were found to possess treponemacidal and mycostatic properties.